An implantable medical device for stimulating a heart, includes a stimulation electrode configured to stimulate a first cardiac region of the heart, and a detection unit configured to detect an intracardiac electrogram at a second cardiac region (ventricle) of the heart. In operation, the device: delivers a stimulation pulse to the heart; evaluates a time and at least one morphologic parameter of a responsive signal of an intracardiac electrogram, wherein the at least one morphologic parameter is chosen from: an absolute value of the signal amplitude, a width of the signal, a positive, negative and/or total area under at least a part of the signal, and a number of occurrences and/or time of occurrence of zero crossings of the signal; and identifies a dislocation of the stimulation electrode if the time of the signal is below a first threshold value and the morphologic parameter exceeds a further threshold value.

Disclosed herein is an implantable electronic device. In one embodiment, the device has a modular header-feedthru assembly and a housing. The modular header-feedthru assembly has a conductor assembly, a feedthru coupled to the conductor assembly, and a polymer header that is injected molded about the conductor assembly and at least a portion of the feedthru. The housing is welded to the feedthru.

Disclosed herein is an implantable electronic device. In one embodiment, the device has a modular header-feedthru assembly and a housing. The modular header-feedthru assembly has a conductor assembly, a feedthru coupled to the conductor assembly, and a polymer header that is injected molded about the conductor assembly and at least a portion of the feedthru. The housing is welded to the feedthru.

A cardiac pacing system having a pulse generator for generating therapeutic electric pulses, a lead electrically coupled with the pulse generator having an electrode, a first sensor configured to monitor a physiological characteristic of a patient, a second sensor configured to monitor a second physiological characteristic of a patient and a controller. The controller can determine a pacing vector based on variables including a signal received from the second sensor, and cause the pulse generator to deliver the therapeutic electrical pulses according to the determined pacing vector. The controller can also modify pacing characteristics based on variables including a signal received from the second sensor.

A cardiac pacing system having a pulse generator for generating therapeutic electric pulses, a lead electrically coupled with the pulse generator having an electrode, a first sensor configured to monitor a physiological characteristic of a patient, a second sensor configured to monitor a second physiological characteristic of a patient and a controller. The controller can determine a pacing vector based on variables including a signal received from the second sensor, and cause the pulse generator to deliver the therapeutic electrical pulses according to the determined pacing vector. The controller can also modify pacing characteristics based on variables including a signal received from the second sensor.

The invention discloses a device for collection of tiny charges in the Nano-Coulomb-range and below, comprising at least one capacitor stack build by n capacitors and 2n switches (nϵN), at least one further capacitor outside the capacitor stack as buffer capacity, at least two additional switches and a DC input source. The n capacitors are dedicated to be sequentially charged by the DC input source one after the other, wherein the 2n switches in the capacitor stack couple the n capacitors sequentially to the DC input source. The at least one further capacitor is dedicated to be charged from the n capacitors of the capacitor stack at once. Furthermore, the invention discloses a method for small charge collection, comprising the steps of sequentially charging the n capacitors of the at least one capacitor stack by coupling one capacitor after the other to the DC input source by selectively closing the switches and discharging the n capacitors of the capacitor stack into at least one further capacitor outside the capacitor stack (nϵN). Additionally, the usage of the device or the method according to the invention to collect charges from sources with electrical potentials of a few millivolts is disclosed.

The invention discloses a device for collection of tiny charges in the Nano-Coulomb-range and below, comprising at least one capacitor stack build by n capacitors and 2n switches (nϵN), at least one further capacitor outside the capacitor stack as buffer capacity, at least two additional switches and a DC input source. The n capacitors are dedicated to be sequentially charged by the DC input source one after the other, wherein the 2n switches in the capacitor stack couple the n capacitors sequentially to the DC input source. The at least one further capacitor is dedicated to be charged from the n capacitors of the capacitor stack at once. Furthermore, the invention discloses a method for small charge collection, comprising the steps of sequentially charging the n capacitors of the at least one capacitor stack by coupling one capacitor after the other to the DC input source by selectively closing the switches and discharging the n capacitors of the capacitor stack into at least one further capacitor outside the capacitor stack (nϵN). Additionally, the usage of the device or the method according to the invention to collect charges from sources with electrical potentials of a few millivolts is disclosed.

A pacemaker system includes a drive-sense circuit (DSC) operably coupled to a pacemaker lead. The DSC generates a pace signal including electrical impulses based on a reference signal. The DSC provides the pace signal via the pacemaker lead to an electrically responsive portion of a cardiac conductive system of a subject to facilitate cardiac operation of a cardiovascular system of the subject. The DSC senses, via the pacemaker lead, cardiac electrical activity of the cardiovascular system of the subject that is generated in response to the pace signal and electrically coupled into the pacemaker lead and generates a digital signal that is representative of the cardiac electrical activity of the cardiovascular system of the subject that is sensed via the pacemaker lead. The DSC provides digital information to one or more processing modules that includes and/or is coupled to memory and that provide the reference signal to the DSC.

In some examples, the disclosure describes a medical assembly that includes a stent including a primary electrode, where the stent is configured to expand from a collapsed configuration to an expanded configuration, a secondary electrode, and an energy source configured to deliver an electrical signal between the primary electrode and the secondary electrode through a fluid in contact with the primary electrode to cause the fluid to undergo cavitation to generate a pressure pulse wave within the fluid.

In some examples, the disclosure describes a medical assembly that includes a stent including a primary electrode, where the stent is configured to expand from a collapsed configuration to an expanded configuration, a secondary electrode, and an energy source configured to deliver an electrical signal between the primary electrode and the secondary electrode through a fluid in contact with the primary electrode to cause the fluid to undergo cavitation to generate a pressure pulse wave within the fluid.