The present disclosure provides electroretinography devices configured to detect biopotential signals from an eye of a subject. In some embodiments, the device is configured to prevent the subject's eyelids from closing over the device when placed in contact with the anterior surface of the subject's eye. In some embodiments, the device has a Young's modulus of no more than about 50 MPa. In some embodiments, the device includes a diffusing or refracting element configured to scatter, focus or diverge incident light. In other embodiments, the device includes a void through which incident light can enter the subject's eye without passing through any portion of the device.

Systems, eye-mountable devices, and methods that facilitate chronotherapeutic treatment of primary open-angle glaucoma are provided which enable therapeutic products to be delivered to the eye in a controlled manner only when desired. According to one embodiment, an eye-mountable device comprises a substrate having an eye-mounting surface for positioning on an eye of a patient, a sensor that obtains a plurality of measurements representative of a condition of the eye of the patient over a period of time, a therapeutic agent delivery assembly coupled, and a processor for executing a temporal model of a therapeutic agent delivery in communication with the sensor and the therapeutic agent delivery assembly. The processor receives the plurality of measurements and activates the therapeutic agent delivery assembly to administer a first amount of a drug to the eye of the patient based on the temporal model associated with the plurality of measurements.

Support structures for positioning sensors on a physiologic tunnel for measuring physical, chemical and biological parameters of the body and to produce an action according to the measured value of the parameters. The support structure includes a sensor fitted on the support structures using a special geometry for acquiring continuous and undisturbed data on the physiology of the body. Signals are transmitted to a remote station by wireless transmission such as by electromagnetic waves, radio waves, infrared, sound and the like or by being reported locally by audio or visual transmission. The physical and chemical parameters include brain function, metabolic function, hydrodynamic function, hydration status, levels of chemical compounds in the blood, and the like. The support structure includes patches, clips, eyeglasses, head mounted gear and the like, containing passive or active sensors positioned at the end of the tunnel with sensing systems positioned on and accessing a physiologic tunnel.

A drowsiness warning system is disclosed. Specifically, the drowsiness warning system includes a first sensor unit configured to be mountable on any one of upper eyelids or lower eyelids of a subject being examined under treatment by using treatment equipment, a second sensor unit configured to be mountable on the other one of the upper eyelids or the lower eyelids of the subject being examined, an output unit configured to generate a drowsiness preventing signal for preventing drowsiness of the subject being examined, and

a control unit configured to determine a drowsy state of the subject being examined, based on a distance between the first sensor unit and the second sensor unit, wherein, when the distance is maintained for a predetermined time or more in a state of being shorter than a predetermined distance, the control unit is further configured to determine that the subject being examined is in the drowsy state, and control the output unit to transmit a drowsiness preventing signal to the subject being examined.

Disclosed herein are devices and methods for detecting blood glucose levels in a subject that involve passively quantifying mid-infrared emissions from the eye of the subject.

Systems and methods for non-invasively assessing ciliary muscle accommodative potential in phakic eyes may include receiving a plurality of signals generated by a plurality of bipolar electrodes during a ciliary muscle assessment procedure, each of the plurality of signals indicating an electrical field associated with a patient's ciliary muscle, and analyzing the signals to evaluate the patient's ciliary muscle accommodative potential.

A patient monitor capable of measuring microcirculation at a tissue site includes a light source, a beam splitter, a photodetector and a patient monitor. Light emitted from the light source is split into a reference arm and a sample arm. The light in the sample arm is directed at a tissue site, such as an eyelid. The reflected light from the tissue site is interfered with the light from the reference arm. The photodetector measures the interference of the light from both the sample arm and the reference arm. The patient monitor uses the measurements from the photodetector to calculate the oxygen saturation at the tissue site and monitor the microcirculation at the tissue site.

A three-dimensional display device for displaying a three-dimensional image, including: a gaze point obtaining unit which obtains a position of a gaze point of a viewer; a fusional area determination unit which determines a fusional area where binocular fusion is allowed, based on the obtained position of the gaze point; a correction unit which corrects the three-dimensional image so as to suppress display of an object that is included in the three-dimensional image outside the fusional area; and a display unit which displays the corrected three-dimensional image.

The present invention provides a device for an energizable Ophthalmic Lens with an event coloration mechanism. The event coloration mechanism may color or change color based on some predefined event. For example, a predefined constituent or predefined condition of the tear fluid may be indicative of the predefined event, and the event coloration mechanisms may interact with the tear fluid, accordingly. The event coloration mechanism may provide the energizable functionality of the Ophthalmic Lens in some embodiments. In others, the event coloration mechanism may be passive but may interact and interface with the electrical components of the Ophthalmic Lens, such as, for example, those included within the Media Insert. Event coloration mechanisms may be combined with additional functionalities that may be included in an energizable Ophthalmic Lens.

The present invention relates generally to an ophthalmic device capable of monitoring neural frequencies and correlating the measured frequencies them to specific brain activity/functions. In some embodiments, profiles specific to the user of the ophthalmic device can be pre-programmed to tailor a brain activity/function profiles according to a user. Based on the determined brain activity/function from the correlation, a signal may be generated to provide feedback to the user. The signal may be transmitted to the user in one or more form. For example, the signal may be outputted to a wireless device in wireless communication with the ophthalmic device, and/or through an audible signal projected by an acoustic element, and/or a visual signal projected using a photon emitter, both which may be included in the ophthalmic device.