A device (1) for obtaining a biological sample that includes a blood collection device (10) and a vibration device (80) removably attachable to the blood collection device that provides pain relief is disclosed. The vibration device of the present disclosure provides pain relief to a patient by vibrating the blood collection device. The vibration device can be attached to the blood collection device before it is placed onto a finger to provide pain relief during the finger lancing as well as to aid blood flow from the finger into a collection container during the collection process.

A device is used in combination with a fluid pressure source and a replaceable sampling tube having a pointed cannula section and a hollow for capillary blood collection. The device is provided with: a body defining a bore extending along an axis; a first flow path in fluid communication with the fluid pressure source; a rotor fitting in the bore and being capable of spinning in both directions about the axis; a boss section extending along the axis and so dimensioned as to rotatably support the sampling tube coaxially with the axis and expose the cannula section out of the boss section; and a detachable fastening binding the sampling tube to the rotor so as to set the sampling tube into rotation concentric with the axis and establish fluid communication between the first flow path and the hollow of the sampling tube.

A device and method for collecting blood from an anatomical feature of a mammalian subject, the device including a vibrating plate assembly structured and arranged to retain the anatomical feature, a first biasing device releasably attachable to the vibrating plate assembly, a housing portion releasably connectable to the vibrating plate assembly, and a plurality of vibrating motors located beneath the vibrating plate assembly, such that vibrations translated to the anatomical feature enhance blood collection, such that the first biasing device constricts blood flow to the collection point on the anatomical feature, causing blood to pool therein, and low frequency and/or high amplitude vibrations cause vasodilation, encouraging blood flow through the capillaries at the collection point.

Disclosed herein are systems and methods for visualizing a target anatomy of a patient in preparation of a medical procedure. The method can include providing a visualization device (400) that probes the target anatomy and provides a display to the operator. The method can include positioning the visualization device at a location near the target anatomy. The method can further include directing a medical instrument towards a target trajectory displayed on the visualization device. The visualization device can have a body that defines two surface areas. The visualization device can include transducers along one surface area of the device to capture the target anatomy. A user interface (420) can be disposed on another surface area of the device. The display can include parallax for adjusting the visualization.

In one aspect, the present disclosure relates to a method for harvesting biological tissue. In some embodiments, the method includes providing a device having a plurality of segments of hollow tubes, each hollow tube having at least one point at the distal end of the hollow tube, the plurality of segments forming a two dimensional array of hollow tubes, wherein each segment can include a plurality of hollow tubes; positioning the two dimensional array of hollow tubes proximal to an upper surface of a biological tissue; advancing a first segment of the two dimensional array of hollow tubes into the biological tissue to sever portions of the biological tissue from the surrounding tissue; raising the first segment of the two dimensional array of hollow tubes such that the biological tissue remains in each of the hollow tubes of the first segment; advancing a second segment of the two dimensional array of hollow tubes into the biological tissue to sever portions of the biological tissue from the surrounding tissue; and raising the second segment of the two dimensional array of hollow tubes such that the biological tissue remains in each of the hollow tubes of the second segment.

A vacuum assisted lancing system can include a tubular body having a vacuum chamber, a lancing mechanism configured to removably couple with a lance, a vacuum mechanism including a piston slideably coupled within the body, a release mechanism for selectively holding the vacuum mechanism in an energized state and an opening for allowing fluid communication between the vacuum chamber and an atmosphere. A method of manipulating a surface for blood extraction can include coupling a lancing system to the surface, blocking an opening, creating a vacuum, moving a lance coupler from a first position distal from the surface to a second position proximal to the surface, maintaining the vacuum for a period of time and commencing dissipation of the vacuum by unblocking the opening.

A device and method for collecting blood from an anatomical feature of a mammalian subject, the device including a vibrating plate assembly structured and arranged to retain the anatomical feature, a first biasing device releasably attachable to the vibrating plate assembly, a housing portion releasably connectable to the vibrating plate assembly, and a plurality of vibrating motors located beneath the vibrating plate assembly, such that vibrations translated to the anatomical feature enhance blood collection, such that the first biasing device constricts blood flow to the collection point on the anatomical feature, causing blood to pool therein, and low frequency and/or high amplitude vibrations cause vasodilation, encouraging blood flow through the capillaries at the collection point.

An arrangement for producing a sample of body fluid from a wound opening created in a skin surface at a sampling site includes at least one skin-penetration member having a first end configured to pierce the surface of the skin, and a inner lumen in communication with the first end; at least one actuator operatively associated with the at least one skin-penetration member; and at least one catalyst device configured to cause perfusion of body fluid at the sampling site; wherein the at least one actuator is configured to locate the at least one skin-penetration member so as to obstruct the wound opening while transporting body fluid through the inner lumen. Associated methods are also described.

The present disclosure is directed to wearable or insertable devices that allow for ongoing sampling and analysis of biomarkers and self-cleaning. In various embodiments, an apparatus may include a base (102) defining at least one reservoir (104), and at least one microneedle (106, 306, 406, 506, 606, 706, 806, 906) extending from the base. The at least one microneedle may define an inner lumen (409, 509, 609, 709, 809, 909) that fluidly couples the at least one reservoir with tissue of the patient. A mechanically responsive material (670, 770, 870) on an inner surface of the at least one microneedle defining the inner lumen may be reactive to various stimuli to undergo various mechanical responses, such as one mechanical response that purges fluid from the inner lumen of the at least one microneedle and another mechanical response that draws fluid into the inner lumen of the at least one microneedle.

A device and method for collecting blood from an anatomical feature of a mammalian subject, the device including a vibrating plate assembly structured and arranged to retain the anatomical feature, a first biasing device releasably attachable to the vibrating plate assembly, a housing portion releasably connectable to the vibrating plate assembly, and a plurality of vibrating motors located beneath the vibrating plate assembly, such that vibrations translated to the anatomical feature enhance blood collection, such that the first biasing device constricts blood flow to the collection point on the anatomical feature, causing blood to pool therein, and low frequency and/or high amplitude vibrations cause vasodilation, encouraging blood flow through the capillaries at the collection point.