A mixing and delivery system includes a compressible tube and a mixing apparatus. The compressible tube includes a reservoir configured for mixing and holding a surgical substance, an inlet portion for accommodating introduction of an element of the surgical substance into the compressible tube, and an exit port for enabling the delivery of the surgical substance to a target portion of an anatomy. The mixing apparatus is configured to be received through the inlet portion of the compressible tube for mixing elements of the surgical substance to form the surgical substance.

A method for preparing a pre-filled multi-chamber injection system includes providing an injection system body, the injection system body defining an open proximal end, a body interior, and an open distal end. The method also includes introducing a first substance into a distal end of the body interior. The method further includes disposing a distal stopper member in the body interior, the distal stopper member and the injection system body defining proximal and distal chambers in the body interior. Moreover, the method includes introducing a second substance into the body interior. In addition, the method includes disposing a proximal stopper member in the body interior. The method also includes inserting an elongate member at least partially into the body interior, the elongate member having a plurality of flow channels for fluidly coupling the proximal and distal chambers. The method further includes coupling a plunger member to the proximal stopper member.

A fluid delivery injector comprises a syringe defining a barrel; a plunger and a hollow needle provided within the barrel adapted for linear movement parallel to a longitudinal axis with a distal tip of the needle contained within the syringe. A fluid retention reservoir is defined at least in the barrel and is in fluid communication with the needle when pressure is applied to the fluid in the reservoir and to the plunger for moving the needle out of the barrel. A spring may be provided for retracting the needle when pressure is released from the plunger.

An injection needle has an opening at a distal end thereof the injection needle and defines a hole. An optical fiber is configured to output a light from a light source and inserted in the hole. The optical fiber has a distal end positioned on an inner side of the opening. A protector is configured to transmit the light and is positioned further towards an opening side of the injection needle than the distal end. The protector is configured to prevent adherence of tissue to the optical fiber. The light emitted from the optical fiber is configured to irradiated onto a treatment target in a state in which the injection needle is inserted into skin, the distal end is positioned on an inner side of the opening, and the protector is positioned further towards the opening side of the injection needle than the distal end.

The invention relates to syringes for storing and mixing components.

A computerized electro-mechanical drug delivery device configured to deliver at least one dose of two or more medicaments. The device comprises a control unit. An electro-mechanical drive unit is operably coupled to the control unit and a primary reservoir for a first medicament and a secondary reservoir for a fluid agent, e.g. a second medicament. An operator interface is in communication with the control unit. A single dispense assembly is configured for fluid communication with the primary and the secondary reservoir. Activation of the operator panel sets a first dose from the primary reservoir and based on the first dose and a therapeutic dose profile, the control unit is configured to determine a dose or range of the fluid agent. Alternatively, the control unit determines or calculates a dose or range of a third medicament. Further, a dispense interface for use with a drug delivery device is disclosed.

A method of mixing and delivering a substance to a bone includes providing a compressible tube having a reservoir and using a mixing apparatus to mix a particulate solid and a mixing liquid to form the substance within the reservoir of the compressible tube. The method further includes using a compressing device to move the substance through an exit port in the compressible tube for delivery to the bone. The compressing device may be positioned on the compressible tube and the method may further include moving the compressing device along the compressible tube to empty the substance from the compressible tube. The substance may be a bone void filler, and the substance may be delivered from the exit port in the tube through a delivery apparatus, such as a cannula, to a target portion of the anatomy.

Provided are rapidly cross-linkable silicone compositions, systems, kits, and methods for filling implanted medical devices in situ, the implanted medical devices, including for example, body implants and tissue expanders, the compositions including a platinum divinyl disiloxane complex; a low viscosity vinyl terminated polydimethylsiloxane; a low viscosity hydride terminated polydimethylsiloxane; and a silicone cross-linker, where the rapidly cross-linkable silicone composition has a viscosity of 150 cPs for 1 min. post-preparation and 300 cPs5 min. post-preparation, at ambient temperature.

Provided are rapidly cross-linkable silicone foam compositions, kits, and methods for filling implanted medical devices in situ or in vivo, the implanted medical devices, including for example, body implants and tissue expanders, the compositions including a platinum divinyl disiloxane complex; a low viscosity vinyl terminated polydimethylsiloxane; a low viscosity hydride terminated polydimethylsiloxane; a silicone cross-linker; and a gas and/or gas-filled microcapsules, where the rapidly cross-linkable silicone foam composition has a viscosity of 150 cPs for 1 min. post-preparation and 300 cPs5 min. post-preparation, at ambient temperature.

A portable dual chamber auto-injector configured to store a dry opioid antagonist medicament separately from a liquid component, wherein a user actuated mixing system comprising a movable component to create a fluidic pathway between the first and second chambers and release a portion of energy from a pre-stored energy to drive a displacement mechanism into the first chamber and displace the liquid component into the second chamber and solubilize the opioid antagonist. A needle assembly in fluid communication with the second chamber can be used to transfer the solubilized opioid antagonist.