Medical devices as wells as methods for making and using medical devices are disclosed. An example medical device may include a left atrial appendage device. The left atrial appendage device may include an expandable frame configured to shift between a first configuration and an expanded configuration. A fabric mesh may be disposed along at least a portion of the expandable frame. An anti-thrombogenic coating may be disposed along the fabric mesh.

A device for occluding flow of materials is formed as a simple structure permitting a compact delivery configuration which may shift to an expanded deployment configuration. The device has at least one expandable portion formed of a plurality of elongated longitudinally extending frame elements. The frame elements may be spaced apart to define spaces therebetween, and a flexible occlusive material may be provided to block flow of material through such spaces. A flexible occlusive material may form one of two expandable portions of the device without the need for frame elements.

A device to treat a left atrial appendage (LAA) of a patient includes a tissue ingrowth member, at least one connector, a tine, and a plurality of struts connected to the tissue ingrowth member and at least one connector. A plurality of anchors extends from the tissue ingrowth member proximate the connection point of the struts to the tissue ingrowth member. The device is configured to change shape from a compressed pre-deployment configuration to at least one expanded post-deployment configuration such that the anchors puncture and lodge into cardiac tissue, occluding an ostium of the left atrial appendage.

Devices and methods are described for occluding the left atrial appendage (LAA) to exclude the LAA from blood flow to prevent blood from clotting within the LAA and subsequently embolizing, particularly in patients with atrial fibrillation. An implant is delivered via transcatheter delivery into the LAA. The implant includes a conformable structure comprising a foam body and internal support. The support includes anchors that penetrate the foam body and anchor the implant to the walls of the LAA. The implant provides compliance such that it conforms to the native configuration of the LAA.

This invention is an intrasacular aneurysm occlusion device with nested structures, including an inner embolic structure (e.g. inner mesh, net, braid, and/or stent) which is nested inside an outer embolic structure (e.g. outer mesh, net, braid, and/or stent). The inner embolic structure can have an ellipsoidal, toroidal, inverted jug, or inverted bottle shape. The outer embolic structure can have a spherical shape. The device can also have an opening and valve through which embolic material is inserted into the aneurysm sac.

Devices used to restrict flow within a blood vessel are disclosed. Devices within the scope of this disclosure include a braided lattice of nitinol wires that form self-expanding enclosures of an embolic structure. The devices may further include embolic particles disposed within the enclosures. Methods of deploying the devices with the embolic particles are disclosed. Methods of manufacturing the devices with the embolic particles disposed within the enclosures are disclosed.

The techniques of this disclosure generally relate to a method including navigating an adhesive catheter to a proximal end of a false lumen of a dissection. The false lumen is defined by a septum and a vessel wall. The method further includes delivering an adhesive from the adhesive catheter to the proximal end of the false lumen. The adhesive is compressed between the septum and the vessel wall to close the false lumen.

Medical devices as wells as methods for making and using medical devices are disclosed. An example medical device may include a left atrial appendage device. The left atrial appendage device may include an expandable frame configured to shift between a first configuration and an expanded configuration. A fabric mesh may be disposed along at least a portion of the expandable frame. An anti-thrombogenic coating may be disposed along the fabric mesh.

This intrasacular aneurysm occlusion device includes a neck bridge with a closeable opening through which embolic material is inserted into an aneurysm sac. After the neck bridge has been expanded within the aneurysm sac, a catheter is inserted through the opening and embolic material is delivered through the catheter into the aneurysm sac. After the aneurysm sac has been filled with embolic material, the catheter is then withdrawn and the opening is closed so that embolic material does not escape out of the aneurysm sac.

An implantable device capable of regulating flow of material through a body passage. The implantable device may include at least one retention member having a surface curved to resist migration of the implantable device with respect to the body passage. The implantable device may be provided with features providing a cushioning effect with respect to tissue at which the implantable device is implanted. The length of the implantable device and/or the configuration of at least one retention member on the implantable device may be adjustable. A removal element may be provided to facilitate removal of the implantable device.