Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.

Provided is a kit for treating tissue of a subject. The kit includes a tool for creating a wedge opening within a bone tissue, and an implant. In some examples, the kit also includes an introducer configured to deliver the implant into the wedge opening.

A rotator cuff balloon (10) is disclosed, the rotator cuff balloon (10) includes a limiting structure (100) and a protective structure (200) connected to the limiting structure (100). The limiting structure (100) defines a curvature along a coronal plane. The rotator cuff balloon (10) conforms to the physiological structure of the human shoulder joint limits itself in the subacromial space and can reduce a patient's foreign body sensation, dislocation, functional failure and other adverse events.

The invention relates to a fastening device for an implant that is elastically deformable by stress, the length of the device in the unstressed state being less than that of the device in the stressed state, and the diameter of the device in the unstressed state being greater than that of the device in the stressed state, and to a kit comprising it.

Provided herein are compositions and methods for treating bone fractures. In particular, provided herein are systems comprising carbon fiber sleeves and biocompatible polymers and the use of such systems in treating or preventing bone fractures.

An implant for therapeutically separating bones of a joint has two endplates each having an opening through the endplate, and at least one ramped surface on a side opposite a bone engaging side. A frame is slideably connected to the endplates to enable the endplates to move relative to each other at an angle with respect to the longitudinal axis of the implant, in sliding connection with the frame. An actuator screw is rotatably connected to the frame. A carriage forms an open area aligned with the openings in the endplates. The openings in the endplates pass through the carriage to form an unimpeded passage from bone to bone of the joint. The carriage has ramps which mate with the ramped surfaces of the endplates, wherein when the carriage is moved by rotation of the actuator screw, the endplates move closer or farther apart.

The present invention relates to implantable medical devices (dental and orthopedic) (osseointegrable implants) textured by the additive manufacturing process. Such implants are prepared in such a way as to comprise a larger surface area of contact between implant/adjacent tissues, porous microstructure with complex geometry with controlled and diversified pore size, which confers several technical advantages. In addition, the present invention relates to the process of preparing said implants and/or screws with an optimized structure for accelerating osseointegration. Finally, the present invention refers to the use of said implants as carriers of drugs or cells in order to treat the site, promote its healing, tissue regeneration or promote cell growth.

The present disclosure provides a bone-implantable device and methods of use. The bone-implantable device comprises a body having an exterior surface, wherein a portion of the exterior surface includes a cured osteostimulative material comprising MgO.

Devices and methods of correcting vertebral misalignment, including, e.g., spondylolisthesis, are disclosed. In one embodiment, a vertebral implant may include an assembly configured to be secured to a first vertebral body, wherein the assembly includes a frame made of a first material and at least one end plate made of a second material different than the first material; a reducing plate configured to be slidably received over the central portion, wherein the reducing plate is configured to be secured to a second vertebral body; and an actuator configured to move the reducing plate relative to the frame.

An intervertebral implant component of an intervertebral implant includes an outer surface for engaging an adjacent vertebra and an inner surface. A keel extends from the outer surface and is designed to be disposed in a slot provided in the adjacent vertebra. This keel extends in a plane which is non-perpendicular to the outer surface; and preferably there are two of the keels extending from the outer surface which are preferably offset laterally from one another. In another embodiment, an anterior shelf is provided at an anterior end of the outer surface, and this anterior shelf extends vertically away from the inner surface in order to help prevent bone growth from the adjacent vertebra towards the inner surface. Further in accordance with disclosed embodiments, various materials, shapes and forms of construction of the component and/or keel provide various benefits.