A system provides a burr hole cap assembly configured to secure a position of a lead implanted through a burr hole in a cranium of a patient. One or more electrodes are coupled to one or more components of the burr hole cap assembly. The one or more electrode is disposed within the burr hole cap assembly for sensing signals within a brain of the patient or stimulating a portion of the brain of the patient.

A system having one or more devices (1) for automatic brainwave analysis, configured to be worn by a user, and a remote processing unit configured to store all of the signals from said one or more devices, having at least one brainwave sensor (11, 12), providing a stream (21, 22) of brain data associated with said user; at least one environmental sensor (13, 14), providing an environmental data stream (23, 24); means (15) for selecting a signal extracted from said stream of brain data, for associating them with at least one corresponding signal extracted from said stream of environmental data, for storing said signals and for transmitting them to the remote processing unit, the latter comprising means for extracting classification information from said data, and for constituting a set associating said data with the extracted classification information.

A therapeutic or diagnostic device comprises a wearable electrodes garment including electrodes disposed to contact skin when the wearable electrodes garment is worn, and an electronic controller operatively connected with the electrodes. The electronic controller is programmed to perform a method including: receiving surface electromyography (EMG) signals via the electrodes and extracting one or more motor unit (MU) action potentials from the surface EMG signals. The method may further include identifying an intended movement based at least on features representing the one or more extracted MU action potentials and delivering functional electrical stimulation (FES) effective to implement the intended movement via the electrodes of the wearable electrodes garment. The method may further include generating a patient performance report based at least on a comparison of features representing the one or more extracted MU action potentials and features representing expected and/or baseline MU action potentials for a known intended movement.

The present application provides for use of a somatosensory evoked potential (SEP) during the hyperacute stroke phase as marker for predicting the outcome of endovascular treatment in a patient suffering from acute ischemic stroke, wherein when the SEP ipsilateral to the stroke site has an amplitude from 60% to 100% with respect to the corresponding SEP contralateral to the stroke site this is indicative of good outcome of the endovascular treatment, whereas when the SEP ipsilateral to the stroke site has an amplitude from 0% to 20% with respect to the corresponding SEP contralateral to the stroke site this is indicative of bad outcome of the endovascular treatment.

Apparatus and methods are described including driving a coil to apply a magnetic stimulation to a subject's brain, and receiving a magnetic-stimulation-evoked-potential signal from electrodes that are placed in contact with the subject's head. A slope of a late portion of a curve of the magnetic-stimulation-evoked-potential signal is measured. At least partially in response to detecting an indication that the slope of the late portion of the curve of the magnetic-stimulation-evoked-potential signal is below a given threshold, an output is generated that is indicative of the subject being at risk of dementia. Other applications are also described.

Apparatus and methods are described including driving a coil to apply a magnetic stimulation to a subject's brain, and receiving a magnetic-stimulation-evoked-potential signal from electrodes that are placed in contact with the subject's head. A slope of a late portion of a curve of the magnetic-stimulation-evoked-potential signal is measured. At least partially in response to detecting an indication that the slope of the late portion of the curve of the magnetic-stimulation-evoked-potential signal is below a given threshold, an output is generated that is indicative of the subject being at risk of dementia. Other applications are also described.

An example of a neurostimulation system may include a stimulation output circuit to deliver neurostimulation to evoke responses from a patient using an evoking configuration, a sensing input circuit to sense one or more signals including the evoked responses using a recording configuration, and a control circuit. The control circuit may be configured to control the delivery of the neurostimulation using stimulation parameters including the evoking configuration, to control the sensing of the evoked responses using sensing parameters including the recording configuration, and to determine an evoking-recording parameter set by evaluating a sequence of evoking-recording parameter sets. The evoking-recording parameter set may include a set of the stimulation parameters suitable for controlling the stimulation output circuit to deliver the neurostimulation to evoke a target response and a set of the sensing parameters suitable for controlling the sensing input circuit to record the evoked target response.

An example of a neurostimulation system may include a stimulation output circuit to deliver neurostimulation to evoke responses from a patient using an evoking configuration, a sensing input circuit to sense one or more signals including the evoked responses using a recording configuration, and a control circuit. The control circuit may be configured to control the delivery of the neurostimulation using stimulation parameters including the evoking configuration, to control the sensing of the evoked responses using sensing parameters including the recording configuration, and to determine an evoking-recording parameter set by evaluating a sequence of evoking-recording parameter sets. The evoking-recording parameter set may include a set of the stimulation parameters suitable for controlling the stimulation output circuit to deliver the neurostimulation to evoke a target response and a set of the sensing parameters suitable for controlling the sensing input circuit to record the evoked target response.

Systems and methods for evaluating neurologic function of a subject are described. An odorant, auditory and/or somatosensory generator is configured to deliver a sensory stimulation to the subject, a plurality of electrodes are configured to be attached to the subject, and a handheld EEG control unit is configured to control the odorant, auditory and/or somatosensory generator, process the neural signals from the plurality of electrodes and generate an assessment of neurologic function of the subject.

In some embodiments, a method of increasing cognitive function and/or treating a disease or disorder associated with decreased cognitive function in a subject is provided. Treating a subject with an glutamate receptor agonist can include identifying the subject as an glutamate receptor agonist responder. The method can further include obtaining an electroencephalogram (EEG) signals from the subject. The method can further include measuring one or more EEG metrics, thereby identifying the subject as a glutamate receptor agonist. Further provided non-transitory processor-readable medium storing code with instructions for identify glutamate receptor agonist responders