A drug eluting guide wire comprises a body aperture having low friction characteristics. The guide wire includes an effective leading end segment that is formed along its outer surface with a rapid action body aperture drug eluting agent serving as a vasilodating substance. The low friction characteristics are achieved by the leading end segment of the wire being covered with a low friction lubricating substance such as hydrogel that is loaded with a drug eluting substance in the form of isoprenaline in constituting the segment. Isoprenaline serves a constricted body aperture rapid action relaxing function in amongst others, or at least the case of the guide wire, is used to access a kidney along a ureter in response to temporarily paralyzing the smooth muscles of the ureteric wall resulting in widening of the lumen of the ureter.

A deflectable catheter includes an elongate member having a wall defining a longitudinally extending lumen extending from a proximal end to a distal end, a fixation member coupled to an exterior surface of the wall on a distal portion of the elongate member, and a pull wire extending through the wall of the elongate member from the proximal end of the elongate member to the fixation member. The pull wire is coupled to the fixation member and constrained along its length such that the elongate member is configured to deflect from an initial configuration to a deflected configuration in response to a pull force applied to the pull wire and actively return from the deflected configuration to the initial configuration in response to a push force applied to the pull wire.

An intravenous catheter device may include a guidewire for actively repositioning the catheter tip. A guidewire assembly may be configured to enable a clinician to actively reposition the catheter tip by moving proximal ends of segments of the guidewire. By repositioning the catheter tip, the guidewire assembly may facilitate the collection of a blood sample or the injection of a fluid through the catheter even in instances when the catheter tip has become occluded.

A delivery device to deliver a guidewire through an intravenous catheter assembly may include a housing, which may include a distal end, a proximal end, and a slot. The delivery device may include a guidewire, which may include a proximal end and a distal end. The delivery device may include a guidewire hub disposed within the housing. The guidewire may be secured to the guidewire hub, and the guidewire hub may be configured to move along the slot to advance the guidewire in a distal direction. The distal end of the guidewire may include a fluid permeable structure. For example, the fluid permeable structure may include an elongated core and a coil extending around the elongated core. In some embodiments, a space between the elongated core and the coil may be configured to receive blood in response to the guidewire being inserted into the vasculature.

The present invention relates to a delivery guidewire and a therapeutic treatment device including the delivery guidewire. The delivery guidewire includes a core shaft and a driving member arranged on the core shaft, and the driving member includes inner and outer components. The inner component is made of a metal and fixedly sleeved over the core shaft, and the outer component is made of a polymeric material and fixedly sleeved over the inner component. The inner component fixedly sleeved over the core shaft indirectly enhances attachment of the outer component to the core shaft, thus reducing the risk of loosening, wrinkling or displacement of the outer component and resulting in improved safety and reliability of the delivery guidewire during use.

A delivery guidewire for navigating a catheter in the heart to deliver a valve prosthesis. The delivery guidewire comprising an elongated core, an outer sleeve disposed on the elongated core, and a coil disposed on a distal portion of the elongated core. The delivery guidewire having a first section having a generally uniform diameter and a second section having a tapering section. A distal portion of the second section of the delivery guidewire comprises a pigtail shape atraumatic tip which can remain in the left ventricle.

Devices, systems and methods for treating diseases and disorders effecting the cardiovascular system of the human body are disclosed. An exemplary device in accordance with this disclosure comprises a shaft, tip member fixed to the shaft, and a probe extending beyond a distal surface of the tip member. In some useful embodiments, the tip member is relatively atraumatic and the probe is shaped so as to be more likely to produce trauma than the tip member.

A catheter includes a hollow shaft, a multi-thread coil body covering the hollow shaft, and a cover member covering the multi-thread coil body. The multi-thread coil body includes a ring-shaped or substantially hollow cylindrical joint part in which distal ends of a plurality of element wires are joined in a circumferential direction, a coil main body located at a proximal side of the joint part in an axial direction, in which an outer shape of a cross section of each of the plurality of element wires is circular, and a transition part located between the joint part and the coil main body, in which a width of at least one of the plurality of element wires widens toward a distal end of the element wire.

In various examples, a guidewire with tactile feel is described. The guidewire includes an elongate core wire including a distal end, a proximal end, and a longitudinal axis extending along a length of the core wire from the distal end to the proximal end. A grip portion is disposed on the core wire. The grip portion is configured to provide tactile feel to a user of the guidewire. In some examples, a method for making the guidewire is also described.

A guide wire of the present disclosure includes a core shaft having a distal end portion decreasing in cross-sectional area, a coil body wound to cover the distal end portion, and a distal end fixing portion fixing the core shaft and the coil body to each other. The distal end portion includes a small cross-sectional area portion, a large cross-sectional area portion, and a tapered portion between the small cross-sectional area portion and the large cross-sectional area portion. The core shaft and the coil body are fixed at a portion excluding the tapered portion. A first bending rigidity FR1 of the large cross-sectional area portion, a second bending rigidity FR2 of the small cross-sectional area portion, and a length L of the tapered portion satisfy the following expressions (1) and (2). In the following expressions (1) and (2), the unit of L is mm (millimeter).

(FR1/FR2).sup.0.25/L≥0.83   (1)

1≤L≤3   (2)