The invention discloses an electrochemical device for treating cancer, characterized by using an acupuncture needle as a working electrode to produce hydrogen in a tumor tissue, thereby destroying the tumor tissue through the produced hydrogen gas. The device of the invention has low cost and simple operation, can realize minimally invasive treatment, and is green and environmentally friendly.

A current stimulation device and an osteoblast differentiation treatment system through current stimulation are provided, which relate to the technical field of bioengineering. The current stimulation device includes a nanogenerator, which is electrically connected to a stimulation electrode. The stimulation electrode makes contact with an affected part. The stimulation of the present disclosure is applied to the affected part of a fracture patient, and realizes the current stimulation through the nanogenerator, promotes proliferation and activity of the osteoblast. The present disclosure provides a new idea for fracture healing, and promotes application progress of the nanogenerator in a wearable electronic medical instrument. The present disclosure has portability and an excellent clinical application prospect.

Embodiments of medical treatment including skin treatment using electrical energy, especially with the primary purpose for skin treatment for aesthetics are described generally herein. Other embodiments may be described and claimed.

A trial stimulation system includes a disposable trial electrical stimulator that, in some examples, is sterilized for a single use in a stimulation trial of one patient. Additionally, systems for securing a disposable trial stimulator to the body of a patient are described, which may function to improve the durability of the system during the trial period and reduce the risk of damage or malfunction to the system due to lead/electrode dislocation and/or off-label uses like showering or bathing with the trial stimulator still secured to the body.

An auricular nerve field stimulation device may include first non-percutaneous electrodes arranged to contact a ventral aspect of an auricle, second non-percutaneous electrodes arranged to contact a dorsal aspect of the auricle, and electrical circuitry coupled to the electrodes and configured to selectively apply electrical stimulation signals to the electrodes to cause a first set of trans-auricular currents to flow through the auricle between the first electrodes and respective ones of the second electrodes paired therewith according to a first pairing, and to cause a second set of trans-auricular currents to flow through the auricle between the first electrodes and respective ones of the second electrodes paired therewith according to a second pairing different from the first pairing, the first and second sets of trans-auricular currents to stimulate at least one auricular nerve field within the auricle.

A pulse generating device for delivery of electrical pulses to a desired tissue and configured to be connected to needle electrodes arranged at the desired tissue. The device comprises a determining module configured to determine a primary voltage amplitude of a first pulse and a number of consecutive pulses to be generated. Further, the device comprises a pulse generator configured to generate one or more of the determined number of consecutive pulses such that the generated first pulse has the primary voltage amplitude and that the generated consecutive pulses have a respective voltage amplitude consecutively decreasing between consecutive pulses, whereby an increase in a current value of the generated consecutive pulses above a threshold value is avoided. Furthermore, the device comprises a terminating module configured to terminate generation of the one or more pulses when a value of a total absorbed energy exceeds a threshold value.

An introducing device for locating a tissue region and deploying an electrode is shown and described. The introducing device may include an outer sheath. An inner sheath may be disposed within the outer sheath. The inner sheath may be configured to engage an implantable electrode. In an example, the inner sheath may comprise a stimulation probe having an uninsulated portion at or near a distal end of the delivery sheath. The outer sheath may be coupled to a power source or stimulation signal generating circuitry at a proximal end. A clinician may control application of the stimulation signal to a tissue region via the outer sheath.

Methods and apparatus for the reproducible, consistent and efficacious delivery of an HBV vaccine to a subject. The disclosure comprises apparatus for the controlled administration of the HBV vaccine through an orifice to the subject, a plurality of penetrating electrodes arranged with a predetermined spatial relationship relative to the orifice, and an electrical signal generator operatively connected to the electrodes.

Aspects of the disclosure include a bio-electric stimulation probe assembly including a patch including a first aperture and also a guide socket including a grommet and a second aperture. The guide socket is positioned on the patch such that the first and second apertures are aligned. The assembly further includes a guide including a tip that is positioned within and rotatable within the grommet. A probe of the assembly having at least one electrode is interconnected with the guide and extends through the first and second apertures. The guide and guide socket are collectively arranged and configured so that the guide has three degrees of rotational freedom with respect to the grommet thus meaning the probe correspondingly has three degrees of rotational freedom with respect to the grommet. Methods of using stimulation probe assemblies are also disclosed.

A wearable device combines its existing functions (e.g., a headphone) with non-invasive autonomic modulation using tragus or other external auditory meatus stimulation. The wearable device can output audio to a user, such as music, podcast, etc., and further provide modulation of the vagus nerve via tragus stimulation or other external auditory meatus stimulation to treat various diseases.