A balloon catheter comprising: a first shaft having a first lumen and a second lumen; a second shaft located distal to the first shaft; a balloon located distal to the second shaft; and a tubular member that is disposed inside the balloon and has a light transmittance of 90% or more; wherein: the first shaft is made of a resin; a cross-sectional area of the resin forming the first shaft is larger than a cross-sectional area of either the first lumen or the second lumen, which has a larger cross-sectional area, in a cross section perpendicular to a longitudinal direction; a proximal end of the tubular member is joined to a distal end of the first lumen; a proximal end of the balloon is joined to the second shaft; and a distal end of the balloon is joined to the tubular member.

A UV light delivery device for performing intra-corporeal ultraviolet therapy is provided. The device includes an elongated body separated by a proximal end and a distal end. The device also includes a UV light source configured to be received at the receiving space. In some examples, the UV light source is configured to emit light with wavelengths with significant intensity between 320 nm and 410 nm and is utilized in conjunction with an endotracheal tube or a nasopharyngeal airway.

A method of cholecystitis treatment according to an aspect of the present disclosure comprises a step A including contacting inner walls of a gallbladder to each other by constricting the gallbladder and a step B including maintaining the inner walls of the gallbladder contacting each other.

A balloon catheter (1) comprising: a first shaft (10) having a first lumen (11) and a second lumen (12); a second shaft (20) located distal to the first shaft (10); a balloon (30) located distal to the second shaft (20); and an optical fiber (40) disposed inside the balloon (30); wherein: the first shaft (10) is made of a resin; a cross-sectional area of the resin forming the first shaft (10) is larger than a cross-sectional area of either the first lumen (11) or the second lumen (12), which has a larger cross-sectional area, in a cross section perpendicular to a longitudinal direction; the optical fiber (40) is joined to a distal end (11d) of the first lumen (11); a proximal end (30p) of the balloon (30) is joined to the second shaft (20); and a distal end (30d) of the balloon (30) is joined to the optical fiber (40).

An ingestible gastrointestinal phototherapy device has a spherocylindrical body of non-digestible material having a cylindrical midsection and transparent light portals at ends thereof. The cylindrical midsection has control circuitry and a power source therein and each light portal is transparent and comprises an array of bioactive light source elements therein emitting bioactive light therefrom and being operably coupled to the control circuitry and power source.

Provided is a swallowable capsule for providing phototherapy to a patient's gastrointestinal (GI) tract, the capsule including a power supply, one or more phototherapeutic light sources, a speed determination unit for calculating speed of movement of the capsule in the GI tract, and a controller unit for activating one or more of the one or more light sources for delivering a therapeutic illumination dose to a target site in the GI tract, based, at least in part, on a determined speed. Related apparatus and methods are also described.

Systems, methods, and computer-readable media for enabling ultraviolet radiation treatments are provided.

A system that provides neuroprotection or neuroregeneration to biological tissue includes a pulsed energy having energy parameters including a wavelength or frequency, a duty cycle and a pulse train duration. A delivery device applies the pulsed energy to neural elements of the target tissue having a chronic progressive disease or at risk of having a chronic progressive disease. The delivery device applies the pulsed energy for a predetermined total pulse train duration such that the target tissue temperature is raised sufficiently to provide neuroprotection or neuroregeneration to the neural elements of the target tissue, while maintaining the average temperature rise of the target tissue at or below a predetermined level so as not to permanently damage the target tissue.

A UV light delivery device for performing intra-corporeal ultraviolet therapy is provided. The device includes an elongated body separating a proximal end and a distal end. The device also includes a UV light source configured to be received at the receiving space and a cooling tube. In some examples, the UV light source is configured to emit light with wavelengths with a desired intensity between 320 nm and 410 nm and is utilized in conjunction with an endotracheal tube or a nasopharyngeal airway.

The present invention provides methods for treating, reducing the severity, or inhibiting the growth of cancer (e.g., skin cancer). The methods of the present invention comprise administering to a subject in need thereof a therapeutically effective amount of a programmed death 1 (PD-1) antagonist (e.g., an anti-PD-1 antibody). In certain embodiments, the skin cancer is cutaneous squamous cell carcinoma or basal cell carcinoma.