Systems and methods for positioning in medical systems are provided. The system may obtain data associated with a scanning range of a subject. The system may also obtain an image of the subject on a couch of a medical radiation device. The image may be acquired by an imaging device when the couch is at a first position. The system may determine a position of the scanning range of the subject in the image. The system may further cause, based on the position of the scanning range in the image, the couch to move to a second position. The scanning range of the subject may be in a radiation region of the medical radiation device when the couch is located at the second position.

A radiation delivery system that includes a gantry to extend along one or more axes. The gantry is to provide a continuous rotation. The radiation delivery system includes a linear accelerator (LINAC) coupled to the gantry. The LINAC is to generate a treatment beam. The radiation delivery system includes a rotary joint coupled to the gantry. The rotary joint provides a physical connection from the LINAC to an external system that is positioned off the gantry. The physical connection is to transport at least one of a cooling liquid or air.

Disclosed herein are systems and methods for adapting and/or updating radiotherapy treatment plans based on biological and/or physiological data and/or anatomical data extracted or calculated from imaging data acquired in real-time (e.g., during a treatment session). Functional imaging data acquired at the time of radiation treatment is used to modify a treatment plan and/or dose delivery instructions to provide a prescribed dose distribution to patient target regions. Also disclosed herein are methods for evaluating treatment plans based on imaging data acquired in real-time.

The disclosure provides a system for EGRT. The system may include a radiotherapy device for treating a subject. The radiotherapy device may include a scintillation camera that is directed at an ROI of the subject. The subject may be injected with a radioactive tracer or implanted with a radioactive marker before treatment. The ROI may undergo a physiological motion during the treatment. The system may deliver a treatment session to the subject by the radiotherapy device. During the treatment session, the system may acquire a target image of the ROI indicative of a distribution of the radioactive tracer or the radioactive maker in the ROI by the scintillation camera, and adapt a radiation beam to be delivered to the subject with respect to the physiological motion of the ROI by adjusting the radiation beam based on the target image.

A detector module system for positron emission tomography including a plurality of gamma ray detector modules. Each pair of one detector module and one interconnection element includes mutually engaging locking means for releasably connecting the detector module to the interconnection element. Further each interconnection element includes locking means for releasably connecting at least two detector modules to said interconnection element. Further each of said gamma ray detector modules includes a sensor adapted to detect gamma radiation occurring from short-lived radionuclides radiating from a body and to generate a radiation output corresponding to the detected gamma radiation, and the detector module system comprises a processing circuitry adapted to receive said radiation output from each of the gamma ray detector modules and to generate a resulting radiation representation for the positron emission tomography event, based on the received radiation output. Also, a medical apparatus for positron emission tomography.

A system for radiation therapy may obtain a plurality of sets of motion data each of which corresponds to one of a plurality of motion phases of a subject. A set of motion data corresponding to a motion phase may include first physiological motion data and second physiological motion reflecting a physiological motion during the motion phase. The first physiological motion data and the second physiological motion data may be collected via a medical imaging device and a first motion sensor, respectively. The system may also direct a radiotherapy device to deliver a radiation treatment to the subject according to a treatment plan. During the radiation treatment, the system may obtain target physiological motion data reflecting the physiological motion of the subject, the target physiological motion data being collected via a second motion sensor; and adjust the treatment plan to adapt to the physiological motion of the subject.

An image-guided radiation therapy apparatus comprises: a high-energy ray source configured for radiation therapy of an object; and a KV ray source, a first and second PET detectors, and a CT detector for KV CT and PET imaging for guiding the radiation therapy. The KV ray source is placed on, or at an inner or outer side of the first PET detector; the second PET detector and the CT detector are configured to receive the KV ray to perform KV CT imaging; the PET detectors are further configured to receive gamma ray emitted by the object to perform PET imaging.

Disclosed herein are systems and methods for monitoring calibration of positron emission tomography (PET) systems. In some variations, the systems include an imaging assembly having a gantry comprising a plurality of positron emission detectors. A housing may be coupled to the gantry, and the housing may include a bore and a radiation source holder spaced away from a patient scan region within the bore. A processor may be configured to receive positron emission data from the positron emission detectors and to distinguish the positron emission data from the radiation source holder and from the patient scan region. A fault signal may be generated when the positron emission data from the radiation source holder exceeds one or more threshold parameters or criteria.

An approach for enhancing radiation treatment of target tissue includes identifying a target volume of the target tissue; causing disruption of vascular tissue in a region confined to the target volume so as to define the target volume; based at least in part on the disruption of the vascular tissue, determining a radiation treatment plan having a reduced radiation dose for treating the target tissue; and exposing the target volume to the reduced radiation dose based on the radiation treatment plan.

A system including a diagnostic-quality CT scanner for imaging a patient, the diagnostic-quality CT scanner having an imaging isocenter and a radiation therapy device positioned adjacent the diagnostic-quality CT scanner, the radiation therapy device including a gantry carrying a radiation therapy beam source and having a radiation therapy isocenter separate from the imaging isocenter of the diagnostic-quality CT scanner. The system including a couch configured to position the patient for imaging and for radiation therapy by translating the patient between the diagnostic quality CT scanner and the radiation therapy device.