An inserting device includes a main casing, a bracket, a first elastic component, an inserting assembly and a second elastic component. The main casing has a position-limiting portion and a first holding portion. The bracket is disposed in the main casing and has a second holding portion. The first elastic component is disposed between the main casing and the bracket, and the first holding portion holds the bracket. The inserting assembly is disposed in the main casing. The second elastic component is disposed between the inserting assembly and the bracket. The position-limiting portion limits the second holding portion, such that the second holding portion holds the inserting assembly on the bracket. When the bracket is released by the first holding portion, the bracket, the second elastic component and the inserting assembly move by the elastic force of the first elastic component, the second holding portion is departed from the position-limiting portion, and the inserting assembly is restored by an elastic force of the second elastic component. Moreover, a blood collection device including the inserting device is also provided.

A device for collection of interstitial fluid that can perform needle assembly actuation, skin piercing, needle assembly repositioning, and secondary skin piercing. Also described is a method for extraction of ISF that results in a significant volume of extracted ISF. The presently described device and method can be used for interstitial fluid extraction and collection in the medical diagnostics field.

A lancing device with an ejector that is movably retained with a housing in proximity to a lancet and is selectively movable between a home position, a first eject position, an intermediate position defined by contact of the ejector with the lancet, and a second eject position. The ejector is rotatable to move from the home to first eject position and is linearly translatable to move between the first and second eject positions. The ejector includes an arm that extends within the housing and engages the lancet, an exterior portion that is actuated by a user, and a post extending therebetween. The post extends through a slot in the housing which limits the linear movement and direction of the ejector. Upon rotation of the ejector, the arm extends through an opening at the rear of the carriage holding the lancet to permit access to the lancet.

Blood sampling device comprising a lancet body supporting a lancet tip, said lancet being moveably mounted within a housing, an urging member configured to urge said lancet forwardly in said housing in use from a primed position in which said lancet tip is located within a passage to a lancing position in which said lancet tip projects through an aperture in the forward end of the housing and a removable safety cap. The housing and said safety cap comprise cooperating abutment surfaces and cooperating stop surfaces, with the safety cap being rotatable in a first direction from a first blocked position in which said cooperating abutment surfaces are in abutment alignment to prevent removal of said safety cap from said housing to a second position in which said cooperating abutment surfaces are not in abutment alignment such that said safety cap can be removed from said housing; and wherein said stop surfaces cooperate to limit further rotation of said safety cap in said first direction when said safety cap is in said second position.

The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, in some cases, may be interfaced with external equipment to determine an analyte contained within a fluid contained within or collected by the device. For example, the device may be mounted or engaged on an external holder, the device may include a port for transporting fluid out of the device, the device may include a window for interrogating a fluid contained within the device, or the like. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.

Devices and methods for withdrawing bodily fluid from a subject are disclosed herein. In some embodiments, a handheld device can include a housing having an opening, a skin-piercing assembly, and an actuator coupled to the skin-piercing assembly. The skin-piercing assembly can include a casing, a drive member pivotably mounted within the casing and carrying a blade, and a biasing member coupling the drive member to the casing. The actuator can be movable relative to the housing from a first position to a second position. In the first position, the drive member can engage the casing to maintain the biasing member in a biased configuration. Movement of the actuator from the first position to the second position can disengage the drive member from the casing to permit the biasing member to drive the blade at least partially through and/or across the opening in the base.

A patch-sized fluid delivery device may include a reusable portion and a disposable portion. The disposable portion may include components that come into contact with the fluid, while the reusable portion may include only components that do not come into contact with the fluid. Redundant systems, such as redundant controllers, power sources, motor actuators, and alarms, may be provided. Alternatively or additionally, certain components can be multi-functional, such a microphones and loudspeakers that may be used for both acoustic volume sensing and for other functions and a coil that may be used as both an inductive coupler for a battery recharger and an antenna for a wireless transceiver. Various types of network interfaces may be provided in order to allow for remote control and monitoring of the device.

An automated insertion assembly includes a first dermal perforation assembly configured to releasably engage a first subdermal device. A first actuation assembly is configured to drive the first dermal perforation assembly into a user's skin to a first depth and drive the first subdermal device into the user's skin to a second depth. The second depth is greater than the first depth.

A patch-sized fluid delivery device may include a reusable portion and a disposable portion. The disposable portion may include components that come into contact with the fluid, while the reusable portion may include only components that do not come into contact with the fluid. Redundant systems, such as redundant controllers, power sources, motor actuators, and alarms, may be provided. Alternatively or additionally, certain components can be multi-functional, such a microphones and loudspeakers that may be used for both acoustic volume sensing and for other functions and a coil that may be used as both an inductive coupler for a battery recharger and an antenna for a wireless transceiver. Various types of network interfaces may be provided in order to allow for remote control and monitoring of the device.

An apparatus for determining the volume of fluid dispensed. The apparatus has an acoustic volume sensor that acoustically excites a reference volume and a measurement chamber with a loudspeaker and measures the acoustic response with microphones acoustically coupled to the reference and the measurement chamber. The loudspeaker and sensing microphones are connected to the measurement chamber by separate ports. A detachable dispensing chamber is coupled to the acoustic volume sensor. The volume of the fluid dispensed is determined by a processor based on the acoustic response of the microphones to acoustic excitement by the loudspeaker.