There is disclosed a system for implementing a stimulation protocol that, when in operation, mimics an effect of at least one drug on the brain of a user under treatment for a disease, or for mental well-being applications, wherein the system comprises: (i) a brain interfacing apparatus that records electroencephalogram (EEG) of the user before and after taking the drug; and provides at least one stimulation to the brain of the user, wherein the at least one stimulation is provided to achieve the effect similar to the at least one drug; and (ii) a monitoring device that enables the user to monitor the at least one stimulation provided to the brain of the user by the brain interfacing apparatus, wherein the monitoring device is communicably coupled with the brain interfacing apparatus.

A system and method for brainwave stimulation using altered natural stimuli is provided. The system may comprise a control module and a natural stimulus modulator and is configured to alter at least one natural stimulus signal with frequencies configured to induce brainwave stimulation especially in the range effective for Alzheimer's and other neurological pathologies. The system is configured to prolonged use such that subjects are not prohibited from participation in daily activities and therefore the brainwave stimulation is sufficiently prolonged for enhanced effectiveness. The method for brainwave stimulation may comprise the steps of applying alterations to and delivering at least one natural stimulus signal, measuring brainwave signals and adjusting the alterations accordingly.

A neural analysis and treatment system includes a computing device with a memory for storing an application that is executable on a processor to receive amplitude-integrated electroencephalography (aEEG) and range-EEG (rEEG) measurements associated with a patient. The systems determine a spectral edge frequency (SEF) measurement from the received EEG measurements, and determine one or more neural characteristics of the patient according to the determined SEF, aEEG, and rEEG measurements. These neural characteristics may then be used to identify and implement an appropriate therapeutic treatment.

A neural analysis and treatment system includes a computing device with a memory for storing an application that is executable on a processor to receive amplitude-integrated electroencephalography (aEEG) and range-EEG (rEEG) measurements associated with a patient. The systems determine a spectral edge frequency (SEF) measurement from the received EEG measurements, and determine one or more neural characteristics of the patient according to the determined SEF, aEEG, and rEEG measurements. These neural characteristics may then be used to identify and implement an appropriate therapeutic treatment.

Systems and Methods for Monitoring Neural Activity A method of monitoring neural activity responsive to a stimulus in a brain or a subject under general anaesthetic, the method comprising: applying the stimulus to one or more of at least one electrode implanted in a target neural structure of the brain; detecting a resonant response from the target neural structure evoked by the stimulus at one or more of the at least one electrode in or near the target neural structure of the brain; and determining one or more waveform characteristics of the detected resonant response.

Methods and systems for providing closed loop control of stimulation provided by an implantable stimulator device are disclosed herein. The disclosed methods and systems use a neural feature prediction model to predict a neural feature, which is used as a feedback control variable for adjusting stimulation. The predicted neural feature is determined based on one or more stimulation artifact features. The disclosed methods and systems can be used to provide closed loop feedback in situations, such as sub-perception therapy, when neural features cannot be readily directly measured.

An apparatus and method for non-invasive determination of airway resistance for the detection of pulmonary airway disease includes providing an apparatus and method wherein changes in a pulsatile blood pressure waveform are detected by PhotoPlethysmoGram (PPG) or Ballistography (BSG) and are automatically determined to reflect decreases in airflow and changes in airway resistance.

An apparatus and method for early detection of dementia overcomes the shortcomings of conventional systems and methods for detecting dementia. This is achieved by providing an apparatus and method for employing an early dementia biomarker based on the response to sensory stimulation during sleep, such as during non-rapid eye movement (NREM) sleep.

An apparatus and method for early detection of dementia overcomes the shortcomings of conventional systems and methods for detecting dementia. This is achieved by providing an apparatus and method for employing an early dementia biomarker based on the response to sensory stimulation during sleep, such as during non-rapid eye movement (NREM) sleep.

An apparatus and method for employing the macro- and micro-structure of sleep and similar states of consciousness to optimize pain-treatment are disclosed wherein an objective biomarker of pain-related sleep disturbance guides pain treatment from a sleep perspective. Furthermore, this concept can be extended to states of reduced consciousness such as coma or sedation. Additionally, it could be applied on individuals who are non-communicative due to injury, disease, language issues and/or infancy.