A system includes a processor and a display. The processor is configured to: (a) receive an optical image of an organ of a patient, (b) receive an anatomical image of the organ, (c) receive, from a position tracking system (PTS), a position signal indicative of a position of a medical instrument treating the organ, (d) register the optical image and the anatomical image in a common coordinate system, and (e) estimate the position of the medical instrument in at least one of the optical image and the anatomical image. The display is configured to visualize the medical instrument overlaid on at least one of the optical image and the anatomical image.

A location pad includes two or more field-generators, and a frame. The field-generators are configured to generate respective magnetic fields at least in a region-of-interest (ROI) of a patient organ, for measuring a position of a medical instrument in the ROI. The frame is coupled with tissue that is at least partially surrounding the organ and is configured to fix the two or more field-generators at respective positions surrounding the ROI.

A location pad includes two or more field-generators, one or more tracking elements, and a frame. The field-generators are configured to generate respective magnetic fields at least in a region-of-interest (ROI) of an organ of a patient, for measuring a position of a medical instrument in the ROI. The one or more tracking elements are for registering the location pad with the organ. The frame is coupled with tissue that is at least partially surrounding the organ, and the frame is configured to fix (i) the two or more field-generators at respective positions surrounding at least a portion of the ROI, and (ii) the one or more tracking elements at one or more respective predefined positions on the frame.

An automatic system and method for non-invasive imaging and identification of specific ocular structures of the eye and adnexa tissues by synchronous segmentation of visual and infrared images; that can produce spatial temperature profiles within each segmented area of the eye and adnexa; that can track eye and head movement and eye-blinks during the period of measurement to remove artefacts and maintain synchronicity; that can track ocular surface and eye adnexa temperature profiles over time; that can assist in diagnosis of eye disease; that can produce diagnostic indicators for ocular disease diagnosis and study of the eye. The system comprises infrared and visible light cameras for imaging the ocular structures, and a digital signal processing unit for processing the acquired infrared and visible images to output segmentations of the images for identification of different areas of the eye surface, including pupil, cornea, conjunctiva, and eyelids. The system further captures synchronous infrared and visible images from each segmented area of the ocular surface over the time of measurement. A digital signal processing unit processes and analyzes the infrared and visible images to generate descriptive outputs on temporal and spatial changes in the infrared and visible images over the time of measurement, as well as produce diagnostic indicators for ocular disease diagnosis and study of the eye.

An ocular shield for facilitating generation of Visual Evoked Potentials (VEP) is disclosed. The ocular shield may include a body configured to be disposed over an ocular globe of an eye. Further, the body may include an interior surface and an exterior surface. Further, the ocular shield may include at least one light source configured to generate at least one light emission. Further, the at least one light source may be coupled to the body to facilitate transmission of the at least light emission from the interior surface of the body. Further, the ocular shield may include a power source, electrically coupled to the at least one light source, configured to provide electrical energy to the at least one light source. Further, the ocular shield may include a controller configured to control the power source. Further, the controller may be electrically coupled to the power source.

The present invention provides a morphology determining method of corneal topography, including: a parameter obtaining step, based on an original contour line of a cornea of a target subject as the reference, obtaining a relative displacement of each observation point of a contour line of the pressed cornea changed with time from the beginning of pressing the cornea by an external pressure to a predetermined time after the pressing is finished; a conversion step, performing a mathematical function conversion of the above relative displacement with respect to a spatial contour at each observation time point, so as to respectively obtain one or more order vibrational modes representing the contour line of the time points; and a determining step, respectively comparing the one or more order vibrational modes of the cornea of the target subject with a corresponding order vibrational mode of at least one reference cornea, and determining a morphology of the corneal topography of the cornea of the target subject.

Eyelid illumination systems and methods for imaging meibomian glands for meibomian gland analysis are disclosed. In one embodiment, a patient's eyelid is IR trans-illuminated with an infrared (IR) light. A trans-illumination image of the patient's eyelid is captured showing meibomian glands in dark outlined areas, whereas non-gland material is shown in light areas. This provides a high contrast image of the meibomian glands that is X-ray like. The lid trans-illumination image of the meibomian glands can be analyzed to determine to diagnose the meibomian glands in the patient's eyelid. The eyelid may be trans-illuminated by a lid-flipping device configured to grasp and flip the eyelid for imaging the interior surface of the eyelid. Also, an IR surface meibography image of the meibomian glands may also be captured and combined with the trans-illumination image of the meibomian glands to provide a higher contrast image of the meibomian glands.

An ophthalmic device includes an enclosure, an antenna, a sensor system, and a first conductive trace. The ophthalmic device is configured to mount on or in an eye of a user and includes a central region surrounded by a peripheral region. The antenna is disposed within the peripheral region between an outer edge of the ophthalmic device and the central region. The sensor system includes a sensor trace disposed within the peripheral region between the antenna and the central region. The first conductive trace is at least partially disposed between at least one of the antenna and the sensor trace or the central region and the sensor trace.

A surgical image processing apparatus, including circuitry that is configured to perform image recognition on an intraoperative image of an eye. The circuitry is further configured to determine a cross-section for acquiring a tomographic image based on a result of the image recognition.

Various embodiments disclosed relate to contact lens including nanopores. A contact lens can include a nanoporous film including nanopores that are on an inner surface of the contact lens, and a backing lens on the nanoporous film. Various embodiments further include a biomarker-sensing region of the nanoporous film, a drug storage and delivery region of the nanoporous film, or a combination thereof.