A biosensor includes a periodic crystalline structure first layer, and an amorphous crystalline structure second layer. The first and second layers are formed from a biocompatible silicone having a Young's Modulus E between 0.4 and 2.0 MPa. The biosensor has a pressure dependent NIR resonance peak shift of less than 15 nm over a field of view of 40°, and has an optical pressure sensitivity of between 0.38 and 2.6 nm/mm Hg. The biosensor may be formed by forming a 3D crystalline structure having a periodic amorphous crystalline first layer and an amorphous crystalline second layer. Voids of the 3D crystalline structure are filled with the biocompatible silicone/polydimethylsiloxane a material. The 3D crystalline structure is removed to form an inverse structure having a first volume of an amorphous arrangement of voids and a second volume of a periodic arrangement of voids.

An eye lens worn on a user's cornea monitors deformations of the cornea. The eye lens includes a substrate and at least one deformation sensor secured to the substrate. The deformation sensor is configured to monitor the curvature of cornea and any deformations, convert the deformations into digital signals, and transmit the digital signals out. A cornea monitoring system using the eye lens is also provided.

A biological signal measurement system includes: a biological signal measurer that measures a biological signal including external noise of biological noise and of environmental noise; biological noise measurer that measures a signal including the biological noise; a biological noise estimator that estimates the biological noise from the signal measured by the biological noise measurer; an environmental noise measurer that measures a signal including the environmental noise; an environmental noise estimator that estimates the environmental noise from the signal measured by the environmental noise measurer; and a calculator that calculates the biological signal in consideration of an effect of the external noise using the signal measured by the biological signal measurer, the biological noise estimated by the biological noise estimator and the environmental noise estimated by the environmental noise estimator.

An eye-mountable device is provided that includes an eyelid occlusion sensor. The eyelid occlusion sensor is used to detect winks, squints, downwards glances or looks, blinks, or other eye-based gestures generated by the user. Based on the detected gestures, an optical power of an adjustable lens of the device may be changed or some other operations could be performed by the eye-mountable device. Such operations could include toggling the optical power of the lens between first and second power levels due to the user squinting, looking downward, or performing some other gesture. Additionally or alternatively, such operations could include setting the optical power of the lens to a first optical power unless the user is looking downward, in which case the optical power of the lens could be set to a second optical power.

The invention provides devices and methods for non-invasive monitoring and measuring of intraocular pressure (IOP) of a subject. Embodiments include a lens that is adapted to fit on the subject's eye, a microstructure disposed in or on the lens, the microstructure having at least one feature that exhibits a change in shape and/or geometry and/or position on the lens in response to a change in curvature of the lens. When the curvature of the lens changes in response to a change in IOP, a corresponding change in shape and/or geometry and/or position of the feature may be used to determine the change in IOP. The change in the feature is detectable in digital images of the lens taken with a mobile electronic device such as a smartphone.

An object of the present technology is to accurately determine a motion sickness state of an individual subject. The present technology provides a motion sickness state determination system (1) that includes a first index acquisition unit (12) that acquires biological information of a subject as a first motion sickness state index, a second index acquisition unit (13) that acquires a second motion sickness state index on the basis of movement information regarding a movement of the subject and/or surrounding environment information perceived by the subject, and a motion sickness state determination unit (14) that determines whether or not the subject will be in a motion sickness state or is in the motion sickness state on the basis of the first motion sickness state index and the second motion sickness state index. Furthermore, the present technology also provides a motion sickness state determination device (10), a biological information acquisition device (20), and a surrounding environment information acquisition device (30) included in the system, and a motion sickness state determination method.

A probe compound, contact lens containing bound probe, and method are disclosed for use in detecting analytes in basal tears on the surface of the eye of a subject. The probe composition preferably includes a hydrophilic portion, an analyte-sensitive portion and a fluorophore portion as well as a hydrophobic portion that allows binding to the contact lens material and optionally can modify the binding affinity of the fluorophore probe. The analyte-sensitive portion is configured to bind to a specific analyte in aqueous solution or to be quenched by the analyte. The fluorophore portion is configured to change an optical property of fluorescent light emitted in response to incident excitation light when the probe composition changes between a first state in which the analyte is not bound to the analyte-binding portion and a second state in which the analyte binds to the analyte-binding portion.

A surgical image processing apparatus, including circuitry that is configured to perform image recognition on an intraoperative image of an eye. The circuitry is further configured to determine a cross-section for acquiring a tomographic image based on a result of the image recognition.

An example method involves: forming a first bio-compatible layer that defines a first side of a bio-compatible device; forming a conductive pattern over a portion of the first bio-compatible layer; mounting an electronic component to the electrical contacts; forming a second bio-compatible layer over the first bio-compatible layer, the electronic component, the conductive pattern, wherein the second bio-compatible layer defines a second side of the bio-compatible device; forming a first etch mask to partially cover the second bio-compatible layer, thereby exposing a first portion of the second bio-compatible layer; removing the first portion of the second bio-compatible layer; forming a second etch mask to partially cover the second bio-compatible layer, thereby exposing a second portion of the second bio-compatible layer; and removing the second portion of the second bio-compatible layer.

Disclosed is a flexible insert (100) for placement on the human eye, comprising a light source (110) in said insert such that light emitted from the light source is shielded from the human eye upon correct placement of the insert on the human eye, a light-responsive material (120) placed in the light path of the light source, said light-responsive material emitting light upon stimulation by the light from said light source, the intensity of said stimulated emission being sensitive to a chemical interaction of the light-sensitive material with an analyte of interest, a photodetector (130) for detecting the light emitted by the light-responsive material; and a transmitter (140) coupled to the photodetector for transmitting a photodetector reading. The insert may be used in conjunction with a reader for automated monitoring of an analyte of interest such as glucose in the tear fluid of its wearer.