Disclosed herein are methods, systems, and devices for controlling a gas mixture within a mechanical ventilator. According to one embodiment, a computer implemented method includes receiving first peripheral arterial oxygen saturation (SpO.sub.2) data from a pulse oximeter via a pulse oximeter interface, wherein the pulse oximeter is configured to monitor a patient receiving invasive ventilation; determining a first mode of operation for a ventilator mechanism, wherein the ventilator mechanism is configured to provide at least a portion of the invasive ventilation; determining first partial pressure of oxygen (PaO.sub.2) data stored in a first lookup table using the first SpO.sub.2 data, wherein the first lookup table is derived from a sigmoid shaped oxyhemoglobin dissociation curve; determining first fraction of inspired oxygen in air (FiO.sub.2) data for setting a mixture in a gas blender in the ventilator mechanism based on the first PaO.sub.2 data and a variable offset; and providing the FiO.sub.2 data to the ventilator mechanism.

A method of determining a duration of safe apnoea. Information is obtained relating to a respiratory indicator, which can include information relating to a potential respiratory equilibrium, and a duration of safe apnoea is determined from the obtained information.

Systems and methods for hypoxia delivery are provided. An apparatus for providing intermittent normoxia and hypoxia intervals includes a breathing component, a normoxia fluid source, a hypoxia fluid source, a valve, and a control system. The valve is configured to disrupt flow from at least one of the normoxia fluid source and the hypoxia fluid source and the control system is configured to cause the at least one valve to switch between delivery of fluid from the normoxia fluid source and the hypoxia fluid source while maintaining positive pressure at the breathing component.

A system for assessing extubation includes a respiratory assistance device, an artificial intelligence platform, and a hospital information system. The respiratory assistance device is adapted to communicate with a trachea of a patient. The artificial intelligence platform includes a prediction module. A method for assessing extubation includes the following steps. Measured values of respiratory parameters of the patient are recorded by the respiratory assistance device. The recorded times and the measured values of the respiratory parameters corresponding to each of the recording times are transmitted to the artificial intelligence platform. The prediction module analyzes the measured values of respiratory parameters within a predetermined time period according to a prediction model to generate a prediction result. The prediction result is transmitted to the hospital information system and is recorded into a medical record of the patient. With such design, a reference for extubation assessment that is more accurate is provided.

Embodiments of the innovation relate to a ventilator, comprising: a positive displacement pump having a drive motor and configured to output a predetermined volume of inspiratory gas for each rotation of an output shaft of the drive motor; at least one pressure sensor configured to measure inspiratory pressure; and a control unit having a controller comprising a memory and a processor, the control unit disposed in electrical communication with the drive motor and with the at least one pressure sensor. The controller is configured to: receive at least one of an operation signal and a pressure sensor signal, and transmit a drive motor control signal to the drive motor to adjust at least one of a rotational speed of the output shaft and a number of rotations of the output shaft based upon the at least one of the operation signal and the pressure sensor signal.

A method of treating a human subject which is effected by inhalation of gaseous nitric oxide, the method comprising a first treatment period comprising administering gNO by inhalation over a period of about at least 5 days, wherein the first treatment period is followed by a second treatment period comprising administering gNO by inhalation over a period of at least 3 months. The method can be utilized for treating a human subject suffering from, or prone to suffer from, a disease or disorder that is manifested in the respiratory tract, or from a disease or disorder that can be treated via the respiratory tract.

A detection device for detecting characteristics of a mixed fluid containing different types of substances with different thermal properties within a prescribed range, includes: one or a plurality of heaters for heating the mixed fluid; a plurality of temperature detectors for detecting the temperature of the mixed fluid heated; a flow rate calculation unit for calculating the flow rate of the mixed fluid using the output from at least a portion of the plurality of temperature detectors; a correspondence relation storage unit that stores the correspondence relation between the output from the temperature detectors for a prescribed flow rate and the mixture ratio of the substances in the mixed fluid; and a mixture ratio calculation unit for calculating the mixture ratio of the substances in the mixed fluid on the basis of the output from the temperature detectors and the correspondence relation.

An apparatus (1) for supplying a gas mixture to a patient, having a gas inlet line (30) with a gas inlet orifice (30a) that splits into a first gas line (31) and a second gas line (32); at least one permeation module (33) arranged on the second gas line (32), the said permeation module (33) having a feed port (33a) in fluidic communication with the second gas line (32), a retentate port (33b) and a permeate port (33c); a third gas line (34) in fluidic communication with the retentate port (33b) of the permeation module (33); a fourth gas line (35) in fluidic communication with the permeate port (33c) of the permeation module (33), and coupling fluidically to the said first gas line (31); and a source (360) of air in fluidic communication with the first gas line (31) and the fourth gas line (35).

Methods and apparatus provide controlled operations in an oxygen concentrator (100) such as by adjusting valve opening time to regulate amount of oxygen enriched air released to a user. The apparatus may generate, with a sensor configured to sense pressure at a location associated with accumulation of enriched air produced by the concentrator, a signal representing measured pressure of the accumulated enriched air. The apparatus may generate, with a sensor, a signal indicative of respiration of a user of the concentrator. The apparatus may include a controller configured to receive the measured pressure and respiration signals. The controller may control, responsive to the respiration indication and according to a target duration, actuation of a valve adapted to release a bolus of accumulated oxygen enriched air. The controller may dynamically determine the target duration during the release of the bolus according to a function of a value of the measured pressure.

A high flow therapy system for delivering heated and humidified respiratory gas to an airway of a patient includes a respiratory gas flow pathway for delivering the respiratory gas to the airway of the patient by way of a non-sealing respiratory interface; wherein flow rate of the respiratory gas is controlled by a microprocessor, a mixing area for mixing a first gas and a second gas in the respiratory gas flow pathway, a humidification area downstream of the mixing area and configured for humidifying respiratory gas in the respiratory gas flow pathway, and a heated delivery conduit for minimizing condensation of humidified respiratory gas.