A fluid delivery device includes a housing having a bottom surface configured to be coupled to the skin surface. The fluid delivery device includes a cartridge prefilled with a fluid and configured to be inserted into the housing. The cartridge has a septum configured to be generally perpendicular to the bottom surface when the cartridge is inserted in the housing. The fluid delivery device includes a needle assembly that has a needle that includes a fluid coupling end and a delivery end. The fluid coupling end of the needle is fluidly disengaged from the cartridge in an initial position. The delivery end of the needle extends past the plane of the bottom surface and the fluid coupling end of the needle extends through the septum in a deployed position.

A device for mixing and delivering a solution includes a tubular barrel that includes a first end, a second end, and interior compartment. A first plunger is positionable at the first end of the barrel, is moveable within the interior compartment of the barrel, and includes a spike protruding into the interior compartment, the spike having an end configured for piercing a membrane. A second plunger is positionable within the barrel, is also moveable within the interior compartment of the barrel, and has a pierceable membrane. The second plunger and the second end form a first area within the barrel for housing a first solution to be mixed and the first and second plungers form a second area within the barrel for housing a second solution to be mixed. The first and second plungers are slidably arranged within the interior area of the tubular barrel such that moving the first plunger toward the second plunger causes the spike to pierce the pierceable membrane and push the second solution through the pierced membrane to mix with the first solution in the first area.

A wearable drug delivery device includes a housing, a needle assembly at least partially disposed in the housing, and a drive assembly at least partially disposed in the housing and coupled to the needle assembly. The needle assembly includes a needle or cannula and a sterile barrier disposed proximal to the needle or cannula in a first configuration where the sterile barrier is intact. The drive assembly includes a container that contains a medicament to be administered, a first plunger disposed in the container, and a drive mechanism that forces the first plunger to urge the medicament through the container. Upon engaging the drive mechanism, the needle or cannula and the sterile barrier move relative to each other from the first configuration to a second configuration where the needle or cannula breaks the sterile barrier, thereby allowing the medicament to be administered via the needle or cannula.

A system and method is provided for an injectable substance delivery pen comprising a microneedle hub assembly removably engaged with a pen device body which includes a cartridge, a plunger, and a drive mechanism. The hub assembly includes at least one microneedle for intradermal or shallow subcutaneous injection of the contents of the cartridge. The cartridge, plunger and drive mechanism components of the pen body are fabricated of non-compliant and non-compressible materials to allow effective communication of the cartridge contents via the microneedle patient interface.

A discharger for a fluid includes a housing having proximal and distal ends, a discharge device, the discharge device defining a passage between inlet and outlet openings, a carriage received in an end region of the housing and moveable relative to the housing between starting and discharge positions, in the starting position, the carriage protruding from the proximal end so as to be pushable into the housing and towards the discharge position, and the carriage defining a receiving space to be loaded with a separate container holding a fluid to be discharged, and an activation device configured to establish a flow connection for the fluid from within the receiving space to the inlet opening, the activation device being inoperative when the carriage is in the starting position and with the activation device establishing the flow connection when the carriage is in or being moved toward the discharge position.

An injector device comprises a needle support member for supporting a distal end of a needle within a collar region of the device. On insertion of the neck of a drug cartridge into the collar region, the tip of the needle pierces a septum in the drug cartridge and is thereafter supported by the septum. The needle support member is then displaced by the drug cartridge as it moves further into the collar region. The displacement may comprise hinging or sliding of the support member. By supporting the needle as it pierces the septum and by providing controlled resistance to rapid or violent insertion of the drug cartridge, the needle support member enables a single, fine needle to be used for both the distal end and the proximal end without buckling, even if the needle is curved so that the two ends are mutually inclined.

A self-admixing disposable hypodermic needle (admixing needle) includes a reservoir containing an additive, such as a buffering agent, to facilitate homogeneous mixing of the additive with an injection fluid, such as Lidocaine, contained in a cartridge held within a mechanically conjoined syringe. The admixing needle establishes a fluid communication pathway for hypodermically delivering the injection mixture to a patient preceding a potentially painful dental or medical procedure. Prior to removal, a delivery needle cap is pushed toward the syringe to dispense the additive into the cartridge. The delivery needle is then placed within the patient's tissues and the syringe is operated to force the injection mixture from the cartridge. Mixing surfaces on the male body (reservoir plunger) and the female body (reservoir) and other mechanical features homogeneously combine the injection fluid with the additive as the injection mixture travels through the admixing needle during the hypodermic injection.

A gas mixture apparatus includes a measurement control system, an activation system, a pressurized chamber with one or more gases, and a mixing chamber. A filter can be preattached to the outlet of the mixture apparatus, allowing excess gas to be discharged therethrough and then atmospheric air to be drawn into the mixture apparatus through the filter for creating a therapeutic gas mixture.

An autoinjector is described that includes an outer body, a first trigger, an output needle, and a first compartment. The first compartment is positioned within the outer body and includes (i) a main body, (ii) a first biasing member coupled to the first trigger, and (iii) a protrusion positioned at a distal end of the main body. The autoinjector further includes a second compartment positioned in the outer body and in fluid communication with the first compartment and the output needle. The autoinjector also includes a second biasing member coupled to a second trigger. The first biasing member is configured to, upon application of force to the first trigger, automatically move an ampule in a distal direction relative to the main body to force the ampule against the protrusion, so as to break the ampule and allow a medicament to flow from the ampule to the second compartment.

A primary packaging container for pharmaceuticals is provided. The container includes a hollow body, an opening, and a closure. The hollow body has an opening and is made of a cycloolefin polymer or a cycloolefin copolymer. The closure has a puncture region. The closure closes the opening with the puncturing region at the opening. The puncturing region is configured to allow introduction of a cannula into the hollow body and resealing the hollow body upon withdraw of the cannula. The closure has an elastomer that is connected to the hollow body so as to be not separable in a non-destructive manner.