A catheter-based/intravascular fluid injection system with application to renal denervation includes a multiplicity of needles which expand open around a central axis to engage the wall of a blood vessel, or the wall of the left atrium, allowing the injection of a cytotoxic and/or neurotoxic solution for ablating conducting tissue, or nerve fibers around the ostium of the pulmonary vein, or circumferentially in or just beyond the outer layer of the renal artery. The expandable delivery system includes expandable components that facilitate positioning of a multiplicity of injection needles against the inside wall of a blood vessel from where they can be advanced. The system also includes means to limit and/or adjust the depth of penetration of the ablative fluid into the tissue of the wall of the targeted blood vessel.

A fluid delivery catheter that uses micro-needles for fluid delivery though a vessel wall. The catheter may provide fluid delivery therapy for various procedures, such as, for example, delivery of tumescent fluid or renal denervation. The catheter includes an elongate member with deployable and retractable needles disposed about a distal end of the elongate member. The needles may be disposed radially about the distal end and/or along a length of the distal end.

A rectal injection device configured to inject a liquid into the tissues around the internal anal sphincter of a rectum. The rectal injection device comprises: i) an elongated tube having a distal end and a proximal end; ii) a rounded head coupled to the distal end of the elongated tube; iii) a needle extending from the proximal end of the elongated tube into the rounded head, wherein a tip of the needle is aligned with a hole in the rounded head; and iv) an actuator mechanism configured to move the needle to a deployed position in which the tip of the needle extends through the hole and into the anal tissues and to move the needle to a retracted position in which the tip of the needle is withdrawn within the rounded head.

A rectal injection device and a method of operating a rectal injection device. In one embodiment, the device includes: (1) a handle having a trigger associated therewith, (2) an extension tube extending from the handle and terminating in a head, (3) at least two needles coupled to the head and configured to move relative thereto between a retracted position and a deployed position and (4) a pullrod coupling the trigger and the needles and configured to cause the needles to move.

A catheter (102) includes an elongate body (108) extending from a proximal end to a distal end, a distal portion (108b), and a therapeutic assembly (112) at the distal portion of the elongate body, wherein the therapeutic assembly comprises a chemical chamber configured to supply a predetermined volume of chemical agent to tissue adjacent the therapeutic assembly.

An injection catheter system that includes (a) an actuator; (b) an outer needle comprising a sharp tip and a tubular body defining a lumen, and extending distally from the actuator; and (c) an inner needle at least partially disposed within the lumen and extending distally from the actuator, the inner needle having a distal tip configured such that at least a portion of the distal tip has a surface contour with an interstitial cavity adapted to receive a therapeutic gel. The system is configured such that (a) in a first position, the distal tip is fully disposed within the lumen to temporarily retain the therapeutic gel in the interstitial cavity and (b) in a second position, the outer needle is retracted proximally, exposing the interstitial cavity to deliver the therapeutic gel to a target area in a body.

A rectal injection device and a method of operating a rectal injection device. In one embodiment, the device includes: (1) a handle having a trigger associated therewith, (2) an extension tube extending from the handle and terminating in a head, (3) at least two needles coupled to the head and configured to move relative thereto between a retracted position and a deployed position and (4) a pullrod coupling the trigger and the needles and configured to cause the needles to move.

A microneedle skin care device includes a housing having a predetermined space formed therein; a sound wave module disposed inside the housing to provide sound wave vibration; a microneedle assembly configured to receive vibration of the sound wave module and vibrate in front and rear directions, the microneedle assembly having microneedles disposed at a front end; and a needle tip coupled to the front end of the microneedle assembly and having through-holes through which the microneedles selectively pass through formed corresponding to the microneedles.

In some examples, a medical system for delivering a chemical agent into a perivasculature of a patient includes a catheter (102) defining a central longitudinal axis; and a neuromodulation assembly at a distal portion of the catheter, wherein the neuromodulation assembly includes one or more fluid-delivery needles (120) configured to extend radially outward from the central longitudinal axis at a distal portion of the catheter; and a radially expandable support frame (124) positioned both proximal and distal to the one or more fluid-delivery needles, the radially expandable support frame configured to contact a vessel wall of a vessel (118) of a patient to approximately radially center the distal portion of the catheter within the vessel and to distribute an applied pressure between the neuromodulation assembly and the vessel wall.

A delivery probe for delivering a therapeutic agent to tissue is described including at least one delivery capsule for accommodating the agent, at least one delivery device in fluid communication with the capsule, an actuation mechanism for moving the capsule between an activated position and an inactivated position by providing at least one of a fluid and a vacuum, and a delivery mechanism for forcing the agent out of the capsule. A method of delivering a therapeutic agent to tissue is also described including providing a catheter with a delivery probe at a distal end, positioning the delivery probe next to the tissue, supplying fluid to an actuation chamber to position the probe into an activated position, supplying fluid to a delivery chamber to force the agent out of the probe, and establishing a vacuum in the actuation chamber to position the probe into an inactivated position.