Devices for assisting with the functioning of a tricuspid valve of a heart include a shaft, a flow optimizer, and an anchoring mechanism. A tilting mechanism can be configured to tilt the shaft relative to a central axis of the anchoring mechanism. Leaflets (e.g., multi-layer leaflets) of the flow optimizer can include a membrane and a rim, and the rim can have a higher stiffness than the membrane. A delivery system can be configured to deliver the device and adjust the position of the flow optimizer with respect to the anchoring mechanism.

Disclosed herein are methods to restore myocardial conduction via the injection of conductive nanoparticles into the myocardium via an endovascular injection catheter.

Exemplary embodiments of the present disclosure can include for example, an apparatus, which can include a manipulating arrangement configured to cause a medical device to move, where a portion of the manipulating arrangement can be partly composed of a non-magnetic material, and a computer arrangement in a communication with the manipulating arrangement, and configured to remotely operate the manipulating arrangement. The computer arrangement can include a computer. The communication can be a wired or wireless communication. The medical device can include (i) a catheter, (ii) an endoscope, or (iii) a needle. The manipulating arrangement can include a catheter as the medical device that can be attached to a manipulator.

A medical device including a handle body having a proximal end and a distal end, a spool on the handle body and to move between the distal end and the proximal end of the handle body, a catheter extending from the distal end of the handle body, an actuator attached to the spool and extending through the catheter, such that the actuator is removably connected to one or more dispensable devices at a distal end of the catheter, a spool controller to prevent connection with another of the dispensable devices to the actuator after a predetermined number of dispensable devices have been dispensed by the medical device.

An active return curve deflectable catheter includes an elongate member, a fixation member, a deflection assembly, and a pull wire. The fixation member is coupled to a distal portion of the elongate member. The deflection assembly includes a hub assembly coupled to a proximal end of the elongate member, a handle, and a control member. The pull wire extends from the control member through the hub assembly to the fixation member. The elongate member is configured to deflect from an initial configuration to a deflected configuration in response to a pull force applied to the pull wire by actuation of the control member in a first direction.

A deflectable catheter includes an elongate member having a wall defining a longitudinally extending lumen extending from a proximal end to a distal end, a fixation member coupled to an exterior surface of the wall on a distal portion of the elongate member, and a pull wire extending through the wall of the elongate member from the proximal end of the elongate member to the fixation member. The pull wire is coupled to the fixation member and constrained along its length such that the elongate member is configured to deflect from an initial configuration to a deflected configuration in response to a pull force applied to the pull wire and actively return from the deflected configuration to the initial configuration in response to a push force applied to the pull wire.

A sheath, including a sheath body, a handle, and a traction wire. The traction wire includes a first traction wire. The handle includes a first guide rail member and a first slider. The first slider is connected to the first traction wire. A first groove is provided on an outer wall of the first guide rail member along an axial direction. The first groove includes a first bottom and a first side wall. The first slider slides in the first groove along the first side wall so as to drive the first traction wire to move. At least part of the outer wall of the first guide rail member is radially recessed to a central shaft of the first guide rail member to form the first groove.

Described are drainage catheter hub devices which seal the hub from leakage when connected to a catheter. The catheter hub includes a hub body having an aperture with a sealing element mounted therein and a fluid passageway that communicates with the aperture. The fluid passageway and sealing element are configured to receive a tension member. A lever arm attached to the hub body is operable to secure the position of the tension member in the sealing element in a locked position or allow movement of the tension member through the sealing element in an unlocked position. The lever arm is configured to engage and compress the sealing element to block fluid flow through the sealing element and the aperture when the lever arm is in any position. The hub body may include a centering tab to align the tension member along a longitudinal axis of the hub body.

An expandable introducer sheath provided with a steering mechanism is disclosed. The introducer sheath is configured for providing a prosthesis delivery system percutaneous access to a patient's vasculature. The introducer sheath includes a sheath component defining a central lumen and having a longitudinally-extending, radially-expandable portion. The sheath component also includes a steering wire slidably disposed within a wall thereof that longitudinally extends along the radially-expandable portion. When the steering wire is in a slackened configuration, the steering wire permits a width of the radially-expandable portion to increase. When the steering wire is in a taut configuration, the steering wire permits a distal portion of the sheath component to be manipulated or bent in order to align a distal port of the introducer sheath, for instance, with an ostium of a branch vessel.

The present disclosure provides a medical device comprising an actuator restraining assembly configured to assist in restraining a catheter shaft in a deflected configuration. The actuator restraining assembly may include a brake element, a release element, a connecting sheath, and a connecting rod disposed in a catheter handle, wherein the connecting sheath and connecting rod are attached to an actuator mechanism, and wherein the at brake element is attached to the connecting sheath and the release element is attached to the connecting rod. The brake element is sized and configured to contact an inner wall of the handle to thereby provide resistance to movement of actuator mechanism in a proximal direction with respect to the handle. In one embodiment, the actuator restraining assembly is configured to allow for temporary, i.e., reversible, restraining of the catheter shaft in the deflected configuration.