A left atrial appendage closure device may include an expandable framework having a plurality of struts joined at a proximal and distal hub. When the framework is fully constrained in a first position, a first segment of struts extends distally from the distal hub parallel to a central longitudinal axis to a first bend and a second segment of struts extends from the first bend proximally. A first amount of the framework is unconstrained in a second position, where the first segment extends distally from the distal hub parallel to the central longitudinal axis to the first bend, the second segment extends from the first bend proximally and radially outward to a second bend, a third segment of struts extends from the second bend proximally and radially inward to a third bend, and a fourth segment of struts extends from the third bend proximally to within the delivery sheath.

Vaso-occlusive apparatuses, including implants, and methods of using them to treat aneurysms. For example, described herein are expandable vaso-occlusive implants that include one or more soft and expandable braided member coupled to a pushable member such as a coil that maybe inserted and retrieved from within an aneurism using a delivery catheter. In particular, the expandable implants described herein are configured to allow relatively soft and elongate implants to be pushed out of a cannula without binding up within the cannula.

A bristle device for delivery into a body lumen comprises a longitudinally extending stem 1 and a plurality of bristles extending generally outwardly from the stem for anchoring the device in a body lumen. There may be at least two bristle segments and in some cases there are flexible sections between the segments. The flexible sections articulate to enable the device to pass through a catheter placed in a tortuous anatomy or to be deployed in a curved vessel, or across a bifurcation. In some cases at least some of the bristle segments are spaced-apart to accommodate bending of the bristles.

Devices and methods for increasing a patient's pulmonary arterial compliance are disclosed. The devices include catheters designed to create a connection between a patient's venous anatomy and the patient's pulmonary artery. With the arteriovenous connection various devices can be implanted in order to increase the volumetric compliance of the pulmonary artery. The devices include collapsible and expandable mechanisms which allow the effective pulmonary arterial volume to expand during systole and contract during diastole. The devices may include a balloon or balloon-like implants which cyclically shuttle a working fluid from the pulmonary artery to the vein and back. The devices may be adjustable to provide desired hemodynamic benefits. Methods are disclosed for making and using the inventive devices.

A parent artery occlusion (PAO) device which provides for immediate occlusion of a cerebral artery to isolate a defect. The PAO device includes a self-expanding wire-frame prolate structure which is partially covered with an ePTFE membrane.

An occluding device includes a sealing disc. The sealing disc includes a proximal disc surface and a distal disc surface, as well as an edge connecting the proximal disc surface and the distal disc surface. The sealing disc is provided with at least one buffer member. The at least one buffer member is distributed along the edge. The occluding device can reduce the damage inflicted on internal tissues caused by the edge of the sealing disc, better protect the internal tissues and reduce the risk of surgery.

A left atrial appendage occluder comprises an elastic closure disc, and a supporting structure connecting with the closure disc and being located on one side of the closure disc, with the supporting structure comprising a central end connecting with the closure disc and a plurality of interconnected and bent struts, wherein at least one anchoring thorn is set near the end of at least one strut with the anchoring thorn toward the closure disc. The left atrial appendage occluder has a stable structure, a good positioning and sealing effect on the cavity wall in the left atrial appendage, and it is easy to position repeatedly; it can also be recycled before separating from a conveyor. When in surgical operation, the left atrial appendage occluder can select the position area based on the actual shape and size of the patient's left atrial appendage, so the surgical risk is lowered.

A left atrium appendage (LAA) isolator, including: a body sized and shaped to fit an at least partially inverted LAA of a human adult, wherein a distal end of said body defines a two-state sealing adaptor interface configured in a first state to apply a radially outward force against a wall of said LAA or against a wall of said LAA opening sufficient to anchor said body to the LAA wall, and in a second state the sealing adaptor interface is configured to apply a radially inward force on a portion of the inverted LAA positioned within said body.

A device for treating an aneurysm with a braided implant can include a delivery tube having a spiral groove on an outer surface of the delivery tube and a braided implant having a spiral segment. The spiral segment can engage the spiral groove as the braided implant is delivered to an aneurysm treatment site. At the treatment site, the braided implant can be implanted, and the delivery tube can be rotated to disengage the spiral segment from the spiral groove. Once released, the spiral segment can reshape to occlude the neck of the aneurysm.

Vascular remodeling devices can include a proximal section, an intermediate section, and a distal section. During deployment, the proximal section can expand from a compressed delivery state to an expanded state and anchor the device in an afferent vessel of a bifurcation. The distal section expands from the compressed delivery state to an expanded state that may be substantially planar, approximately semi-spherical, umbrella shaped, or reverse umbrella shaped. The distal section is positioned in a bifurcation junction across the neck of an aneurysm or within an aneurysm. The intermediate section allows perfusion to efferent vessels. Before or after the device is in position, embolic material may be used to treat the aneurysm. The distal section can act as a scaffolding to prevent herniation of the embolic material. The device can be used for clot retrieval with integral distal embolic protection.