A system and method for delivering TTFields are herein described. The system comprises an electric field generator generating a signal having a frequency from 50 kHz to 1 MHz and coupled to a lead. A pad is coupled to the lead and includes a solid continuous phase material and a conductive gel. The solid continuous phase material receives the signal from the lead, has a skin-facing surface, and is constructed of a conductive material or has a conductive material attached to, absorbed into, or adsorbed onto the solid continuous phase material. Pockets intersect the skin-facing surface, the pockets sized and dimensioned to receive a hair shaft. The conductive gel is attached to, absorbed into, or adsorbed onto the skin-facing surface and positioned within some of the pockets.

Provided herein are methods of treating a patient comprising providing a medical apparatus comprising an external system and an implantable system, implanting the implantable system, and delivering at least one of power or data to the implantable system with the external system. The external system comprises: at least one external antenna configured to transmit a first transmission signal to the implantable system; an external transmitter configured to drive the at least one external antenna; an external power supply; and an external controller. The implantable system comprises: at least one implantable antenna configured to receive the first transmission signal from the first external device; an implantable receiver; at least one implantable functional element configured to interface with the patient; an implantable controller; an implantable energy storage assembly; and an implantable housing surrounding at least the implantable controller and the implantable receiver. Medical apparatus are also provided.

The present invention provides a method of inhibiting the growth of proliferating cells, viruses or bacteria in living tissue, the method comprising: applying low to mid-level frequency Alternating Current electromagnetic signals to the living tissue with a transducer comprising a magnetically conductive material passing through a conduction ring energized by an electrical signal to create the low to mid-level frequency AC current electromagnetic signals within the living tissue; wherein the low to mid-level frequency AC current electromagnetic signals have a frequency in the range of about 50 kHz to about 300 kHz and are produced with an AC voltage generator; and circulating fluid in the living tissue provide a secondary coil for the transmission of the low to mid-level frequency AC current electromagnetic signals.

A quality assurance apparatus for a cancer treatment system with an electric field, comprising: an electric field generator configured to transmit an electric field to an inside of an electromagnetic phantom through an electrode array attached to the electromagnetic phantom; a measurement unit configured to measure any one of a voltage, a current, and an electric field inside the electromagnetic phantom; a data collection unit configured to collect a value measured by the measurement unit and convert the measured value into a digital value; an analysis unit configured to calculate and monitor a distribution and intensity of the electric field inside the electromagnetic phantom through the value transmitted from the data collection unit; and a verification unit configured to verify the electric field monitored by the analysis unit.

Tumor treating fields (TTFields) can be delivered by implanting a plurality of sets of implantable electrode elements within a person's body. Temperature sensors positioned to measure the temperature at the electrode elements are also implanted, along with a circuit that collects temperature measurements from the temperature sensors. In some embodiments, an AC voltage generator configured to apply an AC voltage across the plurality of sets of electrode elements is also implanted within the person's body.

Embodiments herein relate to medical devices and methods for using the same to treat cancerous tumors within a bodily tissue. A medical device system is included having at least one electric field generating circuit configured to generate one or more electric fields; control circuitry in communication with the electric field generating circuit, the control circuitry configured to control delivery of the one or more electric fields from the at least one electric field generating circuit; and two or more electrodes to deliver the electric fields to the site of a cancerous tumor within a patient. At least one electrode can be configured to be implanted. At least one electrode can be configured to be external. The control circuitry can cause the electric field generating circuit to generate one or more electric fields at frequencies selected from a range of between 10 kHz to 1 MHz.

A system and method for delivering TTFields are herein described. The system comprises, a first port operable to receive a lead of a first pad, a second port operable to receive a lead of a second pad, an electric field generator having circuitry operable to generate an electric signal having a frequency, a current, and a voltage, the frequency in a range of about 50 kHz to about 1 MHz, the circuitry operable to supply the electric signal to the first port and the second port, and to control the current to maintain the current within plus or minus 5% of a current threshold during a period of time in which at least one of a measured voltage and a measured impedance is below a threshold, and a power supply operable to supply power to the electric field generator.

Methods are disclosed for treating a subject having a disease or disorder comprising stimulating a nerve of the subject with a corrective stimulus pattern derived from a disease-specific, condition-specific, endogenous mediator-specific or pharmacologic agent-specific neurogram in an amount and manner effective to treat the disease or disorder.

Tumor treating fields (TTFields) can be delivered by implanting a plurality of sets of implantable electrode elements within a person's body. Temperature sensors positioned to measure the temperature at the electrode elements are also implanted, along with a circuit that collects temperature measurements from the temperature sensors. In some embodiments, an AC voltage generator configured to apply an AC voltage across the plurality of sets of electrode elements is also implanted within the person's body.

Described is a low voltage, pulsed electrical stimulation device for controlling expression of klotho, a useful protein, by tissues. Also described are methods of enhancing expression of klotho in cells.