The present invention provides methods and a BFS/FFS system for delivering either one or more substances within at least one body cavity, characterized by a vial comprising V.sub.sub [ml] of said substances; said vail selected from a pierceable container, a blow-fill-seal and a form-fill-seal, having fluid inlet and a fluid discharging outlet of diameter D [mm], configured for placement in proximity to said body cavity; said fluid inlet configured by means of size and shape to interface in a sealable manner a puncturing member, configured to, upon coupling to said fluid inlet, piercing the same, thereby providing said substances in a fluid communication, via a valve, with a chamber configured to accept pressurized fluid at volume V.sub.PF [ml] and pressure P.sub.PF [barg]; said valve is commutable from an CLOSE to an OPEN CONFIGURATION within a short period of time, <500 milliseconds (dT); at said OPEN CONFIGURATION, said pressurized fluid flows from said chamber, via said fluid inlet, entrains said substances by one of the followings: (i) one portion m.sup.V.sub.PF/n, n=portion (%, v/v), m=1, (ii) a plurality of portions, m.sup.V.sub.PF/n, m2, or (iii) the whole V.sub.PF, n,m=1 erupts via said fluid discharging outlet to within said body cavity.

The multi-chambered well dosage form and device disclosed herein can be single or multi dose capable for administration of pharmaceuticals of a range of particle sizes. The present dosage devices and systems provide for improved efficiency and patient ease of use owing to its compact size and simple design, low cost, and consistent, contamination free dosing of dry powder medicaments or other agents. The present disclosure provides a multi-chambered dosage form containing dry powder medical composition containing chamber well with an internal piercing device and one or more adjacent gas-filled chamber wells to aid the dispense of the powder contents to the user and in certain embodiments, without the requirement of an external energy sources common with active devices known in the art. Said methods, systems and devices provide increased ejection fraction and hence greater efficiency of drug delivery above that as provided by current devices.

A fluid dispenser device with a main body (10); a reservoir (21) containing a dose of powder; a reservoir opening mechanism (80); a dispenser orifice (5); a movable support mechanism (50) to displace a reservoir (21) against the opening mechanism on actuation and displaceable between a non-dispensing position and a dispensing position, urged towards the dispensing position, and held in the non-dispensing position by a blocking mechanism (100). An inhalation trigger system (60) is provided that has a deformable air chamber (61) and a trigger element (600) that co-operates firstly with the air chamber (61) and secondly with the blocking mechanism. The fluid dispenser device further includes an electronic dose counter or indicator device (300) including a sensor (306) to detect displacement or deformation of a portion of the fluid dispenser device, generated while the user is inhaling or after the user has inhaled.

A beneficial agent dispensing device comprises a dispenser body comprising a pressure chamber and at least one dispensing port. A flexible primary container stores the beneficial agent contained within the body. The arrangement is such that pressure in the pressure chamber depress the flexible primary container to expel the beneficial agent through the dispensing port. The beneficial agent dispenser can be configured to deliver the beneficial agent intranasally.

A consumable cartridge is provided in connection with an inhaler device 10. The consumable cartridge includes a casing defining a cavity, the casing having a first region and a second region. An elastic bladder is located within the cavity of the casing and encloses a vaporizing liquid. The first region of the casing includes a pierceable portion, and the second region includes a pre-perforated portion. The bladder is disconnected from the casing in the first region, and is configured to rupture or to be cut when it is pierced by a piercing member of the inhaler device such that the ruptured or cut area of the bladder creates an opening which is significantly larger than the cross sectional area of the piercing.

A unit dose container for the containment of an intranasal formulation for use with the POD device.

The invention relates to an internal seal system. The internal seal may be incorporated into a pre-filled, small-volume nebulizer assembly with a T-connector. The small-volume nebulizer may be pre-filled with at least one unit-dose of medicine and hermetically sealed until use by an input port seal and the internal seal. The internal seal may operate as a valve when the assembly is changed into a second configuration.

The present invention relates to a medical device for intranasal delivery of a medicament. The medicament may be any type of medicament suitable for nasal administration and delivery in the form of a spray. The present invention ensures that a complete dosage of the medicament is delivered, especially to specific areas in the nasal cavity, such as the rear of the nasal cavity where the SPG is located.

A method of assembling an inhaler article holder having an oriented piercing element, includes inserting an inner housing into a jig. The inner housing extends along a longitudinal axis from a proximal end to a distal end an inner housing length. The distal end includes a piercing element aperture. The inner housing length mates with a jig opening. The jig includes a jig angled planar surface coaxial with the piercing element aperture. The method includes mating a piercing element cutting plane with the jig angled planar surface. The piercing element extends from a proximal cutting end to the piercing element distal end defining a cutting plane. The piercing element distal end is received in the inner housing piercing element aperture, and then fixing the piercing element distal end to the inner housing. The piercing element cutting plane is orientated relative to the inner housing longitudinal axis.

This aerosol generation system including an elongated heat generation unit that, when energized, generates heat to heat an aerosol generating substrate from the inside thereof; and a pair of metal plates disposed to respectively cover the facing surfaces of the heating unit along the elongated shape. The electrical resistance value of the heating unit in the direction in which the pair of metal plates faces each other is 100 to 1400 times the electrical resistance value of each of the pair of metal plates in the longitudinal direction of the elongated shape.