Apparatuses and methods are disclosed for efficient wireless powering of an electrical load with precise external control over pulsed voltage waveform and metering of charge delivered. The system interfaces to an inductive coil for RF power delivery from an external duty-cycled RF power transmitter, and the electrical load. The electrical load may be a photosensitive array of electrodes for an optically addressed, electrically activated retinal prosthesis. The voltage waveform to activate the load is controlled by the transmitted RF amplitude, including switching between cathodic and anodic phases of electrical stimulation. Charge delivered to the load is quantified as discharge events through a series capacitor, transmitted by backtelemetry to the receiver for continuous monitoring throughout the stimulation phases. The subject disclosure further provides for calibration of voltage amplitude and charge metering, to compensate for variable wireless link and load conditions, through additional stimulation phases with a supplementary load with known and stable characteristics.

An example of a system for programming neurostimulation according to a stimulation configuration may include stimulation configuration circuitry, volume definition circuitry, stimulation effect circuitry, and recording circuitry. The stimulation configuration circuitry may be configured to determine the stimulation configuration. The volume definition circuitry may be configured to determine stimulation field model(s) (SFM(s)) each representing a volume of tissue activated by the neurostimulation. The stimulation effect circuitry may be configured to determine a stimulation effect type for each tagging point specified for the SFM(s) and to tag the SFM(s) at each tagging point with the stimulation effect type determined for that tagging point. The stimulation effect type for each tagging point is a type of stimulation resulting from the neurostimulation as measured at that tagging point. The recording circuitry may be configured to generate SFM data representing the determined SFM(s) with the stimulation effect type tagged at each tagging point.

A data transfer apparatus (“DTA”) connects to the field generator in a TTFields therapy system using the same connector on the field generator that is used to connect a transducer interface to the field generator. The field generator automatically determines whether the transducer interface or the DTA is connected to it. When the transducer interface is connected to the field generator, the field generator operates to deliver TTFields therapy to a patient. On the other hand, when the DTA is connected to the field generator, the field generator transfers patient-treatment data to the DTA, and the DTA accepts the data from the field generator. After the field generator and the DTA have been disconnected, the DTA transmits the data to a remote server, e.g., via the Internet or via cellular data transmission.

An implantable medical device (IMD) and method are provided. The IMD includes a sensing channel configured to obtain biological signals indicative of biological behavior of an anatomy of interest over a period of time. The biological behavior has a feature of interest that repeats over time. The biological signals have clinically relevant (CR) segments that include information related to the feature of interest. The biological signals have non-clinically relevant (NCR) segments that do not include information related to the feature of interest. At least one of circuitry or a processor are configured to compare the biological signals to an amplitude window to distinguish the CR segments from the NCR segments, save to memory the CR segments and delete the NCR segments, save to memory time information indicative of a duration of the NCR segments that were deleted and to form a lossy compressed data set for the biological signals.

A method of treating a subject includes providing a mobile telecommunications device including a processor, a transceiver coupled to the processor including a transmitter for generating pulsed electrical signals adapted to be coupled to an antenna, at least one memory device accessible by the processor. The mobile telecommunications device is positioned proximate to the subject. Pulsed electrical signals are begun to be generated to cause the transmitter to drive the antenna, wherein the antenna in response to the pulsed electrical signals emits a pulsed electromagnetic field (PEMF) that reaches the subject to provide treatment.

An implanted stimulator can deliver a patient-detectable electrical stimulation to remind or prompt a patient to interact with an implanted therapeutic device (e.g., neurostimulator) when a prompting event occurs. For example, the apparatuses and methods described herein may be configured to apply a prompting patient-detectable electrical vagus nerve stimulation to remind a patient that it is time to administer a therapeutic dose. When the therapeutic device is operated in an automatic fashion, the apparatus can also deliver a patient-detectable warning stimulation prior to the therapeutic stimulation to let the patient know that a therapeutic stimulation will be delivered soon thereafter.

Systems and methods for active charge-balancing for high frequency neural stimulation are disclosed. One illustrative method described herein includes: applying, through a pair of electrodes electrically coupled to a bundle of nerve fibers during a stimulation phase of a neural stimulation procedure, a first current to the bundle of nerve fibers; applying, through the pair of electrodes during a recovery phase of the neural stimulation procedure, a second current to the bundle of nerve fibers, the first current and the second current having opposite polarities; determining sampled voltages between the pair of electrodes during the stimulation phase, during the recovery phase, or between the stimulation phase and the recovery phase; determining a charge buildup in the bundle of nerve fibers based on the sampled voltages; applying, through the pair of electrodes during the stimulation phase or during the recovery phase, a delta current to the bundle of nerves based on the sampled voltages to minimize the charge build up.

A controller-transmitter transmits acoustic energy through the body to an implanted acoustic receiver-stimulator. The receiver-stimulator converts the acoustic energy into electrical energy and delivers the electrical energy to tissue using an electrode assembly. The receiver-stimulator limits the output voltage delivered to the tissue to a predetermined maximum output voltage. In the presence of interfering acoustic energy sources output voltages are thereby limited prior to being delivered to the tissue.

A controller-transmitter transmits acoustic energy through the body to an implanted acoustic receiver-stimulator. The receiver-stimulator converts the acoustic energy into electrical energy and delivers the electrical energy to tissue using an electrode assembly. The receiver-stimulator limits the output voltage delivered to the tissue to a predetermined maximum output voltage. In the presence of interfering acoustic energy sources output voltages are thereby limited prior to being delivered to the tissue.

Disclosed are methods and medical device systems for automated delivery of therapies for pain and determination of need for and safety of treatment. In one embodiment, such a medical device system may comprise a sensor configured to sense at least one body signal from a patient; and a medical device configured to receive a first sensed body signal from the sensor; determine a patient pain index based at least in part on said first sensed body signal; determine whether said patient pain index is above at least a first pain index threshold; determine a safety index based at least in part on a second sensed body signal; select a pain treatment regimen based on at least one of said safety index and or a determination that said pain index is above said first pain index threshold; and deliver said pain treatment regimen.