A catheter system for pressure wave and inertial impulse generation for intravascular lesion disruption includes a balloon coupled to an elongate shaft, and a first and second light guide disposed along the elongate shaft. The first and second light guides each include a diverting feature in optical communication with at least one light window to direct light to exit each light guide toward a side surface portion thereof and toward the balloon. A method includes expanding the balloon from a collapsed configuration to a first expanded configuration, and activating a light source in optical communication with each light guide to provide sub-millisecond pulses of light to the diverting features, thereby inducing plasma formation in a balloon fluid, causing rapid bubble formation, and imparting pressure waves upon the treatment site.

A catheter system for treating a treatment site within or adjacent to a vessel wall or a heart valve, includes a light source, a balloon, a light guide and an optical analyzer assembly. The light source generates first light energy. The balloon is positionable substantially adjacent to the treatment site. The balloon has a balloon wall that defines a balloon interior that receives a balloon fluid. The light guide receives the first light energy and guides the first light energy in a first direction from a guide proximal end toward a guide distal end positioned within the balloon interior. The optical analyzer assembly optically analyzes a second light energy from the light guide that moves in a second direction that is opposite the first direction. The optical analyzer assembly includes a safety shutdown system to inhibit the first light energy from being received by the guide proximal end of the light guide.

A catheter system includes a catheter having an elongate shaft, a balloon and a light guide. The balloon expands from a collapsed configuration to a first expanded configuration. The light guide is disposed along the elongate shaft and is in optical communication with a light source and a balloon fluid. A first portion of the light guide extends into a recess defined by the elongate shaft. A protection structure is disposed within the recess and is in contact with the first portion of the light guide. The light source provides pulses of light to the balloon fluid, thereby initiating plasma formation and rapid bubble formation within the balloon, thereby imparting pressure waves upon a vascular lesion. The protection structure can provide structural protection from the pressure waves to the first portion of the light guide.

A medical instrument includes two jaw members, at least one of which creates conditions of frustrated total internal reflection at a tissue-contacting surface when tissue is grasped between the two jaw members. The first jaw member may include an optical element having a tissue-contacting surface. The medical instrument also includes a light source that provides a light beam for sealing tissue. The light source is positioned so that the light beam is totally internally reflected from an interface between the tissue-contacting surface and air when tissue is not grasped by the jaw members. When tissue is grasped by the jaw members, at least a portion of the light beam is transmitted through that portion of the tissue-contacting surface that is in contact with the tissue. The light source may be movably coupled to a jaw member to scan the light beam and/or to change the incident angle based on optical properties of the tissue.

There is provided herein a catheter for resecting an undesired tissue from a body of a subject, the catheter comprising a tip section in a shape of a cylinder or a cylinder's sector having a central longitudinal axis, the tip section comprising: a central longitudinal lumen; a first set of optical fibers configured to transmit laser radiation outside a distal extremity of the tip section, in a direction parallel to the central longitudinal axis; a second set of optical fibers configured to transmit laser radiation, transversely to the central longitudinal axis; wherein the first set of optical fibers and the second set of optical fibers are selectively operable to resect and/or ablate the undesired tissue.

Aspects of this disclosure pertain to a device with an elongated body having a distal end. The distal end may comprise a port that permits discharge of a laser energy towards a tissue from an optical fiber located in the distal end. An exterior surface of the distal end may include a cauterization portion that permits discharge of a cauterization energy towards the tissue. In some aspects, the device includes an insulative portion that attaches the distal end to the elongated body and limits energy transfer therebetween. Related systems and methods are also disclosed.

A catheter system for treating site within or adjacent to a vessel wall or a heart valve includes a light source, a first and second light guide, and an optical alignment system. The light source generates light energy. The first and second light guides receive the light energy from the light source and have respective guide proximal ends. A multiplexer directs the light energy toward the guide proximal ends of the first and second light guides. The optical alignment system determines an alignment of the light energy relative to at least one of the guide proximal ends and adjusts the positioning of the light energy relative to the at least one of the guide proximal ends based at least partially on the alignment of the light energy relative to the at least one of the guide proximal ends.

A catheter system (100) for treating a treatment site (106) within or adjacent to a vessel wall (108A) or a heart valve. In various embodiments, the catheter system (100) includes a balloon (104) and an inflation tube (219, 319). The balloon (104) has a balloon interior (146). The inflation tube (219, 319) is configured to guide a flow of an inflation fluid (132) into the balloon interior (146). The inflation tube (219, 319) has an inflation lumen (319A). The inflation tube (219, 319) is movable between (i) an first configuration (319F) wherein the inflation lumen (319A) has a first cross-sectional area, and (ii) a second configuration (319S) wherein the inflation lumen (319A) has a second cross-sectional area that is less than the first cross-sectional area. In various alternative embodiments, the inflation tube (219, 319) can be biased toward the second configuration (319S) or the first configuration (319F). The inflation tube (219, 319) can include a tube wall (319W) that varies in thickness

The present disclosure is directed towards a medical instrument. The medical instrument includes a housing and an end effector assembly operably connected to the housing. The end effector assembly includes first and second jaw members each having a tissue contacting surface, at least one of the first and second jaw members movable between a first, spaced-apart position and a second proximate position, wherein in the second position, the jaw members cooperate to define a cavity configured to receive tissue between the jaw members. The end effector also includes at least one light-emitting element coupled to at least one of the first and second jaw members, the at least one light-emitting element adapted to deliver light energy to tissue grasped between the first and second jaw members to treat the tissue.

Articles of manufacture, including terminations of or attachments to optical fibers are configured to substantially prevent axial emission and redirect radially most if not all light emanating from optical fibers. In that, a termination may include a fiber cap of a unitary construction of a tube and an optical element disposed to face a sealed end of the tube and dividing a hollow of the tube and having a conical surface, or an optical element dividing the hollow and complemented by a cone. An example of termination includes an optical fiber element having an up-tapered end with a maximum taper-diameter exceeding the core-diameter and ending at a conical element with an apex angle from about 70° to about 100°. Articles of manufacture additionally including mounting contraptions cooperating such terminations with cannulae to form an attachment to a laser system. Methods for transmitting light through such articles of manufacture.