A method for delivering electrical stimulation to alter a cognitive state of a user, the method comprising: monitoring a brain signal from the user via one or more intracranial electrodes implanted in the brain of the user while the user is presented with a stimulus; comparing the brain signal to a testing phase biomarker, wherein the testing phase biomarker is derived from a cognitive test performed on a contributor during a testing phase; delivering electrical stimulation to a brain of the user based on the comparing step to steer the brain of the user towards a high performance cognitive state.

An automated EP analysis apparatus for monitoring, detecting and identifying changes (adverse or recovering) to a physiological system generating the analyzed EPs, wherein the apparatus is adapted to characterize and classify EPs and create alerts of changes (adverse or recovering) to the physiological systems generating the EPs if the acquired EP waveforms change significantly in latency, amplitude or morphology.

The systems and methods described herein include an external base station with a tethered transceiver, an implanted hub that includes power, telemetry, and processing electronics, and a plurality of implanted satellite that contain reconfigurable front-end electronics for interfacing with electrodes. The system can operate in different modes. In a first mode, called a base boost mode, the external base station is used for closed-loop control of stimulation therapies. In a second, autonomous mode, closed-loop control is performed in the hub without direct influence from the base station. In a third mode, streams of neural data are transmitted to an offline processor for offline analysis.

A system for improving cognitive function is disclosed. The system comprises a non-invasive brain stimulation device (150); a human computer interface; and a computer (101) configured to control the non-invasive brain stimulation device (150) and the human computer interface. The computer (101) controls the brain stimulation device (150) and the human computer interface to assess a subject's baseline cognitive function by interaction with the subject using the human computer interface. If the subject's baseline cognitive function is impaired, the computer (101) uses the human computer interface to provide the subject with a strategy for improving performance in a cognitive function test and stimulates the subjects brain with the non-invasive brain stimulation device (150) while training the subjects cognitive function.

A system for improving cognitive function is disclosed. The system comprises a non-invasive brain stimulation device (150); a human computer interface; and a computer (101) configured to control the non-invasive brain stimulation device (150) and the human computer interface. The computer (101) controls the brain stimulation device (150) and the human computer interface to assess a subject's baseline cognitive function by interaction with the subject using the human computer interface. If the subject's baseline cognitive function is impaired, the computer (101) uses the human computer interface to provide the subject with a strategy for improving performance in a cognitive function test and stimulates the subjects brain with the non-invasive brain stimulation device (150) while training the subjects cognitive function.

A system for evaluating neurologic dysfunction of a subject includes an odorant generator configured to deliver an odorant stimulation to the subject, an auditory generator configured to deliver an audible stimulation to the subject, a vibrotactile stimulator configured to generate a somatosensory stimulation to the subject, a plurality of electrodes configured to be attached to the subject at respective different locations, and at least one processor. The plurality of electrodes are configured to collect neural signals from the subject as a result of the odorant stimulation, the audible stimulation, and the somatosensory stimulation. The at least one processor is configured to process the neural signals from the plurality of electrodes and generate an assessment of neurologic dysfunction of the subject.

Provided is an intraesophageal electrostimulator configured so that other medical tools can also be easily inserted into an esophagus and misalignment in the esophagus can be reduced. An intraesophageal electrostimulator 100 includes a stimulator body 101, stimulating electrodes 111, 112, and power feed lines 113, 114. The stimulator body 101 is formed, in order to insert the stimulator body 101 into an esophagus S, in an elongated flat plate shape with flexibility in a longitudinal direction. The stimulator body 101 includes a first flat plate member 102, a second flat plate member 103, and an exterior body 104. On one plate surface of the first flat plate member 102, each of the stimulating electrodes 111, 112 is provided so as to protrude from the plate surface. The second flat plate member 103 overlaps with the other plate surface of the first flat plate member 102 such that the second flat plate member 103 and the first flat plate member 102 sandwich the power feed lines 113, 114. The exterior body 104 covers the first flat plate member 102 and the second flat plate member 103 overlapping with each other.

A method for delivering electrical stimulation to alter a cognitive state of a user, the method comprising: monitoring a brain signal from the user via one or more intracranial electrodes implanted in the brain of the user while the user is presented with a stimulus; comparing the brain signal to a testing phase biomarker, wherein the testing phase biomarker is derived from a cognitive test performed on a contributor during a testing phase; delivering electrical stimulation to a brain of the user based on the comparing step to steer the brain of the user towards a high performance cognitive state.

A method for graphically displaying evoked potentials is disclosed herein. The method transforms each of an averaged evoked potentials into a single vertical line, wherein a first amplitude range is represented by a first color, a second amplitude range is represented by a second color, a third amplitude range is represented by a third color and a fourth amplitude range is represented by a fourth color.

A diagnostic system includes an array of electrodes, which are coupled to a body surface of a living subject at different, respective positions in proximity to a region of interest within the body. A switched impedance network applies varying loads to the electrodes. A processor is coupled to receive and measure electrical signals from the electrodes as a function of the varying loads, and to analyze the measured signals so as to compute a local electrical characteristic of one or more locations within the region of interest.