Pursuant to embodiments of the present invention, a method of performing electronically controlled electrotherapy may include modifying or killing target cells and simultaneously modifying a secondary outcome by delivering electrical pulses and dynamically adjusting an energy delivery profile of the electrical pulses in response to a measurement. The secondary outcome may be a physical outcome, a biological outcome, and/or a systemic outcome.

The present invention provides for the intratumoral delivery of at least one immunostimulatory cytokine in combination with at least one checkpoint inhibitor. In particular, it provides delivery of a plasmid encoding the immunostimulatory cytokine using intratumoral electroporation. The checkpoint inhibitor may be administered systemically or encoded on a plasmid and delivered using intratumoral electroporation. The checkpoint inhibitor may be delivered contemporaneously with or after treatment with the immunomodulatory cytokine.

Various embodiments of a system and method for the treatment of brain cancer using a subdurally-implanted alternating electric field generation apparatus are disclosed herein.

A system for detecting presence of coronavirus in a subject, the system including a first pad for placing a first hand, the pad including a contact to measure conductance of the subject's body, a conductance meter connected to the contact, a second pad for placing a second hand, a source of electromagnetic radiation for irradiating the second pad. A system for detecting presence of coronavirus in a subject, the system including a chip with a plurality of wires disposed on or in the chip, a conductance meter arranged to measure conductance between the wires, and biological material associated with the coronavirus disposed on or in the chip. Related apparatus and methods are also described.

A system and method for delivering TTFields are herein described. The system comprises an electric field generator generating a signal having a frequency from 50 kHz to 500 kHz and coupled to a first lead and a second lead. A first pad is coupled to the first lead and includes a conductive foam and a first conductive gel. The conductive foam receives the signal from the first conductive lead and comprises a solid continuous phase material comprising at least a conductive material. A plurality of pockets is interspersed throughout the conductive foam. The first conductive gel is attached, absorbed, or adsorbed to the conductive foam. The second lead is coupled to the electric field generator and a second pad is coupled to the second lead. The second pad has a second electrode element connected to a second conductive gel element and receives the signal from the second conductive lead.

Transducer arrays for applying alternating electric fields (e.g., tumor treating fields a.k.a. TTFields) to a subject's body typically include a plurality of capacitively coupled electrode elements. Often, certain electrode elements on a given array tend to run hotter than other electrode elements. For example, in many anatomical contexts, the corner elements of the transducer array tend to run hotter than the non-corner elements. The spread of operating temperatures between the electrode elements that tend to run hotter and the other electrode elements can be reduced by wiring a capacitor in series with those electrode elements that tend to run hotter (e.g., the corner elements).

A method of applying electrode elements configured in an array of elements to an individual's skin, the electrode elements being part of an apparatus for delivering a plurality of electromagnetic fields to the body of the individual, the method comprising the steps of: positioning, applying, holding and bowing. The positioning step includes the positioning of each of the electrode elements of the array of elements into corresponding cavities in at least one holding rack. The applying step includes the applying of a medical adhesive to a surface of the plurality of electrode elements. The holding step includes the holding of the holding rack against the skin at a selected location. The bowing step includes the bowing of a portion of the holding rack causing one of the electrode elements to pop out of the holding rack, with the electrode element adhering to the skin by way of the medical adhesive.

Characteristics of alternating electric fields that will be applied to a target region in a subject’s body can be selected by applying different sets of pulses between electrode elements positioned on opposite sides of the target region. Thermal responses to the different sets of pulses are determined. Based on these thermal responses, the system selects a set of characteristics for output pulses of alternating current that will (a) maximize peak current amplitude and (b) keep temperatures at the electrode elements below a threshold value.

Embodiments herein relate to implantable cancer therapy electrodes with reduced magnetic resonance imaging artifacts. In an embodiment, a lead for a cancer treatment system can include a lead body with a proximal end and a distal end and defining a lumen, and one or more electric field generating electrodes, wherein the one or more electric field generating electrodes can be disposed along a length of the lead body. The one or more electric field generating electrodes include a ribbon wire with a thickness of the ribbon wire in a radial direction with respect to the lead body of less than 0.005 inches, or a walled tube with a thickness of the walled tube less than 0.005 inches, or a sputter coating with a thickness of the sputter coating in a radial direction with respect to a lead body of less than 0.005 inches. Other embodiments are also included herein.

The present invention concerns a system for treating cancer or tumors by thermotherapy, comprising an expandable implant device, an excitation catheter and an electric power source, wherein the implant device configured for circumferentially subtending a vessel upon expansion of the implant device in said vessel, the implant device comprising a set of cross-connected conductors forming a circumferential structure with openings in between the conductors, said openings having a minimal opening distance when the implant device is expanded of at least 2 mm, wherein the excitation catheter comprises a longitudinal shaft with a distal end, a proximal end, and a longitudinal body in between, whereby the catheter comprises a longitudinal axis along the longitudinal shaft, and whereby the catheter further comprises an emitter coil at or near the distal end, and whereby the longitudinal body of the catheter further comprises a wiring lumen comprising electrical wiring extending from the distal end to the proximal end, and whereby the electrical wiring is connected at or near the distal end with the emitter coil, and wherein the electric power source is connectable, and preferably connected, to the wiring via the proximal end of the catheter shaft for the generation of a time-varying magnetic field with the emitter coil.