A lancing device includes a housing, a lancet carrier translational within the housing, a drive spring for propelling the lancet carrier through a translational lancing stroke, and a charging mechanism. The charging mechanism includes a first cam member that is rotatable relative to the housing, a second cam member that abuts the first cam member, is coupled to the lancet carrier, and is restricted from rotation relative to the housing, and a rotatable handle co-rotationally attached to the first cam member. Rotation of the handle rotates the first cam member with it, causing the first cam member to rotate against the second cam member, which in response traverses axially because it is restricted from rotation, thereby retracting the lancet carrier to a retracted or charged state.

The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, in some cases, may be interfaced with external equipment to determine an analyte contained within a fluid contained within or collected by the device. For example, the device may be mounted or engaged on an external holder, the device may include a port for transporting fluid out of the device, the device may include a window for interrogating a fluid contained within the device, or the like. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.

In some aspects, an analyte sensor is provided for detecting an analyte concentration level in a bio-fluid sample. The analyte sensor may include one or more conductors received in a hollow portion of a hollow member. The first conductor may be made, at least in part, of a semiconductor material and an active region may be provided in contact with at least the first conductor. The analyte sensor may, in one aspect, include a lancet and an integrated sensor. Manufacturing methods and apparatus and systems utilizing the analyte sensors are provided, as are numerous other aspects.

A drawworks for a drilling device for lowering and hoisting a load such as a drill string or parts thereof includes a frame comprising a first bearing point, a second bearing point, and a third bearing point, a winding drum, and a first bearing device connected to the frame for the winding drum. The first bearing device is arranged so that a center of respective bearing forces is located at each of the first bearing point, at the second bearing point, and at the third bearing point.

An analytical magazine is proposed, which comprises a plurality of analytical aids accommodated in chambers. The analytical magazine is arranged to be accommodated in at least two orientations in an analytical system. The analytical magazine is furthermore arranged to provide the analytical system, in the orientations, in each case with a plurality of analytical aids. At least one sampling movement can be executed by means of the analytical aids. The analytical magazine is arranged to make a remagazining of the analytical aids possible.

Pen-type lancing device of the re-usable type wherein a lancet body having a needle/tip is inserted; standard spring type actuator (urging member); skin touching forward face having a textured surface for pain relieve; sleeve having internal stop(s) so that the lancet does not overshoot. Also a pen-type lancing device of the re-usable type wherein a lancet body having a needle/tip is inserted; elastomer type urging member for driving the lancet; triggering means (denoted actuating means). Further a pen-type lancing device of the reusable type wherein a lancet body having a needle/tip is inserted; standard spring type actuator (urging member) for driving the lancet; alignment splines and cooperating alignment portion(s) for guiding the lancet movement. Even further a method of assembling a blood sampling device in which it does not matter what rotational orientation the components are assembled in.