Various embodiments disclosed relate to drug-coated balloon catheters for treating, preventing, or reducing the recurrence of a stricture and/or cancer, or for treating benign prostatic hyperplasia (BPH), in a non-vascular body lumen and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent. In some embodiments, the balloon catheter includes a length-control mechanism which stretches and elongates the balloon when it is in a deflated state, giving the balloon a smaller cross-sectional deflated profile for tracking through the body lumen and for removal after treatment.

The device, that can be implanted in the intestinal cavity, comprises a reactor comprising a semi-permeable or porous membrane or coating linked to a element for attachment to an intestinal or gastric wall. The reactor can be in the form of a ribbon, a structure having more than two faces or an open structure delimiting a lumen, comprising, or formed from, a semi-permeable or porous membrane. The reactor can also delimit, at least partially with the semi-permeable or porous membrane of same, a closed inner space. The reactor can comprise or carry enzymes or micro-organisms, in particular bacteria or yeast. The reactor is used for generating a chemical reaction with one or more molecules present in the intestine, or for producing one or more biologically active molecules. It can, in particular, be used for consuming sugars, disaccharides and simple sugars or producing essential amino acids or other molecules having a positive effect on the health.

A guide wire holder includes a sheath having a lumen, an operation wire inserted into the lumen and configured to be able to advance and retract in the lumen, and a hook continuous with a distal end of the operation wire, being formed to be bent in a convex shape toward a distal side, and protrudes from a distal end of the sheath. The sheath has a side surface extending from the distal end of the sheath to a proximal end side in a direction of the longitudinal axis. The hook intersects a ridge line of the side surface and forms a closed region closed by the hook and the ridge line in a front view. The guide wire holder is configured to hold the guide wire located outside the sheath in the closed region in a state that the hook is disposed at a retracted position at which the hook is retracted.

Various embodiments disclosed relate to drug-coated balloon catheters for treating strictures in body lumens and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent.

A method for performing a medical procedure in an intestine of a patient is provided. The method comprises providing a system comprising: a catheter for insertion into the intestine, the catheter comprising: an elongate shaft comprising a distal portion; and a functional assembly positioned on the shaft distal portion and comprising at least one treatment element. The catheter is introduced into the patient, and target tissue is treated with the at least one treatment element. The target tissue comprises mucosal tissue of the small intestine, and the medical procedure can be configured to treat at least one of non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH).

The present invention relates to a stent with a pigtail structure used for connection between organs of different kinds where a through hole is formed on each of the organs of different kinds and portions around the through holes are connected to each other, the stent comprising: a stent body where both end parts are arranged across the through holes formed on the organs of different kinds and a connecting passage which connects the two organs of different kinds is formed; and a one-side wound end part and an other-side wound end part which are formed in a pigtail shape at both end parts of the stent body to be caught and fixed to the through holes, such that portions of the organs of different kinds around the through holes are in close contact with each other, wherein the stent body, the one-side wound end part, and the other-side wound end part are provided as an integral body having a mesh structure made of woven wire and comprising a cover film which covers the woven wire for sealing of the connecting passage.

Various embodiments disclosed relate to drug-coated balloon catheters for treating strictures in body lumens and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent.

Various embodiments disclosed relate to drug-coated balloon catheters for treating strictures in body lumens and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent.

Endoluminal devices and methods that facilitate treatment of a desired treatment region of the gastrointestinal tract, in particular the duodenum, are provided herein. Such devices include a catheter having a treatment delivery portion disposed between proximal and distal balloons. The treatment can include thermal ablation of the treatment region by delivering a treatment fluid to the treatment region between the inflated balloons. In one aspect, the treatment fluid is delivered so as to fill the entire treatment region between the balloons without regard to the inflated balloon pressure. To ensure filling, the treatment fluid can be delivered into the treatment region until a pressure increase is observed or until a pre-determined volume is delivered. Other treatment devices and methods include means of uniformly distributing a treatment gas for plasma ablation, electrical ablation energy or a chemical or drug eluting stent.

The present invention provides an automatic drug delivery device. The automatic drug delivery device includes an enclosure and a first piston disposed in the enclosure. The first piston partitions the enclosure to a first drug delivery chamber and a first expansion chamber. A first through hole and a second through hole are formed in the wall of the enclosure, the first through-hole communicates with the first drug delivery chamber, and the second through-hole communicates with the first expansion chamber. A first targeted dissolution membrane covers the first through hole and the second through hole, and dissolves at a first targeted region. A drug is filled in the first drug delivery chamber, and an expandable material is included in the first expansion chamber. The expandable material in the first expansion chamber can expand after absorbing liquid.