The present disclosure provides advantageous post and partition assembly that is configured and adapted to promote modularity and withstand the harsh environment of central sterile processing processes. Modular post assembly may be removed and relocated on tray without additional fasteners or components. Tray and bracket assembly may further provide identification features to correctly associate cataloged reusable medical devices to identified trays.

Disclosed is a stent-mesh and microelectrode assembly that is deployable using a catheter or cannula to form a neural interface for recording and/or stimulation of neural tissue. In some embodiments, the assembly may include a thin-film microelectrode array attached to a spring-like stent-mesh component. The thin-film microelectrode array may include an electrode body having two lateral wing-like appendages located distal to a thin-film flexible cable that terminates at the proximal end in a thin-film connector region. The stent-mesh may be attached to the thin-film microelectrode array and configured to be advanced to a target area in a collapsed state and then expanded after reaching the target area to transition the thin-film microelectrode array to a deployed configuration. Accordingly, the assembly may deliver the thin-film microelectrode array to a target area in a minimally invasive manner.

Disclosed is a stent-mesh and microelectrode assembly that is deployable using a catheter or cannula to form a neural interface for recording and/or stimulation of neural tissue. In some embodiments, the assembly may include a thin-film microelectrode array attached to a spring-like stent-mesh component. The thin-film microelectrode array may include an electrode body having two lateral wing-like appendages located distal to a thin-film flexible cable that terminates at the proximal end in a thin-film connector region. The stent-mesh may be attached to the thin-film microelectrode array and configured to be advanced to a target area in a collapsed state and then expanded after reaching the target area to transition the thin-film microelectrode array to a deployed configuration. Accordingly, the assembly may deliver the thin-film microelectrode array to a target area in a minimally invasive manner.

Methods, systems, and compositions are provided for implanting an implantable device into a biological tissue (e.g., muscle, brain). A subject implantable device includes: (i) a biocompatible substrate, (ii) a conduit (e.g., an electrode, a waveguide) that is disposed on the biocompatible substrate, and (iii) an engagement feature (e.g., a loop) for reversible engagement with an insertion needle. The biocompatible substrate can be flexible (e.g., can include polyimide). The implantable device is implanted using an insertion needle that includes an engagement feature corresponding to the engagement feature of the implantable device. To implant, an implantable device is reversibly engaged with an insertion needle, the device-loaded insertion needle is inserted into a biological tissue (e.g., to a desired depth), and the insertion needle is retracted, thereby disengaging the implantable device from the insertion needle and allowing the implantable device to remain implanted in the biological tissue.

A universal low-profile intercranial assembly includes a mounting plate and a low profile intercranial device composed of a static cranial implant and an interdigitating functional neurosurgical implant. The low profile intercranial device is shaped and dimensioned for mounted to the mounting plate.

Intraoral electronic sensing for health monitoring is disclosed. Wireless connectivity is provided between a processor and a wireless transmitting device. The wireless transmitting device is embedded in an intraoral sensing interface for use in a person. Sensors are coupled to the wireless transmitting device, wherein the sensors are attached to the intraoral sensing interface. The sensors include a photoplethysmography (PPG) sensor to detect cardiac activity, a breathing sensor to detect pulmonary function, an inertial measurement unit (IMU) sensor to detect three-dimensional motion, and a temperature sensor to monitor body temperature. Further sensors include an electroencephalogram sensor to detect brain activity. Health data about the person is provided to a receiving device, based on data from one or more of the PPG sensor, the breathing sensor, the IMU sensor, and the temperature sensor. The health data is provided using the wireless connectivity.

Intraoral electronic sensing for health monitoring is disclosed. Wireless connectivity is provided between a processor and a wireless transmitting device. The wireless transmitting device is embedded in an intraoral sensing interface for use in a person. Sensors are coupled to the wireless transmitting device, wherein the sensors are attached to the intraoral sensing interface. The sensors include a photoplethysmography (PPG) sensor to detect cardiac activity, a breathing sensor to detect pulmonary function, an inertial measurement unit (IMU) sensor to detect three-dimensional motion, and a temperature sensor to monitor body temperature. Further sensors include an electroencephalogram sensor to detect brain activity. Health data about the person is provided to a receiving device, based on data from one or more of the PPG sensor, the breathing sensor, the IMU sensor, and the temperature sensor. The health data is provided using the wireless connectivity.

A method of neurostimulation includes applying a probe signal to an electrode implanted in or near a target neural structure of the brain. The method further includes detecting a first response from the target neural structure evoked by the probe signal and determining a first time period between application of the probe signal and a first temporal feature of the response. Further, the method includes generating a therapeutic signal comprising a plurality of pulses, at least two of the plurality of pulses separated by the first time period, and applying the therapeutic signal to the electrode or another electrode implanted in or near the target neural structure.

An implantable array, such as an electrode array, is provided. The array is suitable for being placed in anatomic tissue of a human or animal body, and has a structure for referencing predefined distinct points of the implantable electrode array in magnetic resonance images. A structure is arranged in a predefined portion of the implantable array, where the structure has multiple patterns, each pattern having a predefined form and formed from a material having a magnetic susceptibility which is different from the magnetic susceptibility of the anatomic tissue surrounding the implantable array when placed in the human or animal body. Each pattern is in a predefined spatial relationship with one of the predefined distinct points.

An implantable array, such as an electrode array, is provided. The array is suitable for being placed in anatomic tissue of a human or animal body, and has a structure for referencing predefined distinct points of the implantable electrode array in magnetic resonance images. A structure is arranged in a predefined portion of the implantable array, where the structure has multiple patterns, each pattern having a predefined form and formed from a material having a magnetic susceptibility which is different from the magnetic susceptibility of the anatomic tissue surrounding the implantable array when placed in the human or animal body. Each pattern is in a predefined spatial relationship with one of the predefined distinct points.