A perforated sheath is anchored in a tissue opening with the aid of a tool, wherein the anchorage is achieved with the aid of mechanical vibration and a material which is liquefiable by the vibration. The tool includes a vibrating element and a counter element. Distal portions of both elements are introduced into the sheath to be in contact with each other at an interface. The vibrating element is connected to a vibration source and the vibrating element and the counter element are held against each other for effecting liquefaction of the liquefiable material at the interface. Under the effect of the force applied to the vibrating and counter element for holding them against each other, the liquefied material flows from the interface through the sheath perforation and penetrates the tissue.

A storage and mixing system for pasty two-component polymethyl methacrylate bone cements comprises a tubular cartridge with a cylindrical interior, a cartridge head that closes one end of the tubular cartridge, a partition wall axially disposed in the cylindrical interior and dividing the cylindrical interior into two spatially separate cavities, the first cavity including a first pasty cement component and the second cavity including a second pasty cement component, two delivery plungers disposed movably in the two cavities and connected via a connecting means, wherein a wedge or cone having a cutting edge on the front side thereof facing the cartridge head is disposed on the connecting means, such that said cutting edge cuts open the partition wall when the delivery pistons are advanced towards the cartridge head and the wedge or cone presses the cut open parts of the partition wall towards the inner wall of the cartridge.

Provided herein are settable surgical compositions and methods for their intraoperative use.

The invention provides a system for the preshearing based control of the flow and deformation behavior, i.e., the setting kinetics, and the time dependent shear viscosity, elasticity of aqueous cementitious suspensions that can be used for bone repair and regeneration. The dynamic cement microstructure is tailored to the demands of the surgical tasks (faster/slower setting) or additive manufacturing tasks (lower/higher viscosity) by application of various preshearing conditions. The relationships between the preshearing and pressurization conditions and the setting kinetics and the time dependent changes in elasticity and viscosity are complex and characterization of viscoelastic properties using advanced rheological characterization techniques including small-amplitude oscillatory and steady torsional rheometry is needed a priori to enable such tailoring. The preshearing system is intended to give control on the injectability and setting time of any calcium phosphate cement formulation to the surgeon during an orthopedic surgery where a batch of bone cement is processed. Other possible utilizations of the system include controlling the setting kinetics, shear viscosity and facilitating the resultant flow stability of cementitious ceramic suspensions processed in direct ink writing assemblies for additive manufacturing of cement constructs, in injection systems for restoration and fracking.

The invention provides a system for the preshearing based control of the flow and deformation behavior, i.e., the setting kinetics, and the time dependent shear viscosity, elasticity of aqueous cementitious suspensions that can be used for bone repair and regeneration. The dynamic cement microstructure is tailored to the demands of the surgical tasks (faster/slower setting) or additive manufacturing tasks (lower/higher viscosity) by application of various preshearing conditions. Since the relationships between the preshearing and pressurization conditions and the setting kinetics and the time dependent changes in elasticity and viscosity are complex, a priori characterization of viscoelastic properties using the advanced rheological characterization technique of small-amplitude oscillatory rheometry is needed to enable such tailoring. The preshearing system is intended to give control on the injectability and setting time of any calcium phosphate cement formulation to the surgeon during an orthopedic surgery where a batch of bone cement is processed. Other possible utilizations of the system include controlling the setting kinetics, shear viscosity and facilitating the resultant flow stability of cementitious ceramic suspensions processed in direct ink writing assemblies for additive manufacturing of cement constructs, in injection systems for oil wells, restoration and fracking.

The invention relates a system for implanting an implantable device in bone tissue, a processing unit for such system, a method of implanting an implantable device and a method of providing information for an implanting of an implantable device. In view of the finding that a fat content in cancellous bone is higher than a fat content in compact bone, the lipids fraction, which can be determined by optical means, e.g. spectroscopy, can be used to determine correct screw placement in healthy bone.

A method of regulating a setting time of a bone filler material, the method comprising: (a) combining at least two filler material components to form a biocompatible mixture; (b) choosing a setting time for the mixture; and (c) regulating a temperature of the mixture to influence reaction kinetics so that the mixture does not set before the chosen setting time.

A method of manufacturing a resorbable balloon designed to contain bone cement for vertebroplasty or kyphoplasty applications is described. The resorbable balloon can be inserted into a vertebral body following vertebral cavitation and filled with bone cement. The balloon remains in place in the vertebral body and resorbs over time. Methods and apparatus are also described for delivering therapeutic agents using collapsible, resorbable balloons. The balloons may be nested and filled with various therapeutic agents that are released over time at rates dependent upon structures and degradation rates of the balloons. Furthermore, the function of the hollow devices can encompass both encapsulation and therapeutic substance delivery roles simultaneously.

Systems and methods for indicating an interval in which a procedure (or sub-procedure) should be carried out are disclosed. Some systems and methods involve timing various sub-procedures and alerting a practitioner at the completion of a sub-procedure period. Some systems and methods include a sensor, such as a temperature sensor, that is used determine a window of time in which a variable-viscosity material is of suitable viscosity for delivery to a patient.

Provided herein are settable surgical compositions and methods for their intraoperative use.