An earpiece includes an earbud that supports at least one electrode, and an ear tip that includes a hydrogel. The ear tip is configured to be coupled to the earbud such that the hydrogel overlies the at least one electrode and such that the hydrogel is disposed between the at least one electrode and the user's skin when the earpiece is worn.

A therapeutic electrode component includes a base plate having a first side and a second side having a conductive surface. A repository having an internal volume to releasably retain a conductive fluid is disposed on the first side of the base plate. A rupturable membrane is disposed between the internal volume of the repository and the conductive surface of the base plate. A coupling is disposed on the base plate that is configured to detachably engage a gas charge, whereby the gas charge is detachable from the coupling without causing destruction of the gas charge, to provide a hermetic seal with an outlet of the gas charge, and to provide fluid communication between the internal volume of the repository and the outlet of gas charge when the gas charge is engaged by the coupling. A retainer is configured to detachably secure the gas charge to the base plate.

A method and apparatus for treatment of cancer is provided. The method can include systemic administration of selective A3 adenosine receptor (A3AR) agonists like CI-IB-MECA (CF 101), LI-529, cordycepin or similar drugs in combination with application of pulsed Electric Field Stimulation (EFS) to the treatment area. A3AR agonists may be delivered in blend with allosteric enhancers of A3AR agonists potency like LUF6000 or other similar drugs. EFS is provided in three or more directions, which significantly increases expression of A3ARs on the cellular membranes and allows achieving a downstream apoptotic signal several-fold stronger than the signal created by an agonist alone. The apparatus may be dedicated to one patient usage over long period of time—hours and days continuously or intermittently.

An electromedical adapter, an electromedical electrode and an electromedical pulse generator are provided for the field of medical electrical stimulation. In order to connect a non-coiled electrode portion (3) to a coiled electrode portion (2), in particular the adapter (1) is provided, having at least one contact element (5) which can be contacted by a coiled electrode portion (2) of an electrode (4) in such a way that the coiled electrode portion (2) surrounds, i.e. radially surrounds, a longitudinal axis of the main body (7) of the adapter with the at least one coiled conductor (8) thereof.

Disclosed is an extracorporeal shock wave medical device with high-frequency and low-frequency treatment functions. The extracorporeal shock wave medical device includes a body portion, a cylinder disposed inside the body portion, a moving portion which linearly moves inside the cylinder, a connecting portion disposed at the end of the cylinder and connected to the body portion to selectively collide with the moving portion when the moving portion moves, an impact portion connected to the connecting portion and configured to transmit an impact to the outside when the moving portion collides with the connecting portion, and a waveform transmitting portion electrically connected to the impact portion to transmit a high frequency or low frequency to the impact portion.

The present invention provides a thin and flexible device and method of use thereof for wound treatment and infection control. The integrated surface stimulation device may comprise wireless stimulation system in a disposable and/or reusable flexible device for widespread use in multiple therapeutic applications. The invention would be situated on the skin surface of a patient and would be activated so as to reduce the overall occurrence of infections and/or increase wound healing rates. As provided, the device will comprise an integrated power supply and pre-programmable stimulator/control system on a flexible polymeric substrate layer with areas of stimulating electrodes, applied using techniques such as those found in additive manufacturing processes. The device is especially valuable in treating biofilm-based infections.

The present disclosure is directed to a system and method modulating targeted neural and non-neural tissue of a nervous system for the treatment of head-and-face pain. Electrical stimulation is delivered transcutaneously to the treatment site that modulates the targeted neural- and non-neural tissue of the nervous structure, inhibiting nervous signaling and the perception of pain.

A therapeutic electrode component includes a base plate having a first side and a second side having a conductive surface. A repository having an internal volume to releasably retain a conductive fluid is disposed on the first side of the base plate. A rupturable membrane is disposed between the internal volume of the repository and the conductive surface of the base plate. A coupling is disposed on the base plate that is configured to detachably engage a gas charge, whereby the gas charge is detachable from the coupling without causing destruction of the gas charge, to provide a hermetic seal with an outlet of the gas charge, and to provide fluid communication between the internal volume of the repository and the outlet of gas charge when the gas charge is engaged by the coupling. A retainer is configured to detachably secure the gas charge to the base plate.

A planar flexible electrode arrangement for a dielectric barrier plasma discharge has a central region (107) and an edge region (108) and at least one planar electrode (102) to which a high-voltage potential can be applied and which is embedded in a planar dielectric (101) that forms an upper face (103) and a contact face (104), wherein the planar dielectric (101), at least in the edge region (108), has the shape of a spiral-shaped wound-up strip (109) and the at least one electrode (102) is formed by at least one electrical conductor (114) that extends in the longitudinal direction of the wound-up strip (109) and that opens into an end face of the strip (109), which conductor (114) is surrounded, with the sole exception of the end face of the strip (109), by the dielectric of the strip (109) and, in the region of the end face of the strip (109), is electrically insulated from the surroundings by a cover element (116). The electrode arrangement can be adapted easily, and without tools, in its bearing surface to the size of the area of a surface that is to be treated, by virtue of the fact that material recesses (111) are present across the width of the strip (109), and that the material of the dielectric (101) and of the at least one conductor (114) is chosen such that the strip (109), together with the at least one conductor (114), can be torn off across its width along the material recesses (111).

Methods, systems and apparatuses for delivering electrical or other therapy in the vicinity of the eye, comprising eyepieces having a plurality of electrodes that are placed on the eyelid. Some examples are just eyepieces having a periphery that partly surrounds the eye, other examples fully surround the eye or include a temporal portion configured to extend to the temple of the user. Some examples also include a field that covers the eye to take the form of a goggle. Numerous configurations for power supply and therapy output are discussed.