The present specification discloses a solution delivery device having a container component and a plug component configured for selective engagement with the container component. The container component has an internal cavity including an elongated mixing channel containing a first constituent, and the plug component provides an internal flow path configured for introduction of a second constituent into the mixing channel for mixing with the first constituent. The plug component may be inserted within the container component partially in a first operational mode and fully in a second operational mode. The first constituent may be a drug and the second constituent a diluent, such that the drug may be lyophilized with the device in the first operational mode and reconstituted with the device in the second operational mode. Multiple devices may be employed in tandem for the co-delivery of multiple constituents. The device may be included in a kit or installed within an injector.

A novel device and method for intradermal delivery of an active agent is provided. The device comprises a housing which contains a reservoir chamber. A flexible reservoir containing the active agent is placed in the chamber. Upon pressure on an actuator the active agents is delivered via a hollow needle to the skin.

A valve (116, 216) for an injection device (100) is disclosed, which valve is arranged to provide a fluid communication between a drug-filled container (102, 202) and a drug distribution system (101) for distributing a drug to an injection site during use of the device, wherein the valve is substantially cylindrically shaped and is arranged to be at least partly positioned within an outlet portion (123, 223) of the container so that, in an initial configuration, the valve tightly closes the outlet portion, wherein the valve is arranged to be moved through a first distance in a first direction partly into the con-tainer, whereby fluid communication is established through the outlet portion of the container, and wherein the valve is further arranged to be moved through a second distance in a second direction opposite of the first direction. Furthermore, an injection device (100) comprising such a valve (116, 126) is disclosed.

The invention provides a syringe for dispensing a drug (1), comprising: a rigid syringe body, a first container (2), in contact with and enclosing the drug; and a second container (3), enclosing the first container, the second container being less gas permeable than the first container, wherein the second container partially or fully forms the rigid syringe body or is held within the rigid syringe body. The invention preserves the drug but allows the drug to be easily accessed without the need for a user to remove a gas barrier structure as a separate action in addition to the other actions needed to deliver the drug.

An injector device includes an elongate housing configured to receive container of medicament. The injector device also includes a needle sleeve mounted within the housing and moveable between an extended position in which the needle sleeve at least partially extends from the distal end of the housing, and a retracted position in which the needle sleeve is received further within the housing than in the extended position. The injector device also includes a release mechanism configured to control actuation of a piston rod. The release mechanism includes a rotatable member disposed within the housing and in cooperating engagement with the needle sleeve such that movement of the needle sleeve from the extended position to the retracted position causes the rotatable member to rotate within the housing from a first position to a second position.

A mixing and/or reconstitution system which simplifies the reconstitution and/or mixture of a first material and a second material compared to existing devices. Further it prevents user misuse. The mixing and/or reconstitution system comprisingan adaptor (100, 100, 100, 300),an integrated injection device (140, 340) removably attached to the adaptor (100, 100, 100, 300) comprising a switching element (155, 355),a first reservoir (121, 341) containing a first material, wherein the first material is a fluid, anda trigger (110, 126, 344), wherein the adaptor (100, 100, 100, 300) further comprises a first attachment location, e.g. a recess (101, 301), adapted to attach a vial (160, 360), wherein the vial (160, 360) contains a second material within a second reservoir (161, 361), wherein the second material contains a medicament formulation, a first connection element, e.g. a first needle (107, 307), a flow channel (108, 108a, 308) providing fluid communication of the switching element (155, 355) and the first connection element, a sensing arrangement (104, 117, 346, 385) for detecting a pre-defined position of the vial (160, 360) at the first attachment location, and an interlock element (114, 346) which is adapted to allow operating the trigger (110, 344) in order to establish a fluid communication between the first connection element and the first reservoir (121, 341) only if the sensing arrangement (104, 117, 346, 385) detects the pre-defined position of the vial (160, 360) at the first attachment location.

A fluid delivery manifold system assembled and configured to allow delivery of a single dose of a therapeutic agent (e.g., vaccine, drug, medicament, etc.) from a Blow-Fill-Seal (BFS) vial to a patient. The delivery assembly generally includes a modular manifold design consisting of separately constructed components cooperatively arranged and coupled to one another. The modular manifold construction allows for rapid manufacturing reconfigurations of one or more components with minimal costs to create new delivery manifold configurations that meet specific needs (i.e., different modes of delivery depending on agent to be delivered, such as subcutaneous, intramuscular, intradermal, intravenous injection, spray, or droplet delivery).

A fluid delivery injector comprises a syringe defining a barrel; a plunger and a hollow needle provided within the barrel adapted for linear movement parallel to a longitudinal axis with a distal tip of the needle contained within the syringe. A fluid retention reservoir is defined at least in the barrel and is in fluid communication with the needle when pressure is applied to the fluid in the reservoir and to the plunger for moving the needle out of the barrel. A spring may be provided for retracting the needle when pressure is released from the plunger.

The disclosure relates to a drug delivery device, comprising: an outer needle sleeve; a cartridge containing a dosage of a medicament and sealed with a sealing element that is arranged across an open distal end of the cartridge; a cartridge carrier adapted to hold the cartridge; a needle hub adapted to hold a double ended hollow needle; an inner needle sleeve arranged between the needle hub and the cartridge carrier; a removable cap coupled to the inner needle sleeve and adapted to cover and seal the needle; and a first locking mechanism adapted to lock the inner needle sleeve against axial movement in the proximal direction with respect to the cartridge carrier in an initial state, wherein in the initial state, the needle is spaced from the cartridge in the distal direction, and wherein the first locking mechanism is releasable by a rotational movement of the cap with respect to the outer needle sleeve.

A needle tip (22) for being connected and disconnected in use from a needle tip support (16), comprises a needle (24) having a forward end and a rearward end and, a connector secured to the needle intermediate its ends. The connector comprises two arms (28) each extending outwardly and rearwardly relative to the needle (16) and configured to be coupled and uncoupled in use from said needle tip support, and the arms are disposed on opposite sides of the needle. Also disclosed are arrangements for storing, dispensing and later disposing such needle tips, as well as coupling interfaces between the needle tip and a needle support cap to which it is fitted in use.