A guidewire for use in penetrating through complex and stenosed lesions. The distal tip of the guidewire has a roughened surface to increase frictional engagement with calcified and fibrous tissue to increase the penetration of the distal tip and the guidewire into and through the lesion and reduce the likelihood of deflection of the guidewire tip. The average surface roughness of the distal tip is in the range from 1 micron to 200 microns.

A rotation transmission structure includes a coil body formed by winding wires, and a reinforcing body for connecting adjacent wires of the coil body. When the wires of the coil body are connected to one another by the reinforcing body, the rigidity of a predetermined region of the rotation transmission structure in the longitudinal direction is lower than the rigidity of another region of the rotation transmission structure.

To provide a guide wire including a core shaft having an elongated outer shape, and a coating film on an outer surface of the core shaft, the coating film containing a resin. The coating film includes a marker portion containing a pigment on an outer surface of the coating film and a resin portion not containing the pigment. On the outer surface of the coating film, the marker portion and the resin portion are alternately visible in a stretching direction. Of the coating film, a thickness of a portion where the marker portion is visible on the outer surface and a thickness of a portion where the resin portion is visible on the outer surface are substantially the same, or the thickness of the portion where the marker portion is visible is smaller than the thickness of the portion where the resin portion is visible.

A guide wire includes a main body portion having an elongated outer shape and having a base and a marker alternately presented on an outer surface along an extending direction, and a resin layer having light permeability, covering the outer surface of the main body portion, and including a recessed portion and a protruding portion alternately arranged along the extending direction of the main body portion, wherein in longitudinal cross-section along the extending direction of the main body portion, a width of the marker is wider than a width of the protruding portion.

An access guidewire has a distal portion including a distal portion length and a distal portion diameter. The guidewire also includes an intermediate portion, proximal to the distal portion, having an intermediate portion length and an intermediate portion diameter. A proximal portion is proximal of the intermediate portion and includes a proximal portion length and a proximal portion diameter. The intermediate portion diameter is greater than the the distal portion diameter and the proximal portion diameter.

A catheter and guide wire assembly for measurement of blood pressure in a living body, including a tubular shaft, which is connected to a tubular extension, which is connected to a permeable helical coil, which has a distal end that is secured in a distal tip, and a core member, which is attached in a distal portion of the tubular shaft and extends through the tubular extension and the helical coil, and is secured in the distal tip. The catheter and guide wire assembly has an outer diameter of about 0.35 mm and an open, inner lumen, which includes the tubular shaft, the tubular extension, the helical coil, and the core member. The catheter and guide wire assembly has a total flow-resistance index less than about 1.2×10.sup.6 mm.sup.−3, and more preferably less than about 1.0×10.sup.6 mm.sup.−3, and even more preferably less than about 0.7×10.sup.6 mm.sup.−3.

A guide wire for minimally invasive operations with a distal wire end piece (3, II) connected to a wire main piece (2), wherein the guide wire (I, 10) has, at least in the distal wire end piece (3, II), an inner shaft (4, 14) and at least one protective layer enclosing the inner shaft (4, 14), the inner shaft (4, 14) comprises a first fibre composite material and, at least in the distal wire end piece (3, II), the inner shaft (4, 14) has a plurality of weakened points (8, 18), which are created by mechanical interventions, is characterised in that the weakened points (8, 18) are created by buckling load, bending load and/or breaking load. Correspondingly, for a method for producing a guide wire of this kind it is proposed that the weakened points (8, 18) are created by buckling load, bending load and/or breaking load.

A delivery device to deliver a guidewire through an intravenous catheter assembly may include a housing, which may include a distal end, a proximal end, and a slot. The delivery device may include a guidewire, which may include a proximal end and a distal end. The delivery device may include a guidewire hub disposed within the housing. The guidewire may be secured to the guidewire hub, and the guidewire hub may be configured to move along the slot to advance the guidewire in a distal direction. The distal end of the guidewire may include a fluid permeable structure. For example, the fluid permeable structure may include an elongated core and a coil extending around the elongated core. In some embodiments, a space between the elongated core and the coil may be configured to receive blood in response to the guidewire being inserted into the vasculature.

A guide wire includes a shaft body having a specific portion containing a radiopaque material; and a distal helical body formed into a spiral shape, which contains a radiopaque material and has at least a part located on a more distal end side relative to the shaft body. The guide wire includes a first radiopaque portion as a part of the guide wire in a longitudinal direction of the guide wire, which includes at least a part of the distal helical body. The guide wire further includes a second radiopaque portion as another part of the guide wire in the longitudinal direction of the guide wire, which is located on a more proximal end side relative to the first radiopaque portion, includes at least a part of the specific portion of the shaft body, and has a radiopacity different from that of the first radiopaque portion.

One embodiment of the present disclosure is directed to a selectively connectable medical device. The medical device may include a first flexible wire having an orifice on a distal end thereof and a flexible sleeve surrounding the first flexible wire. The flexible sleeve may be movable along the first flexible wire to a first orientation exposing the orifice, and a second orientation extending over the orifice. The device may further include a second flexible wire having a graspable region on an end thereof. The flexible sleeve may be configured, when the graspable region is threaded through the orifice, to be moved to the second orientation causing the graspable region to bend about an edge of the orifice, and to simultaneously cover the orifice and at least a portion of the graspable region, thereby locking the second wire to the first wire.