Systems and methods for disabling Blow-Fill-Seal (BFS) vials such as pre-filled vials containing a vaccine or other medicament via utilization of an assistive dispensing device to selectively compress the fluid reservoir of the BFS vial. The assistive dispensing device can aid in applying compressive force to assist in dispensing the liquid from the vial, and may also be utilized to lock in a mated position so that the BFS vial may not be reused and/or is otherwise readily identifiable as having already been administered.

A cartridge droplet dosage device with a cartridge (1) and an actuation element (2), whereby the cartridge (1) includes a reservoir body (3), a cladding (5) and a plug (6), characterized in that a fluid groove (9) projects from the reservoir body (3) into an inner tube valve area (11), whereby the fluid groove (9) is releasable either by the yielding of a sealing rib (12) and/or by the yielding of a part of the cladding (5).

A device for mixing and dispensing bone material is provided. The device comprises a tubular member having an interior surface configured to receive bone material and a fluid to mix the bone material disposed within the tubular member. The tubular member is flexible and has a proximal opening configured to slidably receive a plunger, and a distal opening configured to dispense a mixed bone material from the interior surface of the tubular member. The plunger is less flexible than the tubular member. Methods of mixing and dispensing bone material are also provided.

A fluid delivery injector comprises a syringe defining a barrel; a plunger and a hollow needle provided within the barrel adapted for linear movement parallel to a longitudinal axis with a distal tip of the needle contained within the syringe. A fluid retention reservoir is defined at least in the barrel and is in fluid communication with the needle when pressure is applied to the fluid in the reservoir and to the plunger for moving the needle out of the barrel. A spring may be provided for retracting the needle when pressure is released from the plunger.

A medicant injection device includes a compressible body, a tip, and an outer luer body. The compressible body has a proximal end, a distal end, and a plurality of bellows, and defines an inner cavity for holding a liquid medicant. The tip is positioned at the proximal end of the compressible body. The outer luer body includes internal threads, and is positioned over and engaged with the tip to form a first fitting therewith. The first fitting is configured to be connected with a second fitting. A medicant injection device includes a compressible body having first and second arms, a receptacle interconnected with the compressible body and defining an inner cavity, and a first fitting configured to engage a second fitting. The compressible body is configured to be compressed by forcing the distal end of the first and second arm toward each other.

An auto-injector operable in a single activation step. The auto-injector is automatically armed when removed from its carrying receptacle. The auto-injector may be prefilled with more than one constituent of a beneficial agent, stored in separated compartments, in such an arrangement that the compartments will automatically merge when the auto-injector is removed from its carrying receptacle.

A medicament delivery device for delivering a dose of medicament into an injection site comprises an expandable reservoir (130) for receiving the medicament, a holder (102) for receiving the reservoir (130), attachment means (104, 110) for securing the holder (102) to the injection site, a cannula (174) moveable from a stowed position in which the cannula (174) does not project from the device (100) to a deployed position in which the cannula (174) provides fluid connection between the reservoir (130) and the injection site, and an elastic element (106). In use, the elastic element (106) is held under strain by the medicament in the reservoir (130) and delivery of the medicament through the cannula (174) is driven by relaxation of the elastic element (106) when the cannula (174) is in the deployed position. The device is preferably in the form of an arm band or a patch.

A delivery device includes a base body having an outlet opening and a chamber for receiving a flowable substance to be administered. The base body, having first and second film portions attached to each other by a connection with a plurality of regions, being configured to discharge the substance through the outlet opening by compressing the chamber. The delivery device further includes a pouring adapter tightly connected to the outlet opening. The plurality of regions of the connection include a more resilient region and a less resilient region that are arranged between the chamber and the outlet opening. When the chamber is compressed to discharge the substance through the outlet opening, the less resilient region is configured to come undone and the more resilient region is configured to remain connected so that the substance can be discharged solely through the outlet opening and the pouring adapter by compressing the chamber.

A device for mixing and delivering a solution includes a tubular barrel that includes a first end, a second end, and interior compartment. A first plunger is positionable at the first end of the barrel, is moveable within the interior compartment of the barrel, and includes a spike protruding into the interior compartment, the spike having an end configured for piercing a membrane. A second plunger is positionable within the barrel, is also moveable within the interior compartment of the barrel, and has a pierceable membrane. The second plunger and the second end form a first area within the barrel for housing a first solution to be mixed and the first and second plungers form a second area within the barrel for housing a second solution to be mixed. The first and second plungers are slidably arranged within the interior area of the tubular barrel such that moving the first plunger toward the second plunger causes the spike to pierce the pierceable membrane and push the second solution through the pierced membrane to mix with the first solution in the first area.

The present disclosure concerns a needleless injection device including a body forming a housing, a gas generator, a tubular reservoir which contains an active ingredient to be injected, and a generally T-shaped elastically deformable membrane. The membrane includes a tubular portion which extends axially in the reservoir and is designed to lie axially in the reservoir under the effect of the pressure generated by the gas generator. A nozzle for injecting the active ingredient is arranged at the lower end of the reservoir. The device further includes a sock which wraps the tubular portion of the membrane, at least partially. The sock is adapted to limit the friction between the tubular portion of the membrane and the reservoir.