An automated insertion assembly includes a first dermal perforation assembly configured to releasably engage a first subdermal device. A first actuation assembly is configured to drive the first dermal perforation assembly into a user's skin to a first depth and drive the first subdermal device into the user's skin to a second depth. The second depth is greater than the first depth.

A point-of-care blood collection and dispensing device for use with a luer lock access device, the point-of-care collection and dispensing device including a distal engagement portion, wherein at least a part of the distal engagement portion is configured to engage a needle of the luer lock access device, and a sidewall portion, wherein at least part of the sidewall portion is formed of a flexible material capable of being compressed. The device also includes a fluid chamber configured to hold a blood sample, the fluid chamber bound at least partially by the distal engagement portion and the sidewall portion, as well as an opening, wherein the opening is sized and configured to dispense a small volume of the blood sample held within the fluid chamber when the sidewall portion is compressed.

A patch-sized fluid delivery device may include a reusable portion and a disposable portion. The disposable portion may include components that come into contact with the fluid, while the reusable portion may include only components that do not come into contact with the fluid. Redundant systems, such as redundant controllers, power sources, motor actuators, and alarms, may be provided. Alternatively or additionally, certain components can be multi-functional, such a microphones and loudspeakers that may be used for both acoustic volume sensing and for other functions and a coil that may be used as both an inductive coupler for a battery recharger and an antenna for a wireless transceiver. Various types of network interfaces may be provided in order to allow for remote control and monitoring of the device.

Systems and methods for autonomous intravenous needle insertion are disclosed herein. In an embodiment, a system for autonomous intravenous insertion include a robot arm, one or more sensors pivotally attached to the robot arm for gathering information about potential insertion sites in a subject arm, a medical device pivotally attached to the robot arm, and a controller in communication with the sensors and the robot arm, wherein the controller receives the information from the sensors about potential insertion sites, and the controller selects a target insertion site and directs the robot arm to insert the medical device into the target insertion site.

Blood sample optimization systems and methods are described that reduce or eliminate contaminates in collected blood samples, which in turn reduces or eliminates false positive readings in blood cultures or other testing of collected blood samples. A blood sample optimization system can include a blood sequestration device located between a patient needle and a sample needle. The blood sequestration device can include a sequestration chamber for sequestering an initial, potentially contaminated aliquot of blood, and may further include a sampling channel that bypasses the sequestration chamber to convey likely uncontaminated blood between the patient needle and the sample needle after the initial aliquot of blood is sequestered in the sequestration chamber.

An implantation device for prompt subcutaneous implantation of a sensor to measure a physiological signal of an analyte in a biofluid of a living body is disclosed. The implantation device includes a housing, an implantation module, a detachable module and a bottom cover. The housing has a bottom opening. The implantation module includes an implanting device and a needle extracting device. The detachable module includes the sensor detachably engaged with the implantation module; and a base configured to mount the sensor thereon. The bottom cover is detachably coupled to the bottom opening so that the housing and the bottom cover together form an accommodating space. The implantation module and the detachable module are accommodated in the accommodating space. The bottom cover has an operating portion configured to bear a force, and a supporting portion is formed on the opposite end of the operating portion.

Provided herein is a blood collection device having a tube having a proximal end, a distal end, and a sidewall therebetween defining an interior, the interior configured to receive a blood sample through one or more openings at the distal end of the tube when the distal end of the tube is positioned in a blood vessel and an obturator slidably disposed relative to the tube and received within the interior of the tube.

A catheter extension set is disclosed having a body defining a channel to direct a biological fluid therethrough, a connection port defined in the body, in which an extension tube is fluidly coupled to the connection port, a vented access port in fluid communication with the extension tube, the vented access port spaced apart from the connection port, a non-integrated catheter removably connectable with the body to direct a biological fluid into the body, and a distal access port defined in the body, the distal access port configured to be in fluid communication with a removable sample collection container. An initial biological fluid volume directed through the body is directed into the extension tube via the connection port and into the vented access port.

A blood sample collection system includes a blood access device having a fluid flow path and a diagnostic device configured to receive a sample of blood, where the diagnostic device is in fluid communication with the fluid flow path, and where the diagnostic device is configured to be detached from the blood access device.

An apparatus for determining the volume of fluid dispensed. The apparatus has an acoustic volume sensor that acoustically excites a reference volume and a measurement chamber with a loudspeaker and measures the acoustic response with microphones acoustically coupled to the reference and the measurement chamber. The loudspeaker and sensing microphones are connected to the measurement chamber by separate ports. A detachable dispensing chamber is coupled to the acoustic volume sensor. The volume of the fluid dispensed is determined by a processor based on the acoustic response of the microphones to acoustic excitement by the loudspeaker.