Methods and apparatus for accessing and repairing a vertebral disc include a pad with a central cut-out mounted to the skin of a patient or, alternatively, a pedicle-mounted support. An incision is made and then a corridor is created using an elongated guide and a series of dilating tubes. An access to the disc space is created through the superior articular process and the facet joint using the corridor defined by the dilating tubes. Nucleus material is removed from the disc space and the vertebral endplates are prepared. The disc space may be sized to select a suitable implant, which is advanced through the corridor and into the disc space following discectomy and endplate preparation. Bone graft material may be inserted into the disc space following installation of the implant and then posterior rigid fixation may be achieved using percutaneous pedicle screws, followed by closure of the site.

An adjustable spinal stabilization system for maintaining preselected spacing and movement between adjacent vertebrae in a spinal column and for providing overall stability thereto. The system includes at least one interlaminar member positioned in the spaces intermediate a first vertebra and the vertebrae positioned immediately above or immediately below and adjacent to the first vertebra. The interlaminar member is operatively connected to an adjustable support structure and cooperates therewith to maintain the preselected spacing between adjacent vertebrae and to provide overall stability to the spinal column.

Systems, methods, and devices for securing a sublaminar band are provided. A sublaminar band clamp system may include a first locking mechanism, a second locking mechanism, and a body. The body may include a first portion comprising a first passage, wherein the first locking mechanism is disposed within the first passage. The body may further include a second portion comprising a second passage, wherein the second locking mechanism is disposed within the second passage. A third passage may extend across the body and may be in fluid communication with the second passage. An opening may be positioned between the first and second portions, and the opening may be in fluid communication with the first passage.

Systems, methods, and devices for securing a sublaminar band are provided. A sublaminar band clamp system may include a first locking mechanism, a second locking mechanism, and a body. The body may include a first portion comprising a first passage, wherein the first locking mechanism is disposed within the first passage. The body may further include a second portion comprising a second passage, wherein the second locking mechanism is disposed within the second passage. A third passage may extend across the body and may be in fluid communication with the second passage. An opening may be positioned between the first and second portions, and the opening may be in fluid communication with the first passage.

A joint implant system adapted for use in joint surgeries. Among other things, the joint implant has an anterior cutting edge and a rotatable cutter supported by a rotatable shaft.

A spinal implant includes a first member configured to penetrate tissue and a second member. The second member has an abutment engageable with a surgical instrument and at least one peripheral capture element engageable with a moveable arm of the surgical instrument. Systems, spinal constructs, surgical instruments and methods are disclosed.

Embodiments herein are generally directed to spinal implants for use in orthopedic stabilization assemblies. In some embodiments, these implants may be used in conjunction with laminoplasty or laminectomy procedures.

The invention discloses a bionic artificial spinal joint, wherein the spinal joint includes a plurality of fixing units, the fixing units are fixed on a vertebral body, at least two fixing units located on one side of a spine are arranged along the extension direction of the spine and fixed in sequence, and sufficient force can be borne between two adjacent fixing units. The overall micro-motion joint structure formed by two adjacent fixing units is both supportable and bendable. The present application imitates the function of the human inter-process joints, so that the spine equipped with the bionic artificial spine joint can be bent within a certain angle range while maintaining the height of the intervertebral space, thereby avoiding the problem of spinal rigidity after the traditional spine surgery pedicle internal fixation.

A system used for connecting a first implant and a second spinal implant. Among other things, the system includes a connector with a flexible member that allows the connector to be positioned a plurality of angles relative to the first implant.

The present invention is directed to azabicyclo[4.1.0]heptane compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.