Methods and devices for implanting an intra-ocular pressure sensor within an eye of a patient are provided herein. Methods include penetrating a conjunctiva and sclera with a distal tip of a fluid-filled syringe and positioning the pressure sensor within a vitreous body of the eye by injecting the sensor device through the distal tip. The sensor device may be stabilized by one or more anchoring members engaged with the sclera so that the pressure sensor of the sensor device remains within the vitreous body. Methods further include advancing a sensor device having a distal penetrating tip through at least a portion of the sclera to position the sensor within the vitreous body and extracting of the sensor devices described herein by proximally retracting the sensor device using an extraction feature of the sensor device.

A system and method for assessing blood flow include: an ocular lens; a light source; a digital video camera; a biosensor; a trigger; and a computer. The ocular lens is for viewing a fundus of an eye. The light source is for illuminating the fundus. The digital video camera is for imaging the fundus. The biosensor is for sensing a pulse waveform. The computer is configured for: recording input frames and pulse waveform data in response to an input from the trigger; defining a low-pass frequency and a high-pass frequency from the pulse waveform data; stabilizing the input frames; enhancing contrast of the input frames; separating the input frames into sub-channels; conducting eulerian video magnification for color amplification using the inputs of image sampling rate, the low-pass frequency, the high-pass frequency, and an amplification factor; reconstructing the sub-channels into output frames; and combining the output frames with the input frames.

The present disclosure provides an optical palpation device for evaluating a mechanical property of a sample material. The device comprises a body having a sensing portion and a sensing layer positioned at the sensing portion of the body and having a sensing surface positioned for direct or indirect contact with a surface area of the sample material. The sensing layer is deformable and has a predetermined deformation-dependent optical property. The device further comprises a light detector positioned to detect light transmitted through at least a portion of the sensing layer. The optical palpation device is arranged such that, when the sensing surface of the sensing layer is in direct or indirect contact with the surface area of the sample material and a pressure is applied through both the sensing layer and at least a portion of the surface area of the sample material, because of the predetermined deformation or pressure-dependent optical property of the sensing layer the mechanical property of the sample material is measurable by detecting the light that transmitted through at least a portion of the sensing layer.

An eye-mountable device includes layer(s) of polymer material defining a body. The body includes a first side and a second side extending from a first end to a second end. The first side opposes the second side and curves inwardly toward the second side. The second side curves outwardly away from the first side. The body includes an anterior surface and a posterior surface extending from the first side to the second side and from the first end to the second end. The anterior side opposes the posterior side. The posterior surface has a concave shape. The device includes a substrate in the body including a mounting platform disposed proximally to a middle of the second side. The device includes, on the mounting platform, electronics that interact with a biological environment and monitor health-related information. The body may have a thickness profile that prevents the device from undesired movement.

A method is provided that includes discriminating an autofluorescence (AF) response of a lens tissue of an eye due to a current level of 2-(2-furoyl)-4(5)-furanyl-1H-imidazole (FFI) in the lens tissue by interrogating a lens tissue of an eye along a visual axis of the eye by activating an illuminator for a select time to produce interrogating irradiation having a peak wavelength of 425 nm to 460 nm, the illuminator comprising at least one light source and a focal lens positioned with respect to the light source. The method also includes obtaining at least one image of the autofluorescence response of the lens tissue from a detector, the detector including a digital camera unit, analyzing the at least one image to determine a total autofluorescence index of the lens tissue, and determining a current level of FFI in the lens tissue based, at least in part, on the total autofluorescence index.

A material, article, system and method include a probe composition that includes a hydrophobic portion, a hydrophilic portion, an analyte-binding portion and a fluorophore portion. The analyte-binding portion is configured to bind to an analyte in an aqueous solution. The fluorophore portion is configured to change an optical property of fluorescent light emitted in response to incident excitation light when the probe composition changes between a first state in which the analyte is not bound to the analyte-binding portion and a second state in which the analyte binds to the analyte-binding portion. A material includes the probe composition and a silicone hydrogel substrate having a hydrogel network that allows flow of aqueous solution through the solution and a silicone network that occupies interstices of the hydrogel network. A contact lens having the material enables remote detection of glucose concentration in tear fluid of a subject.

Systems and methods for non-invasively assessing ciliary muscle accommodative potential in phakic eyes may include receiving a plurality of signals generated by a plurality of bipolar electrodes during a ciliary muscle assessment procedure, each of the plurality of signals indicating an electrical field associated with a patient's ciliary muscle, and analyzing the signals to evaluate the patient's ciliary muscle accommodative potential.

An implantable intraocular physiological sensor for measuring intraocular pressure, glucose concentration in the aqueous humor, and other physiological characteristics. The implantable intraocular physiological sensor may be at least partially powered by a fuel cell, such as an electrochemical glucose fuel cell. The implantable intraocular physiological sensor may wirelessly transmit measurements to an external device. In addition, the implantable intraocular physiological sensor may incorporate aqueous drainage and/or drug delivery features.

A patient monitor capable of measuring microcirculation at a tissue site includes a light source, a beam splitter, a photodetector and a patient monitor. Light emitted from the light source is split into a reference arm and a sample arm. The light in the sample arm is directed at a tissue site, such as an eyelid. The reflected light from the tissue site is interfered with the light from the reference arm. The photodetector measures the interference of the light from both the sample arm and the reference arm. The patient monitor uses the measurements from the photodetector to calculate the oxygen saturation at the tissue site and monitor the microcirculation at the tissue site.

The present invention provides reagents and methods for modulating cone photoreceptor activity, and devices for assessment of cone photoreceptor activity.