A device for transferring fluids in a closed system transfer device using flash for last drop extraction and to reduce coring. The device including a piercing member having a distal end and a proximal end and defining a longitudinal fluid channel. A first opening positioned at the distal end of the piercing member wherein the first opening is in fluid communication with the longitudinal fluid channel. A cover or flash positioned over the first opening. The cover including a pre-cut pattern wherein the cover opens along the pre-cut pattern upon application of a distally directed force from the longitudinal fluid channel. The distal end including the first opening having a steep taper to facilitate last drop extraction.

Embodiments of medical devices and methods are disclosed. The medical devices typically comprises a needle with a rigid proximal shaft, a flexible distal shaft and a distal tip. The distal tip includes an electrode for delivering energy to puncture a tissue. In some embodiments, the distal shaft comprises a superelastic material. In other embodiments, the distal shaft is comprised of both a superelastic material and a non-superelastic material.

A pre-filled syringe is disclosed, comprising a barrel and a plunger, the barrel having an outlet, the barrel containing a pharmaceutically acceptable solution having a non-physiological pH, wherein the syringe further comprises an ion exchange material. The ion exchange material is provided at a position to allow contact with the pharmaceutically acceptable solution upon ejection of the pharmaceutically acceptable solution from the barrel via the outlet. The ion exchange material is capable of adjusting the pH of the solution from a non-physiological pH, at which the pharmaceutically acceptable solution is stored in order to ensure acceptable shelf life, to a more physiological pH at which the discomfort and/or pain experienced during injection may be alleviated.

A needle assembly includes a needle, a rear needle cap and a front needle cap. The needle includes a needle hub and a needle shaft running through and attached to the needle hub. The shaft incorporates two sharp ends and an internal channel running through the entire length of the shaft. The needle hub includes a rear needle body and a front needle body. The rear needle cap is adapted to be attached to the rear needle body and the front needle cap is adapted to be attached to the front needle body. The front needle body incorporates a guiding channel and a locking receptacle connecting to and extending from the guiding channel in a needle detachment direction. The front needle cap includes an internal locking plug adapted to move along the guiding channel and be disposed inside the locking receptacle. The front needle cap also incorporates a funnel lip.

A plungerless aspiration and/or injection device and a method of using the same are disclosed herein. The plungerless aspiration and/or injection device includes a housing; a needle portion disposed in the housing, the needle portion configured to be selectively retracted and extended by a user, the needle potion comprising a needle tip configured to be inserted into tissue of a patient for aspiration, injection, and/or implantation; and a bulb portion disposed in the housing, the bulb portion defining a fluid containing cavity that is fluidly coupled to the needle portion, and the bulb portion being elastically deformable so that the user is able to perform the aspiration, the injection, and/or the implantation on the patient by manipulating the bulb portion.

Disclosed herein is a system, apparatus and method directed to a magnetizer comprising at least one magnet; and a housing, the housing comprising: a top face; a bottom face positioned on an opposite side of the housing from the top face; a plurality of faces adjoining the top face and the bottom face; an interior comprising an interior surface formed at least in part by the top face, the bottom face and the plurality of faces; wherein the top face includes a first opening configured to receive a medical device; and wherein the at least one magnet is positioned within the interior of the housing. A face of the plurality of faces may include a second opening to expose at least a portion of the interior surface through the second opening. The second opening may be larger than the first opening.

A device for intraosseous injection is provided which can accurately, quickly, and safely introduce desired fluid into a patient's bone marrow. The intraosseous injector includes a housing, a container located within the housing, a hollow needle, and a valve. The intraosseous injector may further include a release mechanism comprising a bone probe needle and a movable release member. The intraosseous injector may include a depth limiter mechanism operable to limit a depth of penetration of the needle relative to a surface of a bone. A method for intraosseous injection is also provided.

The invention relates to sensing compositional information about material by measuring thermal properties of the material. In one arrangement there is provided a needle probe for sensing compositional information. The probe comprises a needle having a tip region. A resistive element is attached to the needle at the tip region. A measurement system is configured to: 1) drive an electrical current through the resistive element to apply heating to the resistive element, and 2) measure an electrical response of the resistive element to the heating. A processing unit analyses the measured electrical response of the resistive element to the heating to determine compositional information about material in contact with the tip region.

A delivery tool connectable with a syringe can be used to deliver a viscoelastic solution. The tool includes a first segment, a second segment and an inner lumen defined by the first and second segments. A distal portion extends from the second segment in a curved manner.

The present disclosure provides a method of treating edema in a subject in need thereof, comprising the step of administering a composition that comprises a protein having hyaluronidase activity to a region of the subject having edema.