A method for performing a medical procedure in an intestine of a patient is provided. The method comprises providing a system comprising: a catheter for insertion into the intestine, the catheter comprising: an elongate shaft comprising a distal portion; and a functional assembly positioned on the shaft distal portion and comprising at least one treatment element. The catheter is introduced into the patient, and target tissue is treated with the at least one treatment element. The target tissue comprises mucosal tissue of the small intestine, and the medical procedure can be configured to treat at least one of non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH).

A method includes using a subcutaneously-implanted pump to deliver to a portion of a gastrointestinal tract a formulation including a levodopa compound and a carbidopa compound which provides a treatment for a neurological disease, such as Parkinson’s disease.

Various embodiments disclosed relate to drug-coated balloon catheters for treating strictures in body lumens and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent.

The present disclosure provides endoscopic retrograde cholangiopancreatography (ERCP) catheter systems having multiple ports and sensors configured to determine the location of the catheter's and/or guidewire's distal end as well as optional one or more magnetic bending aids, configured to aim a guidewire to the desired duct location. Further provided is a guidewire having a magnetic end and optional sensing elements. Also provided are methods of using the catheters and/or guidewires in ERCP procedures.

A method for performing a medical procedure in an intestine of a patient is provided. The method comprises providing a system comprising: a catheter for insertion into the intestine, the catheter comprising: an elongate shaft comprising a distal portion; and a functional assembly positioned on the shaft distal portion and comprising at least one treatment element. The catheter is introduced into the patient, and target tissue is treated with the at least one treatment element. The target tissue comprises mucosal tissue of the small intestine, and the medical procedure can be configured to treat polycystic ovarian syndrome (PCOS).

Various embodiments disclosed relate to drug-coated balloon catheters for treating strictures in body lumens and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent.

The present invention relates to a system for bypassing stomach and creating a barrier for the proximal small bowel to include duodenum and jejunum so that food delivered is directly in the jejunum that results in weight loss. The technique involves placement and fixation of a gastric bypass device within the stomach to cover the small bowel. The present invention also provides a device and method which enables the suturing of the gastric bypass device. The duodeno-jejunal barrier remains unchanged and helps in bypassing the absorptive surface of the proximal small bowel.

Provided herein are anti-inflammatory peptide amphiphiles (AIF-PAs) and methods of use thereof. In particular, nanofiber of AIF-PAs are provided and methods of use thereof in the treatment of inflammatory bowel diseases (e.g., Crohn's disease).

Various embodiments disclosed relate to drug-coated balloon catheters for treating strictures in body lumens and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent.

A guide wire holder includes a sheath having a lumen, an operation wire which is inserted through the lumen to be able to advance and retract, and a hook which is continuous with a distal end of the operation wire and protrudes from a distal end of the sheath, wherein the sheath has an inner wall surface which forms a groove configured to extend from the distal end of the sheath to a proximal end side of the sheath, the groove has an opening portion which opens to an outer peripheral surface of the sheath, the hook has a guide wire engagement surface which is engageable with a guide wire, and the guide wire is able to be held between the guide wire engagement surface and the inner wall surface.