A gas mixture apparatus includes a measurement control system, an activation system, a pressurized chamber with one or more gases, and a mixing chamber. A filter can be preattached to the outlet of the mixture apparatus, allowing excess gas to be discharged therethrough and then atmospheric air to be drawn into the mixture apparatus through the filter for creating a therapeutic gas mixture.

An integral injection molded strip (10) of a single plastic material is provided, the strip comprising a plurality of vials (20) connected by frangible (breakable) connecting members (38). Each vial (as molded as part of the integral injection molded strip) has a neck portion (30) with an internal delivery passage (31) and a squeezable body portion (22), the squeezable body portion having an internal chamber (23) for holding a single dose of a fluid product (50), the chamber (23) having an open top end (24) fluidly connected to the internal delivery passage (31) in the neck portion, and the chamber having a bottom end (25) adapted for filling with the fluid product. The internal delivery passage (31) (of the neck portion) has an open bottom end (33) fluidly connecting to the body chamber, an opposing open top end (32), and an integral injection molded internal membrane (34) (formed in the delivery channel during injection molding of the integral strip of vials) that seals the delivery passage (31) prior to being pierced by a needle (62) of a dispensing device (60).

A medicament packaging assembly for installation in a medicament delivery device is disclosed. The packaging assembly comprises a cartridge having a medicament chamber, a sealing element for sealing a distal end of the medicament chamber, a sealing element release member, a cannula and a removable cap member. The assembly is switchable from a starting configuration in which the release member is spaced from the sealing element to an activated configuration in which the release member cooperates with the sealing element to connect the medicament chamber to the cannula. The packaging assembly further comprises a first chamber defined in part by the cap member and arranged for receiving the cannula such that at least a distal end of the cannula is sealed in the first chamber when the cap member is in place, and a second chamber defined in part by the sealing element and arranged for receiving the release member.

Drug delivery devices and related methods of assembly are disclosed. The drug delivery device may include a container including a wall with an interior surface and a seal member with an end surface. The interior surface of the wall and the end surface of the seal member may define a reservoir filled with a drug. A fluid pathway assembly may be connected to the container and include an overmold member that covers a length of a container access needle and which defines an enclosed space with the seal member. The overmold member may be moveable relative to the seal member to carry the container access needle between a storage position, where a point of the container access needle is disposed exterior to the reservoir, and a delivery position, where the point extends through the end surface of the seal member into the reservoir.

The present invention provides a curved needle design which deflects to an advantageous angle when inserted within the medial posterior soft tissue of the patient lower jaw. The deflected needle tip is more perpendicular to the vertical wall of the posterior ramus and promotes the needle tip contacting bone proximate to the inferior alveolar nerve prior to injection of anesthetic. The needle design also improves the tactile feedback to the dental practitioner as the needle penetrates tissue and contacts bone.

A discharger for discharging fluid includes a sleeve, a discharge section, a carriage including a receiving space disposed therein, the carriage cooperating with a proximal end of the sleeve such that the carriage is moveable relative to the sleeve, and a piercing tip having a flow channel configured to establish a flow connection for the fluid from the receiving space to an inlet of the discharge section, the piercing tip having a shell surface, the piercing tip being integrally formed with at least a portion of the sleeve or formed as a unitary separate piece linked with at least the portion of the sleeve, the shell surface of the piercing tip having a convexly curved configuration, and the sleeve surrounding a proximal end of the discharge section and having an outer diameter that is substantially the same as the inner diameter of the carriage.

A multi-use needle assembly (200) for an injection device (50), wherein the injection device (50) comprises: a housing (52) and a cartridge (54) for storing a liquid drug for multiple injections, the multi-use needle assembly comprises: a support structure (201), needle cannula (210), a movable shield assembly comprising a movable shield (220) and an actuation member (222) fixed to the shield (220), and a cleaning assembly (230) adapted to change configuration by deformation. The shield (220) is adapted to be in a locked distal position, an unlocked distal position and an unlocked proximal position, and the cleaning assembly (230) is adapted to be configured in (i) an open configuration, wherein a gap is provided between an outer surface of the cannula (210) and the cleaning assembly (230) to allow adjustment of the relative axial position between the cleaning assembly and the cannula, (ii) a closed configuration, wherein the cleaning assembly (230) is configured to provide contact with the outer surface of the cannula to enable cleaning of the cannula. The actuation member (222) is adapted to deform and thereby operate the cleaning assembly (230) between the open and the closed configuration, in response to turning the shield between the unlocked and the locked configuration. The needle assembly (200) is adapted to enable cleaning of the cannula (210), when the shield (220) is in the locked distal position, and to allow exposure of the cannula (210), when the shield (220) is in the unlocked distal position.

An integrated structure of a preparation syringe includes a stretchable piston, a barrel, a needle, an exposed rubber plug, a sealing sheet, a built-in rubber plug, a sealing rubber plug and an engaging rubber plug. One end of the barrel is provided with the stretchable piston, and another end of the barrel is provided with a clamping column. The exposed rubber plug is provided on a side of the stretchable piston away from the barrel. The built-in rubber plug is provided within the barrel. A Scale mark is provided on a circumferential surface of the barrel. The sealing rubber plug is inlaid and sleeved on the clamping column. The sealing sheet is provided on a side of exposed tuber plug away from the barrel. A blunt end is provided at an end of the needle away form a needle tip. The engaging rubber plug is provided outside the blunt end.

Contemplated herein is a medication mixing device which can include a housing having therein a first chamber containing a first medicament component and a second chamber provided containing a second medicament component provided with a sealing structure selectively isolating the first chamber from the second chamber. The sealing structure can include a first sealing component having a first sealing interface and a second sealing component having a second sealing interface wherein a first compression force can be applied to the first and second sealing components causes the sealing interfaces to form a seal. The first compression force can then be configured to allow the first sealing component and the second sealing component to maintain at least one degree of freedom with respect to one another.

The present invention relates to a pre-filled disposable injection device and a needle cannula in combination. The prefilled disposable injection device (1) is made from a housing (2) containing a non-exchangeable cartridge (10) for storing a liquid drug sufficient for a number of injections. The proximal end of the pre-filled injection device (1) carries the dose setting button (3) and the distal end carries the needle cannula (20) having a lumen (21) through which the settable dose is expelled. The distal end (23) of the needle cannula (20) is covered by a telescopic needle covering shield (30) which shield (30) can operate between a first position covering the tip (24) of the needle cannula (20) and a second retracted position allowing an injection to be performed. The shield (30) carries a cleaner (50) which cleans at least the tip (24) of the needle cannula (20) between successive injections such that the prefilled injection device can be used without changing the needle cannula (20) during its life cycle.