The present disclosure relates to neuromuscular stimulation and sensing cuffs. The neuromuscular stimulation cuff has at least two fingers and a plurality of electrodes disposed on each finger. More generally, the neuromuscular stimulation cuff includes an outer, reusable component and an inner, disposable component. One or more electrodes are housed within the reusable component. The neuromuscular stimulation cuff may be produced by providing an insulating substrate layer, forming a conductive circuit on the substrate layer to form a conductive circuit layer, adhering a cover layer onto the conductive circuit layer to form a flexible circuit, and cutting at least one flexible finger from the flexible circuit. The neuromuscular stimulation cuff employs a flexible multi-electrode design which allows for reanimation of complex muscle movements in a patient, including individual finger movement.

Rehabilitating an impaired body part of a subject such as a stroke patient includes systems, devices, and methods using an orthosis system configured to attach to the impaired body part and to move or assist in movement of the impaired body part. A control system is configured to operate the orthosis system in a mode in which the orthosis system first allows the subject to move volitionally or attempt to move volitionally the impaired body part in a predefined motion and then operates to move or assist in the predefined motion of the impaired body part. Additional modes of operation include a brain computer interface mode of operation and a mode in which the orthosis system operates in a continuous passive mode of operation comprising a plurality of repetitions of an exercise to move the impaired body part.

The present disclosure provides methods and apparatus for evaluating tissue structure in damaged or healing tissue. The present disclosure also provides methods of identifying a patient at the onset of risk of pressure ulcer or at risk of the onset of pressure ulcer, and treating the patient with anatomy-specific clinical interventions selected, based on thermal imaging (TI). The present disclosure also provides methods of stratifying groups of patients based on risk of wound development and methods of reducing incidence of tissue damage in a care facility. The present disclosure also provides methods to analyze trends of TI intensities to detect tissue damage before it is visible, and methods to compare bisymmetric TI intensities to identify damaged tissue.

A lead introducer includes an integrated sheath/needle including a splittable sheath configured to split a into a first portion and a second portion, a needle having a length and a proximal end region, and a hub coupled to the proximal end regions of the splittable sheath and the needle and configured to split into a first portion and a second portion. The needle is permanently attached to either the first portion of the hub or the first portion of the splittable sheath (or both) so that when the hub is split into the first and second portions, the needle remains attached to the first portion of the hub or the first portion of the splittable sheath.

A control system for a movement reconstruction and/or restoration system for a patient, comprising a sampling module configured and arranged to sample signals describing directly and/or indirectly motion at a sampling rate of at least 50 Hz; at least one stimulation system configured and arranged to provide stimulation for movement reconstruction and/or restoration to the patient; a prediction module configured and arranged to provide a prediction of at least a next movement, especially movement stage and/or sequence, to reduce latency and to synchronize stimulation to the movement phase, wherein the control system further comprises at least one controller, the controller being configured and arranged to provide stimulation control signals to the stimulation system on the basis of the information obtained by the sampling module and the prediction provided by the prediction module.

A therapeutic or diagnostic device comprises a wearable electrodes garment including electrodes disposed to contact skin when the wearable electrodes garment is worn, and an electronic controller operatively connected with the electrodes. The electronic controller is programmed to perform a method including: receiving surface electromyography (EMG) signals via the electrodes and extracting one or more motor unit (MU) action potentials from the surface EMG signals. The method may further include identifying an intended movement based at least on features representing the one or more extracted MU action potentials and delivering functional electrical stimulation (FES) effective to implement the intended movement via the electrodes of the wearable electrodes garment. The method may further include generating a patient performance report based at least on a comparison of features representing the one or more extracted MU action potentials and features representing expected and/or baseline MU action potentials for a known intended movement.

A non-fixed shoulder brace is provided comprising: an affected shoulder support which is supported on an affected shoulder of a wearer; a waist support coupled to the wearer's waist; an affected arm mounting part in which the wearer's affected arm is inserted and which is supported by means of an affected shoulder strap member from the affected shoulder support; and an affected upper limb exercise assistance apparatus coupled to both ends of the waist support and disposed between the wearer's waist and the affected arm mounting part.

A prosthetic device includes a closed loop system for maintaining a predetermined concentration of a target ion in a region in proximity to a cell, such as a nerve cell. The device includes a controller and an ion-selective electrode assembly operatively connected to the controller, wherein the ion-selective electrode configuration is configured to sense the concentration of the target ion by potentiometric measurement and to convey the concentration to the controller. The controller is configured to modulate the current to the ion-selective electrode assembly based on the concentration of the target ion to control the concentration of the target ion so as to maintain the predetermined concentration of the target ion.

Techniques for placing implantable electrodes to treat sleep apnea, and associated devices, systems, and methods are disclosed herein. A representative method includes percutaneously implanting one or more signal delivery devices, each at or near a respective target signal delivery location in a patient. Each signal delivery device can include one or more electrodes, and individual ones of the electrodes can be positioned to produce a net positive protrusive motor response of the patient's tongue. The representative method further includes providing power to one or more of the electrodes from a wearable power source to cause the electrode(s) to deliver an electrical signal to the respective target signal delivery location(s) to produce the net positive protrusive motor response.

The invention relates generally to the fields of biology and health sciences. More particularly, the invention relates to compositions and methods for modulating cellular physiology and pathological processing using a combination of compounds that can be found in amniotic membrane tissue and umbilical cord tissue preparations.