A blood glucose detection device includes a carrier body, a flow-guiding actuator, a microneedle patch, a sensor and a controlling chip. The carrier body has a liquid guiding channel, a compressing chamber and a liquid storage chamber. The flow-guiding actuator seals the compressing chamber. The microneedle patch is attached on the carrier body and has plural hollow microneedles. The sensor is disposed within the liquid storage chamber. The controlling chip is disposed on the carrier body. The plural hollow microneedles puncture the skin of a human subject with minimal invasion. The controlling chip controls the flow-guiding actuator to actuate and the tissue fluid is sucked into the liquid storage chamber through the plural hollow microneedles, whereby the sensor detects the blood glucose of the tissue fluid to generate and transmit the measured data to the controlling chip. The controlling chip can generate monitoring information by calculating the measured data.

Described here are meters and methods for sampling, transporting, and/or analyzing a fluid sample. The meters may include a meter housing and a cartridge. In some instances, the meter may include a tower which may engage one or more portions of a cartridge. The meter housing may include an imaging system, which may or may not be included in the tower. The cartridge may include one or more sampling arrangements, which may be configured to collect a fluid sample from a sampling site. A sampling arrangement may include a skin-penetration member, a hub, and a quantification member.

The various embodiments disclosed herein are devices that deliver electrical stimulation and/or vibration stimulation to the surface of skin in proximity to insulin injections and/or glucose testing in order to decrease or eliminate the pain of these procedures.

Disclosed herein is an apparatus for inserting a needle and a method for cannulation of a blood vessel. The apparatus can include a targeting assembly to identify a target location and an insertion path for the needle. The apparatus can further include a frame and insertion assembly to hold and place the needle. A user interface can be provided to provide feedback to an operator. The apparatus can include an adjustable band that engages a body portion of the patient. The method can include placing and securing the frame to the body portion. The method can further include locating the target location and inserting the needle through a target area.

In one aspect, the present disclosure relates to a method for harvesting biological tissue. In some embodiments, the method includes providing a device having a plurality of segments of hollow tubes, each hollow tube having at least one point at the distal end of the hollow tube, the plurality of segments forming a two dimensional array of hollow tubes, wherein each segment can include a plurality of hollow tubes; positioning the two dimensional array of hollow tubes proximal to an upper surface of a biological tissue; advancing a first segment of the two dimensional array of hollow tubes into the biological tissue to sever portions of the biological tissue from the surrounding tissue; raising the first segment of the two dimensional array of hollow tubes such that the biological tissue remains in each of the hollow tubes of the first segment; advancing a second segment of the two dimensional array of hollow tubes into the biological tissue to sever portions of the biological tissue from the surrounding tissue; and raising the second segment of the two dimensional array of hollow tubes such that the biological tissue remains in each of the hollow tubes of the second segment.

The various embodiments disclosed herein are devices that deliver electrical stimulation and/or vibration stimulation to the surface of skin in proximity to insulin injections and/or glucose testing in order to decrease or eliminate the pain of these procedures.

A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

An arrangement for producing a sample of body fluid from a wound opening created in a skin surface at a sampling site includes at least one skin-penetration member having a first end configured to pierce the surface of the skin, and a inner lumen in communication with the first end; at least one actuator operatively associated with the at least one skin-penetration member; and at least one catalyst device configured to cause perfusion of body fluid at the sampling site; wherein the at least one actuator is configured to locate the at least one skin-penetration member so as to obstruct the wound opening while transporting body fluid through the inner lumen. Associated methods are also described.

A device and method for collecting blood from an anatomical feature of a mammalian subject, the device including a vibrating plate assembly structured and arranged to retain the anatomical feature, a first biasing device releasably attachable to the vibrating plate assembly, a housing portion releasably connectable to the vibrating plate assembly, and a plurality of vibrating motors located beneath the vibrating plate assembly, such that vibrations translated to the anatomical feature enhance blood collection, such that the first biasing device constricts blood flow to the collection point on the anatomical feature, causing blood to pool therein, and low frequency and/or high amplitude vibrations cause vasodilation, encouraging blood flow through the capillaries at the collection point.

In one aspect, the present disclosure relates to a method for harvesting biological tissue. In some embodiments, the method includes providing a device having a plurality of segments of hollow tubes, each hollow tube having at least one point at the distal end of the hollow tube, the plurality of segments forming a two dimensional array of hollow tubes, wherein each segment can include a plurality of hollow tubes; positioning the two dimensional array of hollow tubes proximal to an upper surface of a biological tissue; advancing a first segment of the two dimensional array of hollow tubes into the biological tissue to sever portions of the biological tissue from the surrounding tissue; raising the first segment of the two dimensional array of hollow tubes such that the biological tissue remains in each of the hollow tubes of the first segment; advancing a second segment of the two dimensional array of hollow tubes into the biological tissue to sever portions of the biological tissue from the surrounding tissue; and raising the second segment of the two dimensional array of hollow tubes such that the biological tissue remains in each of the hollow tubes of the second segment.