The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

A cannula assembly for treating a puncture site in a subcutaneous vessel includes a cannula and an elongated sleeve with a bore for receiving the cannula. The elongated sleeve includes a plurality of channels circumferentially spaced about the bore through which at least one of a flow of air can be drawn and a plurality of wires can be advanced to promote the formation of a seal between the elongated sleeve and the subcutaneous vessel around the puncture site. The cannula assembly can further include a plug which can be inserted into the bore of the elongated sleeve following removal of the cannula. A needle for insertion into the subcutaneous vessel includes a rigid shaft with an enlarged segment connected to a hub. The needle and cannula assembly can be utilized in a method for cannulating the subcutaneous vessel.

An apparatus for medical purposes is disclosed. The apparatus includes a medical device configured to be at least partially insertable into body tissue of a user. It also includes an inserter configured for at least partially inserting the medical device into the body tissue. A housing has a removable cap connected thereto, and the removable cap is removed from the housing before insertion of the medical device. A flexible connector connects the removable cap to the housing, the flexible connector being reversibly displaceable from a locking position in which the removable cap is secured to the housing and a releasing position in which the removable cap is released from the housing. A frangible securing element secures the flexible connector into the locking position prior to use. Further, methods for preparing the apparatus and inserting the medical device into the body tissue of the user are disclosed.

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

A sensor insertion device for inserting a detection element of a sensor configured to measure biological information of a subject into the body of the subject includes a device body; a data process unit attached to the device body, a movement mechanism detachably attached to the device body, the movement mechanism being configured to move the detection element together with an insertion needle configured to be stuck into the body of the subject to insert the detection element and the insertion needle into the body of the subject; and a displacement preventing member.

Electrochemical Impedance Spectroscopy (EIS) is used in conjunction with continuous glucose monitors and continuous glucose monitoring (CGM) to enable in-vivo sensor calibration, gross (sensor) failure analysis, and intelligent sensor diagnostics and fault detection. An equivalent circuit model is defined, and circuit elements are used to characterize sensor behavior.

An inserter for a medical device, where the inserter includes a housing having a first end with an opening therein, an actuator connected to a first gear, an actuator biasing element, a cam gear assembly including a cam member and a second gear, a cam bridge follower in contact with the cam member, and a first plunger assembly having a first plunger and a first biasing element.

A sensor assembly (226) for detecting at least one analyte in a body fluid, a sensor patch (134) for use in a sensor assembly (226), an electronics unit (188) for use in a sensor assembly (226) and a method for producing a sensor assembly (226) are disclosed. The sensor assembly (226) comprises: at least one sensor patch (134), having at least one body mount (136) configured for attachment to a body of a user; and at least one sensor (110) for detecting the at least one analyte in the body fluid, the sensor (110) having at least two electrodes (114) configured for detecting the analyte, the sensor (110) further having at least two sensor contacts (116) for electrically contacting the electrodes (114);  wherein the sensor patch (134) comprises a patch housing (138) with a patch bayonet contour (140); at least one electronics unit (188) attachable to the body mount (136), having at least one electronics component (200) for one or more of controlling the detection of the analyte or transmitting measurement data to another component, wherein the electronics unit (188) further comprises an electronics unit housing (202) having an electronics unit bayonet contour (204);
wherein the patch bayonet contour (140) and the electronics unit bayonet contour (204) in conjunction form a bayonet connector (228) configured for establishing a releasable mechanical connection between the electronics unit (188) and the sensor patch (134).

Methods of determining when to activate an analyte, e.g. glucose, related alarm, such as a hypoglycemia alarm, of a continuous analyte monitor is provided. Also provided are systems, devices and kits.

Some embodiments of the disclosure provide an applicator for applying a medical instrument to a host. In some examples, the applicator includes a housing, an auxiliary mechanism, a first drive mechanism, and a second drive mechanism. The auxiliary mechanism includes a moving body movable with respect to the housing. A receiving portion is provided to the moving body and configured to receive and accommodate the medical instrument. A puncture member is configured to be movable with respect to the receiving portion. The first drive mechanism is configured to act on the moving body toward a proximal end. The second drive mechanism is configured to act on the puncture member toward a distal end. When released, the moving body is driven toward the proximal end by the first drive mechanism to place the medical instrument received in the receiving portion at least partially subcutaneously in the host.