Atrial appendage occlusion systems are provided, such systems including a first device and a second device. The first device has a first tube sized and shaped for insertion into the heart and a balloon coupled thereto. The second device has a second tube sized and shaped for insertion into a pericardial space surrounding the heart, and has a lumen extending at least partially from a second tube distal end to a second tube proximal end. The second device also includes a loop sized and shaped to fit at least partially within the lumen of the second tube, with the loop configured for protraction from the second tube distal end and for placement, and to be tightened and secured around, the atrial appendage.

A rectal injection device and a method of operating a rectal injection device. In one embodiment, the device includes: (1) a handle having a trigger associated therewith, (2) an extension tube extending from the handle and terminating in a head, (3) at least two needles coupled to the head and configured to move relative thereto between a retracted position and a deployed position and (4) a pullrod coupling the trigger and the needles and configured to cause the needles to move.

A steerable endoscope system includes a continuum manipulator, a plurality of syringes, and a steerable tip. The continuum manipulator includes a plurality of spaced discs and a plurality of backbones each extending through all discs. A bending movement of the continuum manipulator changes a varying linear displacement of each backbone. Each backbone is further coupled to a different one of the syringes such that the linear displacement of each backbone pushes or pulls a piston of the corresponding syringe by a varying amount. The steerable tip includes a plurality of bellows each pneumatically coupled to a different syringe such that movement of the piston of a syringe causes the corresponding bellow to inflate or deflate. Because the distal end of each bellow is fixedly coupled to the same end effector, variations in the amount of inflation or deflation on each bellow causes a bending of the steerable tip.

An imaging system and device used either alone or in conjunction with an intravascular treatment device to deliver a therapeutic agent to soft tissue within a subject.

An external imaging system used either alone or in conjunction with an intravascular treatment device to deliver a therapeutic agent to soft tissue within a subject.

The present invention describes a method for performing a prostate surgical treatment, said method comprising: arranging a catheter 1 inside of a urethra of a patient and anchored against the bladder neck of the patient subsequent to the filling of the balloon stopper unit 5 with a fluid when the balloon stopper unit 5 is arranged inside of the bladder of a patient;
said method also comprising injecting at least one anesthetic agent and adrenaline or injecting botulinum toxin (Botox) and/or penicillin to the prostate via the injection tube 9 and the hollow tip 10 at an intended position of the prostate. Moreover, the present invention also refers to a kit comprising a catheter 1 according to the present invention and one or more syringe(s) 1000 containing adrenaline and at least one anesthetic agent and/or at least a syringe 1000 or vial containing botulinum toxin (Botox) and/or penicillin.

Percutaneous therapy or drug delivery devices are described herein. The device can include one or multiple lumens inside a cannula or catheter body. The device can include features for reducing or preventing backflow or reflux of infusate along the device insertion track, such as one or more bullet noses, over tubes, and/or micro-tips. The device can be used in any of a variety of treatment methods, including to inject cancer therapy medicinal products directly into pulmonary tumors or tumors located in other regions of the body. The device can include features to keep the distal tip secure during patient respiration or during other patient movement, and can reduce the incidence of reflux during therapy delivery.

A catheter-based/intravascular fluid injection system with application to renal denervation includes a multiplicity of needles which expand open around a central axis to engage the wall of a blood vessel, or the wall of the left atrium, allowing the injection of a cytotoxic and/or neurotoxic solution for ablating conducting tissue, or nerve fibers around the ostium of the pulmonary vein, or circumferentially in or just beyond the outer layer of the renal artery. The expandable delivery system includes expandable components that facilitate positioning of a multiplicity of injection needles against the inside wall of a blood vessel from where they can be advanced. The system also includes means to limit and/or adjust the depth of penetration of the ablative fluid into the tissue of the wall of the targeted blood vessel.

A needle catheter for injecting a drug is provided, the needle catheter includes a needle assembly for discharging a drug, a drug supply tube for supplying the drug to the needle assembly, and a drug regulation handle for regulating an amount of the drug to be supplied through the drug supply tube, wherein the needle assembly includes a first needle communicatively coupled to the drug supply tube and a second needle coupled to the drug supply tube in parallel with the first needle, and the first needle and the second needle are contact-coupled to each other by a partition wall.

Methods and apparatus are provided for treatment of heart arrhythmia via renal neuromodulation. Such neuromodulation may effectuate irreversible electroporation or electrofusion, ablation, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, such neuromodulation is achieved through application of an electric field. In some embodiments, such neuromodulation is achieved through application of neuromodulatory agents, of thermal energy and/or of high intensity focused ultrasound. In some embodiments, such neuromodulation is performed in a bilateral fashion.