Rapidly insertable central catheters (“RICCs”) and methods are disclosed. A RICC can include a first section of a first polymeric material in a distal portion of a catheter tube, a second section of a second polymeric material proximal of the first section, and a tapered junction therebetween. The first polymeric material has a first durometer. The second polymeric material has a second, lesser durometer. The junction is formed of the second polymeric material or a third polymeric material having a third durometer closer to the second durometer than the first durometer. The first section has a proximal portion disposed in a receptacle of the junction. An abluminal surface of a distal portion of the junction smoothly transitions onto an abluminal surface of the proximal portion of the first section without an edge that catches on skin when the RICC is inserted into an insertion site of a patient.

A method for delivering a therapeutic agent to a tumor through a target vessel includes delivering the therapeutic agent through a lumen of a catheter which has been coated or otherwise structured to reduce the wall shear stress during delivery of the immunotherapy and by generating turbulent flow during the delivery of the therapeutic agent.

An apparatus and method for preventing stroke by occluding blood flow through the carotid arteries and a left subclavian artery of a patient is provided. The apparatus has a first occluding catheter that carries a first occluding balloon that has an inflated configuration that occludes one of the carotid arteries. The apparatus also includes a second occluding catheter that carries a second occluding balloon that has an inflated configuration that occludes the other one of the carotid arteries. A third occluding balloon is present, that could be on an insertion device, that may occlude the left subclavian artery.

The disclosure relates generally to the field of medical devices for accessing body lumens. In an embodiment, a catheter may comprise a shaft comprising a proximal end, a distal end, an actuating portion proximal to the distal end, and a first lumen extending along a length of the shaft between the proximal and distal ends. A plurality of slots may be disposed and spaced-apart from each other along the actuating portion. The plurality of slots may extend radially into the first lumen.

A catheter may include electrodes for transvascular nerve stimulation. The electrodes may be positioned within lumens of the catheter and aligned with apertures in the outer wall of the catheter. The electrodes may produce focused electrical fields for stimulation of one or more nerves. In one embodiment, the catheter may include a set of proximal electrodes and a set of distal electrodes, and the proximal electrodes may stimulate a patient’s left phrenic nerve and the distal electrodes may stimulate a patient’s right phrenic nerve.

Devices for revising and replacing an implanted device are disclosed, which include a first lumen having a neck portion, a first aperture that opens to the neck portion of the first lumen, and a flap having a top edge, a bottom edge, a second aperture, and first and second lateral edges extending between the top and bottom edges. The neck portion of the first lumen is configured to receive a new guidewire inserted through the first aperture. The lateral edges of the flap are folded around an implanted device to form a second lumen in the bottom portion of the device, and a new guidewire inserted into the first lumen through the first aperture. The devices allow for the successive and nearly simultaneous revision and replacement of an implanted device.

A catheter that has a catheter tube everting inside-out during the process of catheterization. The catheter tube has a plurality of longitudinal protrusions extending from the first end of the catheter tube through at least a portion of the catheter tube, and forming an angle of 0 degrees to 45 degrees with respect to the longitudinal axis of the catheter tube and facing radially inwards, and provides for dilating a circumference of the catheter tube upon everting the catheter tube inside-out from the first end of the catheter tube.

A system for aspirating thrombus including an aspiration catheter having a supply lumen, an aspiration lumen, and a first connector hydraulically coupled to the proximal end of the aspiration lumen, and a pressure sensor having an internal passageway and having a distal connector configured to hydraulically couple to the first connector, a proximal connector configured to couple to a vacuum source, and a valve disposed between the distal connector and the proximal connector, the valve having an open state and a closed state.

A catheter configured to provide a delivery system for standard interventional devices and for rapid localized deep cooling to organs at risk of ischemia-reperfusion injury during procedures such as intracranial thrombectomy or emergency thrombectomy. The catheter is comprised of an insulative shaft with a multi-component braided outer lumen and an internal floating inner lumen with a plurality of structures configured to minimize contact and resulting heat transfer between the two lumens.

A vascular access device may be an integrated catheter. The vascular access device includes a catheter and catheter adapter having a catheter hub and side port. The contact angle of a probe is greater than 90 degrees. The entrance angle of a probe entering the catheter hub from the side port may be less than 45 degrees. The vascular access device may include a component configured to direct the path of a probe towards the catheter opening. The component may be a protrusion extending into the lumen of the side port, internal fluid passageway, and/or extension tube, or a septum within the catheter hub. The vascular access device includes an access adapter in fluid communication with the side port and permitting insertion of a probe into the catheter through the side port with or without a separate luer adapter. Methods of using a vascular access device are further disclosed.