Devices and methods for treatment of a patient's vasculature are described. Embodiments may include a permeable implant having a radially constrained state configured for delivery within a catheter lumen, an expanded state, and a plurality of elongate filaments that are woven together. The permeable implant may include a stiffer proximal portion that is configured to sit at the neck of an aneurysm. The stiffer proximal portion may include coils, stiffening elements, or reinforcement elements disposed about or associated with the filaments or woven together with the filaments.

Devices for occluding an aneurysm are provided. In particular, the device include an upper member that sits against the dome of the aneurysm, a lower member that sits in the neck of the aneurysm, and a means of adjusting the overall dimensions of the device. Also provided are methods of making and using these devices.

A system includes an elongated catheter including a proximal end configured for operative coupling to an electrical power source, a distal end with a first electrical connector and a first conducting wire, an implant including a tissue energising module and a proximal connecting hub configured to detachably couple with the distal end of the elongated catheter. The proximal connecting hub includes a second electrical connector configured to mate with the first electrical connector and electrically couple the first electrical connector with the tissue energising module through a second conducting wire. A latch system to lock the distal end of the catheter to the proximal connecting hub arm includes an arm attached to the distal end of the catheter that is resiliently deformable such that the arm engages a sidewall of the proximal connecting hub and a locking element that is axially adjustable.

A system including an elongated catheter and an implant. The elongated catheter includes a proximal end configured for operative coupling to an electrical supply module, a distal end with a first electrical connector and a first conducting wire to electrically couple the electrical supply module with the first electrical connector. The implant includes a proximal connecting hub configured to detachably mount to the distal end of the elongated catheter, a second electrical connector configured to mate with the first electrical connector, and an active module electrically coupled to the second electrical connector. The first electrical connector is rotatably mounted to the distal end of the elongated catheter and the second electrical connector is non-rotatably attached to the proximal connecting hub of the implant and the elongated catheter can detach from the implant without rotation of the first electrical connector relative to the second electrical connector.

A hydrogel stent for cerebral aneurysm includes a hydrogel polymer, and a stent body wrapping at least a portion of the hydrogel polymer. The stent body is expandable in a cerebral aneurysm of a blood vessel. The stent body is provided in a mesh type surrounding at least a portion of the hydrogel polymers. An embolization device for cerebral aneurysm, includes a hydrogel stent for cerebral aneurysm; a micro-conduit providing a movement path for guiding the hydrogel stent to a cerebral aneurysm of a blood vessel; and a pusher wire connected to the hydrogel stent to be movable in the movement path.

The present invention provides a braided implant with a retractable dual proximal layer and methods for administering the braided implant to treat aneurysms. The implant can include a tubular braid that can be set into a predetermined shape, compressed for delivery through a microcatheter, and implanted in at least one implanted position that is based on the predetermined shape and the geometry of the aneurysm in which the braid is implanted. The implant can also have a retractable dual layer at the proximal end of the device made of the same braid to provide additional coverage at the neck of the aneurysm. The dual layer can be pressed distally into a first implanted portion of the tubular braid, moving the first portion of the tubular braid towards the distal portion of an aneurysm wall so that the implant can partially or completely occlude an aneurysm neck.

A device for occluding a vasculature of a patient including a micrograft having an absorbent polymeric structure with a lumen of transporting blood. The micrograft has a series of peaks and valleys formed by crimping. The occluding device is sufficiently small and flexible to be tracked on a guidewire and/or pushed through a microcatheter to a site within the vasculature of the patient. Delivery systems for delivering the micrografts are also disclosed.

A medical implant including an expandable framework configured to shift between a collapsed configuration and an expanded configuration, the expandable framework comprising a plurality of interconnected struts defining a plurality of cells; and an occlusive element connected to the expandable framework and having an inner surface and an outer surface. The expandable framework may include a plurality of securement members projecting from the plurality of interconnected struts. One of the inner surface or the outer surface of the occlusive element may be in contact with the plurality of interconnected struts, and the other of the inner surface and the outer surface not in contact with the plurality of interconnected struts may lie against an opposing surface of each of the plurality of securement members. A tip portion of the plurality of securement members may not extend radially outward of the plurality of interconnected struts.

Medical devices, systems and methods for occluding a left atrial appendage of a heart. In one embodiment, a medical device system includes a pusher catheter with a medical device coupled adjacent a distal end of the pusher catheter. The medical device includes a primary hub and a secondary hub with a framework extending therebetween, the primary hub including grooves defined therein. The framework is moveable between constricted and expanded positions such that as the framework moves to the constricted position the grooves are configured to align portions of the framework as the secondary hub moves through the bore of the primary hub. In another embodiment, components of the framework may be configured to minimize resistance in the system as the medical device is delivered and moved between the constricted and expanded positions.

A device for permanent placement across an atrial appendage ostium in a patient includes a support structure having a contracted delivery configuration and an expanded deployed configuration defining a radially enlarged portion to permanently engage an interior wall of the atrial appendage, a membrane attached to the support structure and configured to extend across the ostium of the atrial appendage when the support structure is in the expanded deployed configuration, and a polymer coating disposed on at least one of the support structure and the membrane, the polymer coating including a direct oral anticoagulant (DOAC) dispersed in a polymer.