Glaucoma is the second most common cause of blindness in the global world. It is a multifactorial disease with several risk factors, of which intraocular pressure (IOP) is the most important. IOP measurements are used for glaucoma diagnosis and patient monitoring. IOP has wide diurnal fluctuation, and is dependent on body posture, so the occasional measurements done by the eye care expert in clinic can be misleading. We provide an implantable sensor, based on microfluidic principles, which in one example has 1 mmHg limit of detection, high sensitivity and excellent reproducibility. This sensor has an optical interface, which enables IOP to be read with, for example, a cell phone camera. The design, fabrication, along with the option of self-monitoring are promising steps toward better patient care and treatment for this devastating disease.

A device (100) for measuring ocular microtremor (OMT) of a patient's eye, comprises a light source (10) for illuminating a target area of the eye with a light beam. The device also comprises a detector (20) arranged to detect scattered light from the interaction of the light beam with the target area of the eye. The device further comprises a focusing lens (30) arranged to collect the scattered light for the detector, and a port in a wall of the device through which the light beam can exit the device and/or through which the scattered light can enter the device. The device is configured to stabilise and/or support the device on or against a patients head. A method of measuring microtremor of an eye is also provided.

This disclosure relates to diagnostic imaging of a retina of a patient with diabetic retinopathy. A processor retrieves a first image of the retina captured at a first point in time and a second image of the retina captured at a second point in time after the first point in time. The processor aligns the first image to the second image to reduce an offset between non-pathologic retina features in the first image and the second image and obtains image objects related to diabetic retinopathy in the first image and the second image. The processor then calculates a numerical pathology score indicative of a progression of the diabetic retinopathy by calculating a degree of change of the image objects related to diabetic retinopathy between the aligned first and second images and finally, creates an output representing the calculated numerical pathology score.

One aspect of the invention provides a method of measuring brain state. The method includes: receiving a first plurality of electrical signals from a contact lens placed on a surface of a subject's eye, the first plurality of electrical signals associated with a first plurality of electrodes lying adjacent to an iris dilator muscle of the subject's eye. Another aspect of the invention provides a contact lens including: an optically transparent or translucent substrate; and one or more pairs of electromyography electrodes arranged on or within the optically transparent or translucent substrate. At least one of the one or more pairs electromyography electrodes are arranged to lie adjacent to an iris dilator muscle of a subject's eye when the contact lens is placed on the eye.

Fracture-induced composite sensors and methods of their fabrication are disclosed. The sensors can be used as strain sensors, piezo-resistive sensors, piezo-capacitive sensors, and non-contact displacement wearable sensors.

A surveillance wireless contact lens powered by body fluids for animals and fowls is disclosed using Wi-Fi, Bluetooth®, wireless local area network (WLAN), satellite and cellular tower and radio communication network. The contact lens comprises a molten material, which is injected into a mold cavity through under pressure for making the lens. The contact lens has a central optic portion with a concavo-convex shape, wherein the central optic portion having a depression at the center. A peripheral bearing portion is extended from and about the central optic portion and having an outer margin, which is placed within the limbus of an eye of the animal and/or fowl and opposite the white outer layer of the eyeball. The contact lens further comprises a processor disposed on the peripheral bearing portion, configured to control the operation of the contact lens via an electrical circuit. The electrical circuit in communication with the processor is configured to connect to electronic components include a power source, a light sensor, a communication module, and a camera.

A method for determining a design of a progressive lens intended to be worn by a future wearer, the progressive lens comprising a front surface and a back surface, at least one of the front surface and the back surface comprising a progression profile on its general spherical shape, said at least one progression profile defining a meridian line extending from a distance-vision point to a near-vision point, said meridian line comprising a vertical portion passing through the distance-vision point and an inclined portion passing through the near-vision point, the vertical portion and the inclined portion forming an angle between them, the method including obtaining first data representative of a first measurement of a first postural instability of the future wearer when seeing a visual pattern moving along an mediolateral direction, and determining a reparation between the first progression profile and the second progression profile based on the first data.

A mobile device includes one or more spectrometers, each with a plurality of spectral filters overlaying optical sensors, each of the one or more spectrometers having a sensing range within a predetermined range of optical wavelengths. Each of the one or more spectrometers is further positioned in the mobile device to capture light radiation incident to the mobile device and output information representative of captured light radiation to a processing module adapted to receive the output information and determine an accumulated light radiation for the mobile device. A notification engine is adapted to signal a user when the accumulated light radiation exceeds a predetermined threshold.

The present disclosure provides electroretinography devices configured to detect biopotential signals from an eye of a subject. In some embodiments, the device is configured to prevent the subject's eyelids from closing over the device when placed in contact with the anterior surface of the subject's eye. In some embodiments, the device has a Young's modulus of no more than about 50 MPa. In some embodiments, the device includes a diffusing or refracting element configured to scatter, focus or diverge incident light. In other embodiments, the device includes a void through which incident light can enter the subject's eye without passing through any portion of the device.

The present disclosure relates to a method and a system for imaging a biological tissue. A monochromatic image of the biological tissue is obtained. A texture analysis of the biological tissue is performed using spatial information of the monochromatic image to identity features of the biological tissue. A texture image is generated based on the features of the biological tissue. The biological tissue of the subject is classified as normal or abnormal at least in part based on a comparison between first order statistics of the texture image and predetermined values.