A biological fluid collection device that is adapted to receive a blood sample is disclosed. The biological fluid collection device includes a housing, a puncturing element transitionable between a pre-actuated position wherein the puncturing element is retained within the housing and a puncturing position wherein at least a portion of the puncturing element extends through the housing, and a cartridge removably connectable to a portion of the housing. After collecting a blood sample, the cartridge is removable from the housing and the cartridge is able to transfer the blood sample to a point-of-care testing device. The biological fluid collection device provides a closed system that reduces the exposure of a blood sample and provides fast mixing of a blood sample with a sample stabilizer.

A device for collecting a physiological sample from a subject includes a lancet and a cartridge configured to couple to the lancet. The needle is configured to puncture the subject's skin. The lancet is configured to automatically deploy the needle when coupled to the lancet which allows the needle to puncture the subject's skin and draw a physiological sample. The device further includes a vial disposed within the cartridge. The vial is configured to receive the drawn physiological sample.

A method of dispensing a therapeutic fluid from a line includes providing an inlet line connectable to an upstream fluid source. The inlet line is in downstream fluid communication with a pumping chamber. The pumping chamber has a pump outlet. The method also includes actuating a force application assembly so as to restrict retrograde flow of fluid through the inlet while pressurizing the pumping chamber to urge flow through the pump outlet. A corresponding system employs the method.

A handheld lancing device having anesthetic feature includes a housing removably retaining a disposable lancet. A carriage suspended within the housing by an isolation assembly may receive the lancet. A motor in mechanical communication with the lancet produces vibrations transmitted to contact surface, which vibrate a target lancing site prior to and during piercing. The target site is vibrated for a predetermined period of time before deploying the lancet. The isolation assembly permits movement of the carriage and/or lancet within the housing in one direction while limiting movement in other directions, and further dampens the vibrations of the motor from the housing held by the user. A force sensor detects force applied by the pressing of the contact surface against the skin of the patient. An indicator(s) perceivable to the user identifies when predefined positions of the lancet are reached for initiating vibration then triggering the lancet.

The present disclosure provide a blood collection needle, including a cylinder body provided with a needle core and a needle body therein, in which the needle body is disposed in the needle core and a needle point of the needle body protrudes from a front end of the needle core, and a convex strip extending in a front-rear direction is disposed on an inner peripheral wall of the cylinder body; a launch spring disposed in the cylinder body, stopped against between the cylinder body and the needle core, and configured to press the needle core forward; a launch sleeve having a pushing portion, disposed in the cylinder body and movable from a first position to a second position in the front-rear direction; and a connecting ring disposed in the cylinder body and located in rear of the launch sleeve.

The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.

Fill stations and base stations are provided for personal pump systems. The fill stations may be opened and closed to accept a reservoir and to allow fluid to be introduced into the reservoir for use with personal pump systems. The fill stations may hold the reservoir at a tilt relative to an underlying surface and may discourage overfilling of the reservoir. The filling stations may also include viewing windows having fluid lines marked thereon for indicating volume of fluid within the reservoir.

A patch-sized fluid delivery device may include a reusable portion and a disposable portion. The disposable portion may include components that come into contact with the fluid, while the reusable portion may include only components that do not come into contact with the fluid. Redundant systems, such as redundant controllers, power sources, motor actuators, and alarms, may be provided. Alternatively or additionally, certain components can be multi-functional, such a microphones and loudspeakers that may be used for both acoustic volume sensing and for other functions and a coil that may be used as both an inductive coupler for a battery recharger and an antenna for a wireless transceiver. Various types of network interfaces may be provided in order to allow for remote control and monitoring of the device.

A tail pressing type disposable safety lancet includes a shell, a lancet core, a spring and tail cover. The shell has an elastic arm for locking the lancet core, wherein: the tail cover has an active locking part for locking and the elastic arm has a passive locking part for locking correspondingly; the positions, the fitting time of the active locking part and the passive locking part correlate with the active and passive unlocking parts; when the tail cover is pressed during use, it forces the lancet core to unlock for ejection and puncturing, and the tail cover and elastic arm enter the locking state and cannot be used again. After use of the safety lancet, the tail cover permanently locks on the elastic arm of the shell, ensuring the safety of single use, and the user visually recognizes the tail cover is retracted at the tail of the shell.

An applicator for applying a microneedle patch to a skin of a subject, comprising a base having a skin-side end and a holder for holding the microneedle patch. Two or more contact parts are movable over the skin and away from each other to stretch the skin. The applicator further comprising an interface for an actuator. The actuator actuates a movement of the microneedle patch relative to the skin-side end to penetrate at least into the stratum corneum of the epidermis of the skin with the microneedle. A microneedle patch comprising a skin-adhesive surface for attaching the patch to the skin of a subject. The patch has one or more projecting microneedles. A stiffening body stiffens the patch in at least a parallel direction parallel to the skin-adhesive surface in a region of the skin-adhesive surface which includes the microneedle.