A catheter system for pressure wave and inertial impulse generation for intravascular lesion disruption at a treatment site includes a catheter including an elongate shaft and balloon coupled to the elongate shaft. The catheter system includes a light guide disposed along the elongate shaft and at least partially within the balloon, where the light guide is in optical communication with a light source and a balloon fluid. The catheter can include a first focusing element located at a distal portion of the light guide and in optical communication with the light source. The first focusing element can direct light from within the light guide to a first location at a first distance away from the distal portion of the light guide to initiate plasma formation in the balloon fluid away from the distal portion and to cause rapid bubble formation, thereby imparting pressure waves at the treatment site.

Herein are disclosed protected optical fiber terminations for use in the treatment of renal and biliary calculi. The protected optical fiber termination including a ferrule affixed to the optical fiber that provides the termination of the optical fiber with protection from contact with saline and/or biological fluids. The optical fiber termination can include open or closed ferrules. The open ferrules providing a means for maintaining a bubble, e.g., a Moses bubble on the termination; the closed ferrules providing a calumniated focus on the renal or biliary calculi.

A device for illuminating a treatment site, such as a human eye comprises a) an applicator and a b) Illumination light source for generating illuminating light (BL), c) wherein the applicator comprises a hollow needle with a distal end and with a target at the distal end and with an opening at the distal end, d) wherein the applicator has an optical fiber guided in the hollow needle to the distal end with a free end oriented towards the target, e) wherein laser pulses (LP) can be transmitted via the light guide, which emerge from the light guide at the free end and strike the target and generate a plasma (P) in front of a target surface of the target, f) whereby the treatment site to be illuminated is located in the area at the opening and the plasma is intended for direct or indirect treatment at the treatment site.

A catheter system for treating stenosis in a body lumen includes a first energy source, a second energy source, and a catheter. The catheter includes an elongate member that is navigable through the body lumen, a first acoustic energy emitter connected to the first energy source and configured to emit acoustic energy when energy is received from the first energy source, and a second acoustic energy emitter connected to the second energy source and configured to emit acoustic energy when energy is received from the second energy source.

A catheter-implemented transducer device for intravascular thrombolysis, is described herein. Such a transducer device includes a catheter defining a longitudinal axis and having opposed proximal and distal ends. At least one ultrasonic transducer arrangement is disposed about the distal end. The ultrasonic transducer arrangement is oriented with acoustic waves propagating parallel or perpendicular to the longitudinal axis. Optionally, the ultrasonic transducer arrangement is configured as a multi-layer stacked structure of ultrasonic transducer elements. Optionally, the ultrasonic transducer arrangement is a laser ultrasonic transducer arrangement. Optionally, the ultrasonic transducer arrangement is configured to operate in a lateral mode.

A photoacoustic catheter adapted for placement within a blood vessel having a vessel wall includes an elongate shaft, a balloon and a photoacoustic transducer. The elongate shaft can extend from a proximal region to a distal region. The elongate shaft can include a light guide that is configured to be placed in optical communication with a light source. The balloon is coupled to the elongate shaft, and can be configured to expand from a collapsed configuration suitable for advancing the photoacoustic catheter through a patient's vasculature to a first expanded configuration suitable for anchoring the photoacoustic catheter in position relative to a treatment site. The photoacoustic transducer can be disposed on a surface of the balloon and in optical communication with the light guide. The photoacoustic transducer can include a light-absorbing material and a thermal expansion material.

A catheter system for treating a treatment site includes an energy source, a balloon, an energy guide, and a pressure sensor. The balloon is positionable substantially adjacent to the treatment site. The balloon has a balloon wall that defines a balloon interior that receives a balloon fluid. The energy source generates energy that is received by the energy guide so that the energy guide can guide the light energy into the balloon interior. The pressure sensor senses a balloon pressure of the balloon fluid. A method for disrupting calcification at the treatment site includes the steps of generating energy with an energy source, positioning a balloon substantially adjacent to the treatment site, the balloon having a balloon wall that defines a balloon interior, the balloon interior being configured to receive a balloon fluid, receiving energy from the energy source with an energy guide, guiding the energy from the energy source into the balloon interior with the energy guide; and sensing a balloon pressure of the balloon fluid with a pressure sensor.

A catheter system for treating a vascular lesion within or adjacent to a vessel wall within a body of a patient includes a single light source that generates light energy, a first light guide and a second light guide, and a multiplexer. The first light guide and the second light guide are each configured to selectively receive light energy from the light source. The multiplexer receives the light energy from the light source in the form of a source beam and selectively directs the light energy from the light source in the form of individual guide beams to each of the first light guide and the second light guide.

A medical device may include an elongated body having a distal elongated body portion and a central longitudinal axis. The medical device may include a balloon positioned along the distal elongated body portion. The balloon may be configured to receive a fluid to inflate the balloon such that an exterior balloon surface contacts a calcified lesion within a patient's vasculature. The medical device may include one or more pressure wave emitters positioned along the central longitudinal axis of the elongated body. The one or more pressure wave emitters may be configured to propagate at least one pressure wave through the fluid to fragment the calcified lesion. At least one pressure wave emitter may include an optical fiber configured to transmit laser energy into the balloon. The laser energy may be configured to create a cavitation bubble in the fluid.

A balloon catheter according to the present disclosure includes: an elongated member; and an inflatable member supported on an outer surface of the elongated member and inflatable outward in a radial direction of the elongated member, in which from an inner side to an outer side in the radial direction, a laser emission unit that can emit a laser beam outward in the radial direction, a transmission portion that can transmit the laser beam emitted from the laser emission unit in the radial direction, and a light absorption portion that can absorb the laser beam having passed through the transmission portion are provided, and the laser emission unit, the transmission portion, and the light absorption portion are provided only in the elongated member, only in the inflatable member, or in both the elongated member and the inflatable member in a divided manner.