A percutaneous catheter for blood removal includes a catheter tube extending in an axial direction with a plurality of distal side holes provided on a distal end part of the catheter tube and communicating a lumen of the catheter with an outside of the catheter tube. The plurality of distal side holes is spirally arranged in the axial direction of the catheter tube, and at least one distal side hole at the proximal end side of the spirally arranged side holes is formed to have a diameter smaller than a diameter of a distal side hole at the distal end side of the spirally arranged side holes.

A percutaneous catheter for blood removal includes a catheter tube extending in an axial direction with a plurality of distal side holes provided on a distal end part of the catheter tube and communicating a lumen of the catheter with an outside of the catheter tube. The plurality of distal side holes is spirally arranged in the axial direction of the catheter tube, and at least one distal side hole at the proximal end side of the spirally arranged side holes is formed to have a diameter smaller than a diameter of a distal side hole at the distal end side of the spirally arranged side holes.

A catheter system insertable into a living body to convey blood has a catheter tube and a stylet. The catheter tube has an expansion portion, a shaft portion, and a lumen. The stylet includes an outer peripheral member that extends in an axial direction and has an outer diameter the same as an inner diameter of the shaft portion, an inner peripheral member provided with an exposed portion exposed from a distal end of the outer peripheral member and provided on an inner periphery of the outer peripheral member so as to be slidable with respect to the outer peripheral member, and a fitting stopper into which a fitting member on an outer periphery of a proximal end of the outer peripheral member is fittable. A region is formed in the fitting stopper in which the outer peripheral member and the fitting member are movable.

A catheter system insertable into a living body to convey blood has a catheter tube and a stylet. The catheter tube has an expansion portion, a shaft portion, and a lumen. The stylet includes an outer peripheral member that extends in an axial direction and has an outer diameter the same as an inner diameter of the shaft portion, an inner peripheral member provided with an exposed portion exposed from a distal end of the outer peripheral member and provided on an inner periphery of the outer peripheral member so as to be slidable with respect to the outer peripheral member, and a fitting stopper into which a fitting member on an outer periphery of a proximal end of the outer peripheral member is fittable. A region is formed in the fitting stopper in which the outer peripheral member and the fitting member are movable.

An integrated flow source is a limiting factor in numerous microfluidic applications. In addition to precise gradients and controlling molecular transports, a built-in source of stable and accurate flow can enable novel shear stress modulations for long-term cell culturing studies. The Tesla turbine, when used as a pump on the microfluidic regime, produces stable and accurate fluid gradients by utilizing laminar flow between its rotating discs Utilizing a stereolithography based 3D printer, a tesla pump (Ø10 cm) and associated housing capable of driving a microfluidic gradient is provided having a printed rotor surface topology of the pump in order to enhance pumping of biological fluids like blood at elevated viscosities. The surface topology is tuned via 3D pixilation, and this modulation completely recovered the pressure loss between pumping water at 1 cP versus glycerol solution at 3 cP. As a result, increased fluid viscosities, and even Non-Newtonian viscosities, can be used.

An integrated flow source is a limiting factor in numerous microfluidic applications. In addition to precise gradients and controlling molecular transports, a built-in source of stable and accurate flow can enable novel shear stress modulations for long-term cell culturing studies. The Tesla turbine, when used as a pump on the microfluidic regime, produces stable and accurate fluid gradients by utilizing laminar flow between its rotating discs Utilizing a stereolithography based 3D printer, a tesla pump (Ø10 cm) and associated housing capable of driving a microfluidic gradient is provided having a printed rotor surface topology of the pump in order to enhance pumping of biological fluids like blood at elevated viscosities. The surface topology is tuned via 3D pixilation, and this modulation completely recovered the pressure loss between pumping water at 1 cP versus glycerol solution at 3 cP. As a result, increased fluid viscosities, and even Non-Newtonian viscosities, can be used.

A catheter for percutaneous cardiopulmonary support has a lumen through which blood flows to a living body. The catheter comprises a catheter tube including a tubular reinforcing body including a plurality of wires braided into a mesh shape and a resin layer provided so as to cover the reinforcing body. A plurality of side holes are formed at a distal end of the catheter tube to communicate the lumen with the outside of the catheter tube. The side holes allow the blood flowing through the lumen to flow out in a direction intersecting an axial direction of the catheter tube when the catheter tube is indwelled. The plurality of side holes preferably may be spirally arranged in a circumferential direction of the tube.

A catheter for percutaneous cardiopulmonary support has a lumen through which blood flows to a living body. The catheter comprises a catheter tube including a tubular reinforcing body including a plurality of wires braided into a mesh shape and a resin layer provided so as to cover the reinforcing body. A plurality of side holes are formed at a distal end of the catheter tube to communicate the lumen with the outside of the catheter tube. The side holes allow the blood flowing through the lumen to flow out in a direction intersecting an axial direction of the catheter tube when the catheter tube is indwelled. The plurality of side holes preferably may be spirally arranged in a circumferential direction of the tube.

A cardiopulmonary bypass system is described that includes a cardiopulmonary bypass machine having a console, the console has a base and a frame connected to the base. The system further comprises a plurality of peripheral modules operatively connectable to the cardiopulmonary bypass machine via one or more cables. The system further comprises a cable chase having a first end and a second end, and a housing that extends at least partially between the first end and second end to at least partially enclose a channel for receiving one or more cables or conduits connected to one or more of the peripheral modules.

Systems and methods for evaluating blood behavior when flowing through an implantable medical device are provided. A flow loop includes the implantable medical device, and a blood reservoir configured to contain a volume of blood and to supply blood from the volume of blood to the implantable medical device. The flow loop further includes a plurality of tubing sections coupled in flow communication between the implantable medical device and the blood reservoir, the plurality of tubing sections including a least a first tubing section having a first diameter and a second tubing section having a second diameter, wherein the second diameter is smaller than the first diameter, and a flow diverter coupled in flow communication between the plurality of tubing sections and the blood reservoir, the flow diverter comprising an outlet that is configured to be positioned below a surface of the volume of blood.